#ErythroblastosisFoetalis
#Epistasis
#BombayPenotype
#fscbiology
#irtisamsbiology
#Fsc class12
What is Erythroblastosis foetalis?
What is Epistasis?
What is Bombay Penotype ?
ERYTHROBLASTOSIS FETALIS
Erythroblastosis Fetalis
(Rh Incompatibility)
By Antonette T. Dulay, MD, Main Line Health System
Last full review/revision Oct 2020
CLICK HERE FOR PATIENT EDUCATION
Erythroblastosis fetalis is hemolytic anemia in the fetus (or neonate, as erythroblastosis neonatorum) caused by transplacental transmission of maternal antibodies to fetal red blood cells. The disorder usually results from incompatibility between maternal and fetal blood groups, often Rho(D) antigens. Diagnosis begins with prenatal maternal antigenic and antibody screening and may require paternal screening, serial measurement of maternal antibody titers, and fetal testing. Treatment may involve intrauterine fetal transfusion or neonatal exchange transfusion. Prevention is Rho(D) immune globulin injection for women who are Rh-negative.
Epistasis is a phenomenon in genetics in which the effect of a gene mutation is dependent on the presence or absence of mutations in one or more other genes, respectively termed modifier genes. In other words, the effect of the mutation is dependent on the genetic background in which it appears
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