18: How Stem Cells Work, Use in Brain Injury and the CCR5 Receptor l Stanley Carmichael MD, PhD

Рет қаралды 10,950

Күн бұрын

In this episode of the UCLA BrainSPORT Podcast, Adel discusses Stem Cells with the chair of the UCLA Department of Neurology and accomplished stem cell and brain injury research scientist, Dr. Stanley Carmichael. The two discuss what stem cells actually are, how they work and the evidence for their use in brain and spinal cord injury. They further discuss what utilizing stem cells to treat these injuries might look like in the future and current research directions. The pair then shift to discuss Dr. Carmichael's latest work, researching the blockade of the brain's CCR5 receptor. This has demonstrated great potential to enhance brain injury recovery, reverse the effects of dementia and even enhance healthy brain function.
For more information on the UCLA Steve Tisch BrainSPORT Program: ucla.in/3t6Q77b
All episodes are available at bit.ly/3I33gVL
Connect with us on social.
Instagram:
show: @_brainsport
host: @adel.neuro
Twitter:
show: @UCLABrainSPORT
host: @ahdelneuro
Have a question? Email us at BrainSportPodcast@mednet.ucla.edu
*This video is for informational purposes only and is not intended as a substitute or supplement for professional medical advice, consultation, or expertise. Please see a medical professional if you have any questions or concerns regarding any symptoms or injuries you have had.
#BrainSPORT #UCLA #UCLAHealth #UCLACommunity #StemCell #Neurology #BrainInjury #SpinalCordInjury #Dementia #BrainInjuryRecovery
00:00 - Intro
5:12 - What are Stem Cells?
13:52 - Exosomes
17:53 - Evidence for Stem Cell Use in Brain Injury
25:24 - How do Stem Cells Work?
30:53 - Enhancing Stem Cell Survivability after Implantation
32:42 - Stem Cells for Spinal Cord Injury
34:29 - Tracking Stem Cell function with Optogenetics
37:08 - Longest Survival Time of a Stem Cell in the Brain
37:54 - fMRI to track Stem Cell Integration
39:15 - Stem Cell Migration to Injury
42:12 - Stem Cells and Neuroplasticity
43:54 - What would Stem Cell Implantation look like in practice?
46:15 - Stem Cells with Mutations?
47:19 - Best Timing for Stem Cell Implantation
49:40 - Potential Adverse Effects of Stem Cell Implantation
53:12 - Challenges to Stem Cell Therapy
58:25 - Future Direction of Research in Stem Cell Therapy
1:01:16 - The CCR5 Brain Receptor
1:03:34 - Evolutionary Function of the CCR5 Receptor
1:05:31 - CCR5 blockade enhances brain injury recovery
1:13:50 - The current drug that already blocks CCR5
1:15:12 - Can CCR5 blockade reverse effects of dementia?
1:16:36 - Enhancing learning and memory by blocking CCR5
1:19:08 - Potential adverse effects of CCR5 blockade
1:22:02 - Final words on Regenerative Medicine

Пікірлер: 21

@chrisp1232 Жыл бұрын

WE NEED TO DEMAND MORE OF OUR TAX DOLLARSA GO TO THIS.

@dmd7472 Жыл бұрын

Grow up

@chrisp1232 Жыл бұрын

@@dmd7472 i am 55 years old running a plumbing heating company 38 years. i know more about life than anyone you will ever know. so, WISE UP.

@joemeschke Ай бұрын

I'm planning on going to Mexico for intrathecal administration of mesenchymal stem cells to treat an acquired brain injury (abscess, not stroke) and would love to know if it's truly a viable option to help heal faster.

@gladysgonzalez8664 2 ай бұрын

How can I get in contact with Dr, Carmichael?

@chrisp1232 Жыл бұрын

Lets discuss the real problem. Why is the funding not there? In My sons case So called Autism(brain injured) get practicly no funding... Yet we send the Ukrain 65 billion dollarsa????? We asrent that stupd.

@joemeschke Ай бұрын

Coming from someone with a brain injury it's truly infuriating to watch all our tax dollars get thrown at someone else's war! And the FDA won't approve this type of treatment vecause it would actually cure diseases!

@OGUNBUNMIMICHAEL-dn2eu 9 ай бұрын

l love Dr Pius Ozigbe! My daughter and I loved watching him and his sister in operation Ouch and his "Dr who gave up drugs" He seems like such a genuine, empathetic, no bullshit guy who genuinely cares and makes complex issues easy to understand for the lay person.

@peterb4927 Ай бұрын

are you still looking trial partizipans

@budhyantomuliadi9214 10 ай бұрын

Please, what is the name of the drug at 1.14 minute?

@westfield90 Жыл бұрын

Sadly we are so far away from any effective and reliable therapies. The hype and promises made a decade ago didn’t pan out and most of the funding and research dried up because our knowledge was so comically superficial and lacking. This is a much more complicated process than we ever imagined. We missed the creation of mutations and tumors because we do not understand the stem cells signaling. Not in our lifetimes will we understand this well enough to bring a ground breaking discovery to market.

@alexwaltensperger8329 Жыл бұрын

Yyyy

@benji1868 10 ай бұрын

What?!? Leronlimab is the gem of the CCR5 antagonist. It’s the FDA that’s slow walking this molecule!

@marydat6578 10 ай бұрын

@westfield90, i agree on the complexities and frustrations many feel about the progress-or perceived lack thereof-in stem cell research and therapies. However, I'd like to share a different perspective. While it's true that the field has its challenges, effective treatments might be closer than you think. My husband underwent stem cell treatment 10 months ago, (just 1 month after his injury). The improvements have been pretty dramatic, to say the least. The real issue, as you touched upon, isn't just the technology itself, but rather access to that technology and patients' rights to utilize it. We had to fly a great distance to get the treatment, which shouldn't have to be the case. But the fact that the treatment exists and showed remarkable results speaks to how far the field has actually come. tis a complicated process, but progress is being made, even if it doesn't always seem like it sometimes

@niwawang4394 9 ай бұрын

Thanks for sharing.

@ASH-su6nb 3 ай бұрын

@marydat6578 just because the treatment looks like it worked doesn't mean it actually was causal, the fact you traveled means you went to a place that doesn't actually have any science behind it

@chrisp1232 Жыл бұрын

mAKE AMERICA GREAT AGAIN, end lobby money, create term limits, NOW!

@chrisp1232 Жыл бұрын

1 in 50 children affected....not important enough? C,mon its obviouse.