I'm sure my wife will be mad I didn't clean up first, but instead of just tips and tricks, here's what my work from home area looks like, with context.
I've been working from home pretty full time for something like five years now, and at least 1/4 time for over 10 years.
I am sure, doing this all off the top of my head, I missed something or said something confusing so ask questions as you wish.