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Paolo Tarantino, MD, Dana-Farber Cancer Institute, Boston, MA, provides an overview of 5-year results and correlative analysis of the ATEMPT (TBCRC033) trial (NCT01853748) investigating adjuvant trastuzumab emtansine (T-DM1) versus paclitaxel plus trastuzumab for stage I HER2-positive breast cancer. The co-primary endpoints were to compare the incidence of clinically relevant toxicities between the two arms and to evaluate disease-survival (DFS) in patients receiving T-DM1. The 5-year DFS for T-DM1 was 97.0%, the 5-year recurrence-free interval (RFI) was 98.6% and 5-year overall survival (OS) was 97.8%. Although the study was Although the study was not powered to evaluate the efficacy of paclitaxel plus trastuzumab, among the 114 patients receiving paclitaxel plus trastuzumab, a total of 9 DFS events were observed, including 2 distant events; the 5-year DFS with paclitaxel plus trastuzumab was 91.3% 5-year RFI was 93.3% and 5-year OS was 97.9%. These results confirmed exceptional long-term outcomes with adjuvant T-DM1 for patients with stage I HER2-positive breast cancer. This interview took place at the San Antonio Breast Cancer Symposium (SABCS) 2022 in San Antonio, TX.
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