2,3 BPG formation occurs only in erythrocytes, not in the exercising cells! The reason that the 2,3 BPG is higher at tissue level RBCs is that the enzyme responsible for breakdown of 2,3 BPG (phosphatase) is pH sensitive - less active at a lower pH!

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Rapaport-Luebering Pathway occurs in RBC as one of its mechanism to metabolize glucose since RBS has no organelles for that. Please read it on Rodak's Hematology 4th Edition.

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massive teaching but how do the erythrocytes get rid of the BPG ?

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So, what's happen after that for 3-phosphoglycerate? Is there any product for pyruvate or no?

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Excellent video but I just don't get it, why will a measurable( high anyway quantity) of 2,3 BPG leave the cell in the first place and not became pyruvate? And the curve shouldn't stop in the region of the lungs as the BPG only binds to deoxyhemoglobin?

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So, are you saying 2,3 DPG occupies a heme molecule not allowing O2 to bind thereby increasing the dissolved O2 concentration making it more available for tissue in need at lower pressures?

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hi,in the absence of bpg,isnt the curve rectangular hyprbola?

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AK, Most 2,3BPG is actually produced within the erythrocyte.

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Deoxyhaemaglobin binds to O2 or co2

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I have read today that the Blood Units have the disadvantage that they don’t have 2,3 DPG( or too few) . That’s why they aren’t good when they have to deliver oxygen. I don’t understand that . Because the tissues make 2,3 DPD when they are in Stress, that means that it shouldn’t be a problem . Or does it mean , that die Units too few DesoxyHb hat, that’s why 2,3DPG from ours tissues don’t help .???? Please help

Not a nurse or Dr, just a concerned mother. I have a 5 year old girl with high hemocrit, high platelets, high hemoglobin, slightly high calcium, slightly elevated potassium, and slightly elevated iron saturation. I've recorded all she drank and she is not dehydrated. Please help

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How would say this affects ETC? Are you increasing the final electron acceptor (O2) then because of this you require a higher metabolic rate of glycolysis and TCA?

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How can we decrease 2,3 BPG in RBC

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One question: how is it 2,3-BPG formed in the excising tissue? Doesn't it need BPG-mutase and isn't it only found in the red blood cells and placental cells? Or am I wrong?

And one more thing, why are some haemoglobin molecules deoxygenated? Aren't they all supposed to be loaded with oxygen once they get to tissues so they can release their oxygen to the tissues that need it?

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I believe RBC are the only cells that produce 2,3BPG. Exercising cells sounds like you are saying any cell can produce.

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