I studied a lot Chemistry during high school and Biochemistry at med school, but still feel enlightened by Prof Imperiali's lecture. Thank you so much, and thanks MIT for publishing this for us.

Protein structure: spaghetti with lots of little bits that haven't been cooked. I'm not going to ever forget that. Thanks Prof Imperiali

My God! I've literally never seen anyone explaining better than this professor. I've searched a lot of videos that provide basic protein structure information and none of them could satisfy me until I came across this 51 mins long masterpiece. Thank you so much MIT ❤❤❤

Thank you for bringing back my enthusiasm and passion for learning. I am truly touched and eternally grateful for these lectures.

In a polypeptide many of the bonds show free rotation, however the amide(peptide bond) is unique upon the fact that there is restricted rotation in that bond, like spaghetti with little bits that haven't been cooked

Very interesting. My background is in solid state electronics so I am familiar with solid state atomic structures and valences etc. It struck me that this topic is what I would call liquid state life enabling structures. Solid state electronics is about electron flow in solid crystals whereas this topic is about self forming molecular structures in water where non-covalent bonding is critical to structure formation. A very good instructor.

the best explanation I have ever seen for "Structures of Amino Acids, Peptides, and Proteins"

I know the information for years but never felt how awesome it actually is.

Substance defines form; form defines function. Sounds very much like an architectural mantra.

Great lecture. I am listening to the whole series and relearning things I forgot 20+yrs after receiving a biochemistry degree. I do take exception with her lack of comprehension of the humor embedded in the cartoon. What makes it funny is the cartoonist is clearly (it is illustrated!) referring to folding a physical map, like the kind we had to buy prior to ubiquitous GPS. And, to me, it is also implied that the cartoonist is fully aware that ‘genomes’ don’t fold, and proteins do, thus making it funny on a few levels. Context and expectation is what separates a humor cartoonist from a textbook illustrator, professor.

This is thoroughly satisfying. She made it look so simple and interesting. I have much better understanding now. Thank you for publishing this.

I want such kind of educators in India 😓…..i really impressed by the teaching style ❤️

God bless these wonderful lecturers that make their explanations available ❤️

You are an amazing teacher and know your subject so well. Inspired teachers are hard to find.

Thank you for your time and effort in posting these videos... note that if you keep the bath for the amino acids in a light and airy vibe so to speak nonlocal communication can occur...

What a great teacher!!, I wish I had the opportunity to attend a class with such an incredible teacher when I was in collenge.

She is not just a excellent professor. She is a beautiful dancer, I believe :)

tomorrow is my aa exam and this makes me feel so enthusiastic :DD thank you for sharing

Wow she's so good at teaching 🤣🤣 almost reminds me of like a harry potter movie where theyre at Hogwarts.

Amine group is at the alpha position to the carboxyl

She is an amazing professor!

Waow this is what I call good teacher and presentation and visual and speed....yez yez!

धन्यवाद आपका ऐसे lacture देने के लिए। 🙏

Thank you Prof. Imperiali, great lecture! btw 30:32 that spells harvardharvardharvard LOL

When proteins are smaller and not able to adopt too much of a folded structure they are called peptides

Is a polymer protein strand, recreated as a viral cancer gene in G_nome RNA carboxylic ameno chain, is it possible to replace the viral strand, your body recreated from your Chromosome stick recount for autonomous Operation production, as a G_nome viral protein stand with a Organic Chemistry Chain Reaction Formula and recreate the original polymer protein syrand with peptide bonded ameno's carrying the original genetic sequence, and set in place during uptake recount.???

The most abundant type of amino acids are with hydrophobic side chains

Absolutely well done and definitely keep it up!!! 👍👍👍👍👍

Amazing lecture! I wonder if AI solutions would allow for the prediction of the folding of AA sequences.

20:49 Why does she say the primary sequence does not determine function except by determining shape? The function of triosephosphate isomerase, for example, depends on the exact locations of the charged amino acids that serve as temporary donors and acceptors of protons. Saying only "shape" matters implies that charges don't. But a different protein with the same shape but a different charged/uncharged amino acid sequence would not have the same function. I am not a biologist or a chemist, but I believe it's possible to have two different proteins with the same shape (e.g. alpha helix or beta sheet) but a different charged/uncharged amino acid sequence.

A-amino acid - amino acids that have been encoded in our proteins

great lecture, interesting and pretty straight foward

Amazing! Thank you, professor ❤

46:01 why are half of the protein types written in red and the other in blue?

What a great teacher, heartiest regards

What an amazing lecturer!

This is much better than Gene Brown's 7.05. PreMeds ruined biochemistry back then.

Amino Acids part starts at 9:49

Very good Profesor, thanks 💖

Great lecture thank you

Thank you

Thank you so much for this informative lecture

superb lecture

33:40 Are these illustrations correct? It looks like some of the carbon atoms have been drawn in the wrong order, in both the alpha helix and in the beta sheet. We should have nitrogen and then the alpha carbon connected to the side chain (not shown) and then the carbon atom double-bonded to oxygen in the hydroxyl group and then the nitrogen of the next amino acid. But the pictures show nitrogen and then the carbon atom double-bonded to oxygen in the hydroxyl group and then the alpha carbon and then the nitrogen of the next amino acid. Also, in the beta sheet, the first carboxyl group has a single bond, instead of a double bond. Finally, the lower strand in the beta sheet shows a nitrogen connected to an oxygen, instead of carbon. Whoever made these pictures must have been on ethanol.

Never thought biochemistry could be so funn

Can polymerization AA happen in primordial soup ?

Could someone please summarise all the bonds everywhere like in primary structure, secondary, etc etc.

hey im med student but i dont know where are the community surfing on internet (forums, websites etc.) please give me some advice about how can i follow the community.

Thank you.

Wouldn't it be cool if you could measure the amount of water molecules produced from a condensation reaction, and from that figure out how many peptide bonds and therefore exactly how many amino acids were in a protein? They've probably already done this but i will pretend i've invented it.

(On Sunday of January 29, 2023). Introductory Biology and the Structures of Amino Acids (Alpha Amino Acids because of the Human Emphasis), Peptides (Dipeptides and Polypeptides) and Proteins (Quaternary Structured Proteins Along the Lines Of Collagen, Hemoglobin, And A multitude of others), otherwise the Basics and Fundamentals Proteomics (More than Covalent and Non-Covalent Bonding). PhD Barbara Imperiali, Emperatrix Mea Gloriosa Est; Ego malo Fare Qui Vedere. Heil!

Thank you!

I have a question to make. I have no chemistry/biology background. I have been watching the first 3 lectures and I am kind of lost with the jargon and the chemistry notation. Is it worth continuing or should I go back and review something before I continue?

What text they use? When we read "read 3.2 from the text" what text do they mean? Thank you!

Amine peptide- not complete spaghetti, spaghetti with little bits that haven't been cooked

is tyrosine hydrophobic and polar?

Biochemistry made easy.

Which is the software they're using in MacBook to present

Is this college content? I'm a high school student, so it feels a little difficult.

is it university vast lecture ?

9:48 to skip to title content

YA SE VOLVIERON LOKOS ALV JAJAJAJAJAJJAJA

Ma'am good name?

Polymers of amino acids are heteropolymers, made up of a bunch of different monomers

15:00

She says hydrogen bond but I always hear hydrogen bomb

harvardharvardharvardharvard

Back when cis still meant something

The stiff gearshift contrastingly print because control unquestionably change unlike a stimulating sister. expensive, comfortable armchair

jajajajajjajajajajajajaaj no mamen penados xD