In this lesson on stereochemistry, Chad comprehensively covers how to assign R and S to chiral centers using the Cahn-Ingold-Prelog rules and works several R and S configuration practice problems throughout the lesson. He begins with a simpler example and shows how to assign R and S to a chiral center in 3 different scenarios:
1) When the lowest priority group has a dashed bond
2) When the lowest priority group has a wedged bond
3) When the lowest priority group has a bond in the plane
Chad then moves on to covering trickier examples showing how to assign priorities for R and S when the same atom is attached to the chiral center. He describes how you move down the chain organizing each attached atom by what additional atoms it is attached to until a point of difference is found. Chad covers a couple of trickier examples involving this and involving how to assign priorities in molecules having double or triple bonds. Finally, he concludes the lesson by showing how to name compounds having chiral centers.
If you want all my study guides, quizzes, and practice exams, check out my premium course at www.chadsprep.com/organic-che...
00:00 Lesson Introduction
01:00 Introduction to the Cahn-Ingold-Prelog Rules for Assigning R and S to Chiral Centers
04:46 Assigning R and S when the Lowest Priority Group has a Wedged Bond
06:15 Assigning R and S when the Lowest Priority Group has a Bond in the Plane
10:25 Breaking the Tie: More Complicated Example of Assigning R and S
13:33 Assigning R and S Configuration with Double Bonds or Triple Bonds
18:48 Naming Molecules with Chiral Centers
www.chadsprep.com/