Creatine kinase ? Also how can you get these tests that you listed?

@@johnathanabrams8434 This list is from the video. Mr Younger lists them out and I've added them to the comments in case anyone is struggling with cog fog or other health issues/disabilities. You can ask your GP/healthcare provider to run these tests. Mr Younger talks about this in the video. I'm not sure what you're asking with 'Creatine kinase', but I'm not a Dr.

@@johnathanabrams8434you can find a lab near you by looking on the internet. If your doctor or healthcare provider won't order look for labs that don't require a doctor's order.

I have used a lab called Ulta Labs but they are regional and located in the USA. This lab draws the blood but mostly sends the sample to Quest Labs or Lab Corp -these are the two biggest labs in the U.S.

@@johnathanabrams8434 A test for Creatinine Kinase (CK) is used to detect and diagnose muscle damage. CK is an enzyme found in the heart, brain, and skeletal muscles. When muscle tissue is damaged, CK is released into the bloodstream. Elevated levels of CK can indicate: 1. Muscle Diseases: Such as muscular dystrophy, myositis, or rhabdomyolysis. 2. Heart Attack (Myocardial Infarction): CK-MB, a specific form of CK, is elevated in the blood after a heart attack. 3. Trauma or Injury: To muscles from accidents, intense exercise, or surgery. 4. Other Conditions: Such as chronic kidney disease or certain medications that can damage muscle tissue. The test helps in diagnosing the extent and location of muscle damage and monitoring treatment progress.

The CRP is specifically "High Sensitivity CRP" (hs-CRP). There are two different versions of the test and they are used for different purposes. There is what is called a "conventional CRP assay" and that is looking at non-specific inflammatory response. This might be used for purposes of differential diagnosis; examples include in differentiating between Crohn's Disease and ulcerative colitis. What Jared Younger mentioned in the video is the "High Sensitivity CRP" test and it is a very good marker for Coronary Artery Disease (CAD) and useful in detecting the presence of or exacerbation of inflammatory processes. Be aware that there are some things that can falsely suppress the test results of hs-CRP. This includes anti-inflammatory drugs like OTC drugs (NSAIDS, salicylates, methotrexate, etc). Likewise, the results can be falsely elevated by things like IUD. If you're looking for CAD markers, falsely elevated results can occur with having a high BMI, smoking (which causes inflammation!), diabetes (causes inflammation!), hypertension, low HDL, high triglycerides, etc. Because those things all contribute to inflammation -so having those will increase inflammation. Hope this information helps.

@@Sam-ci8bp I don’t know if it helped the other person, but it helped me!!! Thank you! I have a high risk of having a heart attack, and I think this is elevated on my blood. My doctor didn’t seem concerned, so I figured she knew why I have this. I’m only 97 lbs, and 4’ 9”, so I’m not a likely candidate for this. I’m taking a screenshot of your response! How do you know all this, if I may ask? I had terrible inflammation a few months ago and thought I was going to die! I finally took an antihistamine because I developed severe allergies, and my joint pain went away!

@@Tinyteacher1111 I'm doing a dual degree in nursing. I also have health issues so I am always looking and learning. I'm glad the info was useful!

@@Sam-ci8bpWell, I wish you well! 🙏 Thank you for the info. I have had health issues for 21 years and now I know way more than I want to about toxins!!! Good luck!

Thanks for saying! Yes I think we have to dig in more and figure out the importance of values in this grey zone, especially since most FM and ME/CFS individuals I test are in that exact spot. Those "mildly elevated" values are meaningful. - Jarred Younger

Which tests did you find to be most useful? Thank you!

I forgot to add the fibro diagnosed by a rheumatologist. It was the initial diagnosis in this journey. And I had reactive arthritis after the campylobacter infection.

​@@bcwbarbThanks for your story and sorry to learn you have these maladies!

I had a similar experience, but mine was a live Babesia Mycroti Lyme infection which is exactly like malaria. I also have about 7 other Lyme+ infections and resurfaced viruses. I feel like I’m dying, but I’m trying to live!

​@@Tinyteacher1111hear u w my ❤️.. am. Long COVID,, past mold exposure, long Lyme(PCP doesn't believe in that), , + now suspect I have fibro.. de dr Paul Anderson, Seattle, on line daily w chrnoc disease info❤️❤️❤️

Good luck to both of you on your healing journeys. Have either of you tried LDN? It has helped me a great deal. Not covered by insurance as it is off-label use and I get it through a naturopathic doctor via a compounding pharmacy. But, worth it if you can get it and afford it.

Thanks! - Jarred Younger

Thanks! As you have probably seen as well, the Vit D levels are low in over 75% of the FM and ME/CFS individuals we screen (with about 25% of those having severely depleted Vit D). Undoubtedly there are many people struggling with chronic pain and fatigue who just need to get their Vit D or B12 levels raised. - Jarred Younger

@@youngerlab yes, especially considering these come with no negative effects if you avoid over supplementation, which is hard to do in the first place, and you can always test your status. Low Vit D is surely an issue in autoimmunity in general. I have yet to meet a person who did not present with low vit D at diagnosis of autoimmunity, which includes myself.

I have a naturopath that said I had resurfaced shingles and other viruses because of Lyme disease. I had no idea that I had this!

Thank you!

Yes, both -- but I see the most consistent abnormal elevations in CRP. We will probably put out a CRP and ME/CFS paper later this year. I haven't run the calculations, but it is looking like average CRP is around 0.5mg/L for healthy individuals, and around 6.0mg/L for ME/CFS. I don't know if all the labs are finding the same thing, but the difference is very clear in the people we test. - Jarred Younger

Good question because for years my csf(cerebral spinal fluid) was tested and it was when my PSA became severe and it was showing there too. Headaches are serious and I think that most of the time they are not associated with an inflammatory disease when I personally have seen evidence showing that it is affected and I am also a patient, my comment was earlier and I am completely disabled.

Are you saying inflammation from foods is a different test? If so, what is the best test for food inflammation?

@@royrogers495 Where did you get that idea? I'm just saying that food is the most common cause of inflammation, especialy given the standard American diet, high in processed foods.

​@@royrogers495.. im. Long covid+ developed food sensitivities.. I avoid hi histamine foods.. use lod fodmap, trying to heal the gut.

I wanted to add that the current reference range for “normal” ferritin is very wide and doctors aren’t helpful. Low ferritin can cause many unpleasant symptoms

That is a great point about ferritin that I should have made in the video. Thanks for bringing it up. In some of the tests I mentioned, lower is always better. But ferritin and fibrinogen are exceptions where too low can be bad as well because they are involved in processes besides inflammation. Ferritin is critical for iron utilization and low ferritin is a problem for many people. As you noted, in individuals with significant inflammation, ferritin tests stop being useful screens for anemia. And there are some individuals who have inflammation-induced anemia. The related tests like transferrin and direct assessment of iron can help, but I do not think there is a clear marker of inflammatory anemia. The diagnoses need to be pieced together from many sources of info. - Jarred Younger

Hello! I may have phrased that statement awkwardly. I was trying to say that individuals with high ESR are more likely to respond well to LDN. It seems that LDN works particularly well in people who have evidence of sustained inflammation. - Jarred Younger

@@youngerlab Thank you for the clarification, that is really interesting

Great question! Thank you for asking as I was wondering this myself. I currently take LDN. Makes sense as at one point my ESR was pretty high. 👍

Same!!

Wow, that's a lot of $. Perhaps you can try a different lab as the costs can vary widely. Near me, Ulta Labs has a regular charge of $50 and a current sale price of $33.95. Plus they sometimes have sales for bundled testing.

“Brain fog” is a term used to describe a state of mental confusion or lack of mental clarity. It is not a medical condition itself but a symptom of other conditions. People experiencing brain fog may have trouble with memory, concentration, and processing information. Causes of Brain Fog: 1. Stress and Anxiety: Chronic stress and anxiety can impair cognitive function. 2. Lack of Sleep: Poor sleep quality or insufficient sleep can lead to cognitive issues. 3. Nutritional Deficiencies: Deficiencies in essential vitamins and minerals, such as vitamin B12, can affect brain function. 4. Medications: Some medications have side effects that include cognitive impairment. 5. Medical Conditions: Conditions like hypothyroidism, fibromyalgia, chronic fatigue syndrome, and autoimmune diseases can cause brain fog. 6. Hormonal Changes: Hormonal imbalances, such as those occurring during menopause or pregnancy, can affect cognitive clarity. 7. Mental Health Disorders: Depression and other mental health disorders can contribute to feelings of brain fog. 8. Infections: Some infections, including COVID-19, have been associated with cognitive symptoms like brain fog. 9. Dehydration: Not drinking enough water can affect cognitive function. Identifying and addressing the underlying cause is essential for managing and reducing brain fog.

One major cause is dysregulated blood sugar. Apparently another major cause is inflammation of the brain.

@@Sam-ci8bp I'm sorry but I strongly disagree, brain fog is a symptom caused by a medical issue. Whilst what you say might be technically true, it's potentially caused by all or any of the things you list what you're saying to me sounds a lot like how people with debilitating conditions are treated until quite recently when ME/CFS was dismissed as being all in the head. Brain fog is one the medical symptoms that can suggest you may have long COVID or ME/CFS. I find this comment extremely unhelpful.

@@Sam-ci8bp I didn't say I know there's a cure or that I disagree that it isn't caused by certain things you mentioned in your comment just that what you said didn't disqualify it from being a medical condition. I also think we should stop thinking in black and white ways about something that will obviously be very complex. Would you say a headache isn't a medical condition/symptom? There are also many causes as to why you might have a headache but that doesn't mean it's not a medical condition, and the treatment of it would depend on the cause. So having brain fog, a medical symptom, is a necessary piece of the jigsaw in diagnosing the treatment of a patient, or do you disagree with this?

This could be something to do with the vagus nerve. I have experienced this and it can be quite scary. I have had episodes where my heart felt like it had reversed itself (don't know how to explain it....felt like it was doing somersaults) . I listened with a stethoscope and my heart even missed beats for several seconds at a time. Freaking scary. At a later date I had severe chest pain and went to ER immediately and had an EKG and it showed normal sinus rhythm. 😅 Both times I was just sitting quietly at home reading. But I apparently have a problem with my vagus nerve. Among other things, I found inositol and glycine helpful. My naturopathic doctor told me to try them because I have autonomic dysfunction and sometimes my response to minor stimuli is grossly exaggerated. For example, taking my levothyroxine might feel like I'm taking a giant horse pill and it's tearing up my throat yet it's a teeny tiny pill. Or, turning my head can trigger acute projectile vomiting sometimes with complete loss of bladder control (I'm like ...do I throw up in the toilet and pee on the floor or pee in the toilet and throw up on the floor...??😢). I've been using those two together in powder form and they can be mixed into any beverage. Wow! They really help. And it's powder so I don't have the issues with the pills. I also sometimes lose my voice or my throat spasms. I could go on...everything that the vagus nerve is connected to, basically.

3 additional things: Berberine, pepcid, Lauriciden

I think I had an initial problem with LDN, too. I had to stop it for a while. When I resumed I started at 1.5 mg and took that for a good while before going up to 3mg. Now I have no problems with it.

GPCR antibodies Test. Available in Germany. Send it there

Ok

@@alias701 How does this differ from the standard ANA (anti-nuclear antibody) blood test? My neurologist says this blood test tells you nothing about what's happening in the CSF, i.e. the blood test could come back negative but it doersn't mean that autoantibodies don't exist in the CSF.

@@bradsalz4084this test is for autoantibodies against a type of cell surface receptor involved in many physiological processes.

I wish I could attach a pic. But in my fibromyalgia studies, those with ESRs around 15mm/hr have a 20% reduction of pain with LDN, ESRs around 30mm/hr have pain reduction of about 30% on LDN, and ESRs closer to 60mm/hr have a 50% reduction of pain with LDN. There are plenty of exceptions, but those are the general means. And I have run these analyses only in fibromyalgia participants. - Jarred Younger

@@youngerlab Very cooool

How did you find this out?

I'm glad you could watch it! - Jarred Younger

he needs to move out of the house asap. implement a strict ketogenic auto-immune paleo diet (or a lions diet if he wants to keep it as simple as possible). he MUST be 100% gluten and dairy free. add 2g of EPA/DHA per day, 1g of Krill Oil, curcumin, some PEA and Holy Basil. 3x1g Vit C, and a high quality B vitamin complex per day. Add Luteolin, Apigenin, Eutropoflavin as needed. The latter has a strong anti-depressant effect (similar to psilocybin). Add ProdromeGlia (plasmalogens) if possible (quite expensive, but worth it!)

Thank you. Where did you obtain your knowledge and where do you purchase the substances you mention?​@@awaken69

Dr Myhill in the UK would probably have a lot of advice on her website that might help you.

Is this sepsis, because no one tells me anything and I have a new doctor after mine retired unexpectedly. I contracted pseudonymous aeriginosa during a breast implant removal operation (where I actually stopped breathing and had to be revived), and no one would believe I had anything wrong with my excruciating chest pain until my incision festered 8 weeks later. I was put in cipro. I absolutely feel it did something to me because I developed leg pain that I had as a child after that infection. I also have other health problems from the implants, autoimmune diseases, infections, mold toxicity, Lyme disease, brain fog and now I’m in freeze response from CPTSD.

Maybe it’s polymyalgia rheumatica?

This guy is a f in bull s tter

Yes the same

You probably felt quite poorly then! 35mg/L is not unusual for a flu or similar viral infection. Bacterial infections can take it well over 100mg/L. When I see over 20mg/L in my lab, it is usually an acute infection of some sort. In those cases, I just give them a couple of weeks and we re-test. - Jarred Younger

Probably Mast cell activation syndrome (MCAS). IL-6 and TNF are two of over 1050 different types of mediators that Mast cells can produce and release, where a large part of them are inflammatory. There are also other immune cells that can release IL-6 and TNF. From BBC. Long Covid triggered our MCAS, but doctors didn't believe us From National Institutes of Health (NIH). Mast cell activation symptoms are prevalent in Long-COVID Mast cell activation syndrome and the link with long COVID Mast cell activation is associated with post‐acute COVID‐19 syndrome Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome Immunological dysfunction and mast cell activation syndrome in long COVID