Acute Leukemia - ALL and AML - Hematology and Oncology Series

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Acute Leukemia - ALL and AML - Hematology and Oncology Series

Рет қаралды 363,989

Күн бұрын

Acute Leukemia - Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML) - Cancer (malignant neoplasm) of the bone marrow and the blood - Hematology and Oncology Series. Bone marrow biopsy (bone marrow aspiration) -Chemotherapy, Radiation therapy, Bone marrow transplant.
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Пікірлер: 257

@MedicosisPerfectionalis 2 жыл бұрын

📝 Download Notes: www.medicosisperfectionalis.com/

@user-rv9xw8sk1g Жыл бұрын

Thank u very much. I get 18from 20 in med exam of hematology🎉

@abinet060 7 ай бұрын

amazing

@abrahammatar1671 4 жыл бұрын

You are changing the history of medicine, dude!

@MedicosisPerfectionalis 4 жыл бұрын

Thank you so much 😊

@markahesabi3171 3 жыл бұрын

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@inessmasiye9877 2 жыл бұрын

❤️💙🤍💜

@heybruvv2733 Жыл бұрын

Is that really a compliment?

@abrahammatar1671 Жыл бұрын

@@heybruvv2733 Sure!

@cello9877 3 жыл бұрын

I'm on my third year of being a pre-med student and whenever I can't absorb the information on the books anymore, I just go to your channel. More like I like how you approach the lessons! Just wanna say thanks!

@AA-vh1vr Жыл бұрын

قناتك كنز أنا محظوظ لأني وجدتها ،بالاضافة إلى ذالك لقد درست عليك في مادة الانيميا وامتحنتها وقد صادفت سؤال لم يستطيع اغلب الطلاب حله الا انا حللته لأنك ذكرته في الشرح شكراً جزيلاً لك

@MedicosisPerfectionalis Жыл бұрын

😊😊🙏🙏🙏

@matsblindheim6039 Жыл бұрын

Love the dry humor and super casual attitude

@MedicosisPerfectionalis Жыл бұрын

Thank you 😊

@Mariabarlow3 2 жыл бұрын

Some people just have the gift of getting through and communicating well. You have that gift. Thankful for videos like these!!!

@MedicosisPerfectionalis 2 жыл бұрын

Thank you 🙏

@runescaeper78 5 жыл бұрын

I watched most of your hematology videos, awesome fun and simple way of explaining things that are over-complicated by books! Thank you !

@MedicosisPerfectionalis 5 жыл бұрын

Cool...I am happy to help 😊

@martinezbiz 3 жыл бұрын

My wife and I lost our just turned 2 year old son 7 months ago to Aml. He had MLL gene rearrangement or subtype KMT2A or 11q23. He had a translocation between chromosomes 6 and 11, t(6;11). He received cytarabine, daunorubicin, etoposide, gemtuzumab ozagamicin then mitoxNtrone and cytarabine. He relapsed after the second chemo which signified refractory Aml which had a poor prognosis. Decitabine with mylotarg was then used. He died shortly after from within 4 months of treatment. Some side effects he had were bloody nausea and diahrea. Horrible bloody mouth sores. He was in pain all over. His right eye was covered by a leukemia pool that ended up bleeding.He had a lot of liquid in his lungs which they thought was pnemonia. He ultimately died from a brain bleed within 24 hours caused we think by the chemo.

@AK-zw3yz Жыл бұрын

Oh! I am so happy for u. I am an elder sister. I have a younger sister. She has some weird symptoms. Idk what doest it mean. 1) light headed 2) tired & weakness 3) coughs and flu 4) nose bleed 1 time (gum bleeds) just a little bit 5) today she has a unbearable pain on her teeth,ear & arms. But I said my mom about it & she doesn’t care about it. She wanted to say I am much hypochondriac. Basically I am so much obsessed with my sister. Maybe I love her a lot

@benzaboyplayz7296 3 жыл бұрын

On my second relapse of ALL, now I finally understand what’s happening. Great video

@MedicosisPerfectionalis 3 жыл бұрын

Thank you! I wish you a speedy recovery!

@redactedpizza2278 3 жыл бұрын

I hope everything goes well this time around. Stay strong 💕

@hiimdominic3780 2 жыл бұрын

You got this. What hospital are you going to?

@leoniegray6404 2 жыл бұрын

My son has been diagnosed recently , my heart goes out to you . Horrible illness and aggressive treatments. Stay strong .

@nsudatta-roy8154 Жыл бұрын

Have you considered "intracellular" glutathione therapy? There is a whey protein that has a precursor that raises glutathione inside the cell. That glutathione is now able to promote "monoclonal expansion" of T-cells (cd4/cd8) which places cancer cells into "negative feedback inhibition." It works amazingly will in leukemias and many other cancers.

@HeshamAhmedEtBrigade 6 ай бұрын

Even after 5 years you are my teacher thank you

@MedicosisPerfectionalis 6 ай бұрын

Thank you!

@shahdismailalqatu9711 5 жыл бұрын

keep going sir :)) this is so helpful, and like I spent 20 hours trying to understand this yesterday but you made it so clear for me in less than 15 mins .. awesome content too .

@MedicosisPerfectionalis 5 жыл бұрын

So happy that I was able to help...How did you find my videos?

@merhaba961 3 жыл бұрын

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@AdianA-jv4ix 5 ай бұрын

It’s amazing how you explain this you make it easy to understand

@rajkanyapatil5097 4 ай бұрын

So simple to understand Your way of explaining things is great .. finally found the best u tuber for pathology lecture ..keep it up bro

@Nour-uo1tb 3 жыл бұрын

well, this is the first time i comment on a video on youtube, you're amazing! thank you so much, and keep going sir.

@MedicosisPerfectionalis 3 жыл бұрын

My pleasure 😇

@angelebeh3036 3 жыл бұрын

"Crazy, useless, immature cancer cells" 😂

@baslksa6 5 жыл бұрын

You are literally amazing thank you so much I'm studying my lab module right now !🙂

@MedicosisPerfectionalis 5 жыл бұрын

Excellent...Thanks a lot!

@samet3359 10 ай бұрын

that ALL drawing at testicles at 7:33 is perfect 😂

@yuiyui3331 11 ай бұрын

You know what is attractive, its your voice😁😁

@MedicosisPerfectionalis 11 ай бұрын

Thank you ☺️

@raveenakandera3699 Жыл бұрын

Very nice explanation ....

@MedicosisPerfectionalis Жыл бұрын

Thank you 🙏

@user-yl6cy1fp3k 6 ай бұрын

youre the best teacher ever!!!

@MedicosisPerfectionalis 6 ай бұрын

Thank you!

@MuWiStudio Жыл бұрын

I honestly like the way you make life easier

@MedicosisPerfectionalis Жыл бұрын

Thank you ☺️

@Ra-ko1yo 2 жыл бұрын

Thank you ,, your videos are so informative and cool .. this helped me in my study leave alot

@MedicosisPerfectionalis 2 жыл бұрын

My pleasure 😇

@LS-hb2ze 5 жыл бұрын

Hi You the best,you taught easily and what’s necessary.Thank you God bless you.👌🏻🙏

@MedicosisPerfectionalis 5 жыл бұрын

I am honored:)

@muhammadaarif9894 Жыл бұрын

Thanks a lot man this helped a lot for my FINALS!

@MedicosisPerfectionalis Жыл бұрын

Glad it helped!

@malakalotaifi1681 4 жыл бұрын

Thanks a lot for making my life easier!

@MedicosisPerfectionalis 4 жыл бұрын

My pleasure 😇

@ahmedrahman7019 6 жыл бұрын

you're the best keep going🔥🔥🔥🔥

@MedicosisPerfectionalis 6 жыл бұрын

Appreciate it, brother!

@gemmarium4337 3 жыл бұрын

I had a friend get diagnosed with AML in November 2010 and pass away from it in January 2011. It is so rapid and aggressive.

@maryjohns7968 2 жыл бұрын

Was it caught late?

@gemmarium4337 2 жыл бұрын

@@maryjohns7968 no she only began showing “mild” symptoms maybe 3 months(?) prior to diagnosis. At the time of diagnosis however her condition was bad. Very high relentless fever, very pale, weight loss, no energy, bruises everywhere… I’ve never seen a disease like this.

@umutk6339 3 жыл бұрын

I'M DRINKING LEMONADE

@MedicosisPerfectionalis 3 жыл бұрын

Enjoy 😉

@malazsaadkambal3988 3 жыл бұрын

Oh I can't explain how these videos are amazing thank u♥️🌸

@MedicosisPerfectionalis 3 жыл бұрын

Thank you 🙏

@ahmedaliisak1657 3 жыл бұрын

Thank you sir. my teacher ileen😂 watches your video's No more headaches. var caught😁

@MedicosisPerfectionalis 3 жыл бұрын

Thank you so much 😊

@muhanadmohamedabdi2273 3 жыл бұрын

Hahaahah i can't breathe 😁

@markahesabi3171 3 жыл бұрын

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@merhaba961 3 жыл бұрын

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@drpsyco6584 Жыл бұрын

I told everyone Be drunk and then study you will know medicine easily You are donerrrreerrrr♥️

@Ivedivealive 2 жыл бұрын

thank you for this thorough video! excellent visuals!

@MedicosisPerfectionalis 2 жыл бұрын

Thank you so much 😊

@rawyaretha9448 6 жыл бұрын

Thank you for make it so simple

@MedicosisPerfectionalis 6 жыл бұрын

My pleasure...Best of luck to you!

@markahesabi3171 3 жыл бұрын

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@PoojaSingh-id2ic Жыл бұрын

O my God dude! You are awesome!!!!!! 😃😍

@MedicosisPerfectionalis Жыл бұрын

Thank you 😊

@cerenfenerci2788 3 жыл бұрын

BEST explanation ever! Thank you so much!

@MedicosisPerfectionalis 3 жыл бұрын

My pleasure 😇

@markahesabi3171 3 жыл бұрын

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@merhaba961 3 жыл бұрын

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@kadyalthunayan4264 2 жыл бұрын

Thank you very much doctor

@MedicosisPerfectionalis 2 жыл бұрын

My pleasure 😇

@viper3636dr 4 жыл бұрын

Wow great overview. Very pleasant to watch too and informative. Thank you!!!

@MedicosisPerfectionalis 4 жыл бұрын

Amazing! Thank you so much 😊

@markahesabi3171 3 жыл бұрын

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@nooneoneno5387 5 жыл бұрын

excellent video.... great explanation..!!

@MedicosisPerfectionalis 5 жыл бұрын

Thanks a ton!

@diwasdiwas9790 5 жыл бұрын

you are the best. i cant believe u dont have many views yet.

@MedicosisPerfectionalis 5 жыл бұрын

Thanks a ton! You made my day! Please help me by sharing! Thanks in advance!

@diwasdiwas9790 5 жыл бұрын

@@MedicosisPerfectionalis sure

@MedicosisPerfectionalis 5 жыл бұрын

Thank you so much!

@sara-we9ut 4 жыл бұрын

Your absolutely the best I like ur videossss

@MedicosisPerfectionalis 4 жыл бұрын

Thank you so much 😊 Can you please help me by sharing?

@sara-we9ut 4 жыл бұрын

Medicosis Perfectionalis yeah sure I’ll, any other thing u want me help u in?

@MedicosisPerfectionalis 4 жыл бұрын

That’s more than enough...Thank you so much! Now, do you want any help from me?

@garwingchan3053 3 жыл бұрын

Thank you for your very good presentation.

@stephaniepresley6581 4 жыл бұрын

Hi I’m a retired HemOnc RN who has recently beenndiagnosed with LCH, aka: Langerhans Cell Histiocytosis Can you address a segment to this chameleon like disease? TIA

@bbaker904baker7 3 жыл бұрын

I wish I could better understand what is going on with me. They found out I had MDS for years that was masked by me having colitis for years. Some of the same in CBC tests are the same. Then suddenly after my colon was removed I came down with AML. All bone marrow biopsy showed I had MDS that progressed to AML. Lone of the mutations were bad. Chemo bought me all the way to cytogentic remission last Sept. Things went great until an adrenal test when I had to stop anything steroid for 5 full days. I started feeling sick, it didn't do away. In hospital the bone marrow showed my AML back with one catch. I have isolated 20q12. Percentage of bone marrow is 86%. Red cells, platelets, and B cells are low. Everything else is normal. Whites are slightly low but not dangerous. Doctors have never seen this. Nothing is documented. They gave me 6 to 8 weeks to live. Now that is up in the air when CBC just before giving me blood showed my platelets went from 30 to 70, Now the doctor doesn't know what will happen other than it will kill me. blast levels in marrow are 20%. Peripheral bone smear marrow smear show 5%. Blasts in blood 0.5%. Blasts in marrow are atypical with slight left shift. What is the world is this and how long do you think I will have to live.

@maryjohns7968 2 жыл бұрын

How are you

@yaiburanakul8505 Жыл бұрын

May you be healed of this cancer!

@Innerdiamond 3 жыл бұрын

Friend diagnosed with AML and he is almost 61. Was low in ferritin for a while. Anemic. Pretty healthy guy.. except I guess not.

@hral-aeen4206 4 жыл бұрын

Why does infection increase in leukemia (high WBC)? Due to dysfunction of WBC

@emmanmudassar2063 7 ай бұрын

Very helpfull👌

@MedicosisPerfectionalis 7 ай бұрын

Glad to hear that!

@pashteen8348 6 жыл бұрын

Simplified greatly

@MedicosisPerfectionalis 6 жыл бұрын

Thanks!

@afiqdanial2838 4 жыл бұрын

best explaination so far

@MedicosisPerfectionalis 4 жыл бұрын

Thank you so much 😊

@amiraelsayed84 3 жыл бұрын

What an amazing effort..👏👏

@MedicosisPerfectionalis 3 жыл бұрын

Thank you 🙏

@sunjokong6323 Жыл бұрын

You are awesome🥺. Thank you so much

@MedicosisPerfectionalis Жыл бұрын

My pleasure 😇

@mariaestrellitagonzales-me9798 3 жыл бұрын

THANK YOU 🙏 MORE POWER❣️GOOD LUCK 🍀

@ayass2598 5 жыл бұрын

can you please just give me the definition of monoclonal?? you are the best ..

@MedicosisPerfectionalis 5 жыл бұрын

Monoclonal: Originating from one entity (from one cell)...Think of it as plants originating from a common root.

@user-we8rb3rf4g 5 жыл бұрын

you are great thank u so much

@MedicosisPerfectionalis 5 жыл бұрын

You are very welcome! Thank you for watching!

@abishek485 4 жыл бұрын

Fantastic videos sir. Thank you for these. Really really helpful. ♥️♥️♥️♥️♥️♥️

@MedicosisPerfectionalis 4 жыл бұрын

Awesome 👏

@merhaba961 3 жыл бұрын

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@fatemaatia4385 5 жыл бұрын

@medicosis perfectionalis Thank you for this amazing illustration ;keep on 👌👏

@MedicosisPerfectionalis 5 жыл бұрын

and thank you for your kind words!

@ivanpuente5169 2 жыл бұрын

Thank you, sincerely.

@MedicosisPerfectionalis 2 жыл бұрын

My pleasure 😇

@simpenny8142 3 жыл бұрын

oh gosh!!! really like your presentation!! It's interesting & funny at some points! Thank you so much ^^ Btw, may I know which software/app did you use to write these notes??

@marcusgoh8491 5 жыл бұрын

I have a question, in acute leukemias, there are high number of blasts but does that translate to a high total white count? or leukopenia? and in chronic leukemia, I assume that it would be leucocytosis?

@abhikhalder7351 4 жыл бұрын

In acute leukemias there is neutropenia but WBC count is high due to blasts(as they enter blood stream).And in chronic leukemias there would be leukocytosis.

@mohamedelfarahaty8100 Жыл бұрын

brilliant

@MedicosisPerfectionalis Жыл бұрын

Thank you 😊

@akmaliafatimah6557 6 ай бұрын

thank youuu so much

@maryfawzi6308 5 жыл бұрын

That was so helpful

@MedicosisPerfectionalis 5 жыл бұрын

Thanks 😊

@mayzingasmr3145 2 жыл бұрын

Thank you very much for all amazing infos. Can you please make more lecture about immunohematology ( blood bank) please!

@amineaboutalib 3 жыл бұрын

one question tho, why doesn't it matter where wo do the biopsy? if the clonal cells haven't metastisized yet, they should be limited to one bone and only one bone no?

@dewiarianna 5 жыл бұрын

actually, how its become thrombocytopenia when ALL occurs? i thought it only influence lymphopoiesis lineage so it will never disrupt any platelet count.. please explain me doc :(

@MedicosisPerfectionalis 5 жыл бұрын

Hyper-production of WBC lineage will "crowd out" other cell lines such as platelets and RBCs leading to thrombocytopenia and anemia respectively.

@yashvisethia9056 Жыл бұрын

You are amazing

@MedicosisPerfectionalis Жыл бұрын

Thank you 😊

@97footballplayer 10 ай бұрын

This is a very good explanation. It is my assessment that your presentation covers the symptomology of the disease process and current medical practices to correct the symptoms. I am intrigued to understand the actual disease process occurring in/at the bone marrow level. Some questions I have are what hormone cascades/signaling hormones are involved in the negative feedback loop of the bone marrow. Is there pathology in the negative feedback loop? What is actually occurring in the marrow to produce these immature blast cells? We understand the presentation of the disease well but with is the pathology as it relates to the bone marrow? Heavy metal deposition causing ROS and altering mitochondrial function? Are “forever chemical” depositing in the marrow and cause risk for cellular disfunction. Perhaps a severe acute stress response or chronic stress due to interpersonal relationships, or work could leave someone particularly vulnerable to relapse? I have so many questions. Blood cancers don’t start a tumor growths/mass development. What is occurring in the marrow? Is there tumor development in the marrow of dysfunctional marrow cells? Does the diseased marrow spread to other marrow containing bones?

@shimom5724 5 жыл бұрын

Your videos are fantastic, thanks 💜

@MedicosisPerfectionalis 5 жыл бұрын

My pleasure 😇

@markahesabi3171 3 жыл бұрын

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@MD946 3 жыл бұрын

informative video. Loved it

@MedicosisPerfectionalis 3 жыл бұрын

Thank you so much 😊

@sobster123 3 жыл бұрын

there is squeaky weird noises in the background when I play this. strange.. nevertheless great vid as always!!! Thank you so much Medicosis i love you!

@MedicosisPerfectionalis 3 жыл бұрын

Thank you so much for your honest feedback!

@nour5459 3 жыл бұрын

Can you please explain the mechanism of Dic in acute leukemia :")

@MedicosisPerfectionalis 3 жыл бұрын

Please watch my video titled: “DIC”.

@ulfatgul868 3 жыл бұрын

Amazing explanation👌thank you so much

@MedicosisPerfectionalis 3 жыл бұрын

My pleasure 😇

@ahmadaljazeeri9287 3 жыл бұрын

Thank you man! I hope you enjoy your lemonade too 😂

@user-sm9tg4rc1n 3 жыл бұрын

Thank you so much for these videos!

@markahesabi3171 3 жыл бұрын

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@MrNaal5 2 жыл бұрын

This was really good

@MedicosisPerfectionalis 2 жыл бұрын

Thank you 😊

@hardik7942 5 жыл бұрын

If continuous cell division exposes the folate deficiency Anemia than there should B12 deficiency Anemia and Iron deficiency Anemia too right ?? Or is there any other mechanisms in it, plz explain if you know

@MedicosisPerfectionalis 5 жыл бұрын

Sorry, I didn’t understand the question...Can you phrase it in other words, please?

@hardik7942 5 жыл бұрын

@@MedicosisPerfectionalis At 8:17 you were explaining about Lab in Acute lukemia. Due to rapid cell turnover nd continuous cell division, sometimes there can be Folate deficiency causing Macrocytic Anemia......so my question is B12 or Iron deficiency Anemia can also occur right ? Bcuz those things are important in cell division or is there something else causing only folate deficiency Anemia.... hope you got my question 😅

@MedicosisPerfectionalis 5 жыл бұрын

Yes! You’re absolutely correct! B12 deficiency will be the last to appear because the liver store it for years.

@hardik7942 5 жыл бұрын

@@MedicosisPerfectionalis these things are easy to discuss on paper but in clinical diagnosis it must be hard to determine specific pathology 😐😓😕

@MedicosisPerfectionalis 5 жыл бұрын

Yup

@doctorv851 5 жыл бұрын

Based on physical examination that include age etc How can u differentiate AML & ALL

@MedicosisPerfectionalis 5 жыл бұрын

It's very difficult to differentiate between them based on the physical exam alone, we almost always need a bone marrow biopsy, peripheral smear, immunohistochemistry and flow cytometry. Based on age, ALL patients are usually (not always) younger. ALL is associated with Down syndrome, so you will see clinical features of Down's. AML-M3 subtypes has some specific characteristics such as DIC, AML-M5 has oral mucosa involvement.

@glisteningsky7251 2 жыл бұрын

Every time I study these topics I end with forgetting them all in the early morning hope this time is different

@glisteningsky7251 2 жыл бұрын

Thank you alot

@necipfazlay4059 Жыл бұрын

1:07 Hey! Don't neutrophiles stem from the same cells that make up monocytes, rather than other granulocytes?

@abdulraheemyounas6940 5 жыл бұрын

Hi! i am studying in (Medical Laboratory Technology 4years program) currently i am in 2nd year Hematology is include in my subjects, next month my annual exam will be start i watch the Leukemia videos there are a lot concepts are missing which i need i need your help

@rukiee.b.ovwigho5709 2 жыл бұрын

Medicosis perfectionalis. 👏👏👏❤️❤️❤️❤️❤️

@mahiehussein 4 жыл бұрын

Thanks!

@MedicosisPerfectionalis 4 жыл бұрын

You’re very welcome 😊

@areejzedan5034 3 жыл бұрын

you are the best,,, keep going

@MedicosisPerfectionalis 3 жыл бұрын

Thank you 🙏

@BobprestesBR 4 жыл бұрын

very good video

@MedicosisPerfectionalis 4 жыл бұрын

Thank you so much 😊 Can you please help me by sharing?

@BobprestesBR 4 жыл бұрын

@@MedicosisPerfectionalis i shared your videos to all my classmates !!

@way2happiness400 2 жыл бұрын

Hello! I'd like to thank you for this vedio . I want to ask , do you allow to take a screenshot of the vedio?! Thanks alot.

@norahalharbi7134 4 жыл бұрын

Excellent

@MedicosisPerfectionalis 4 жыл бұрын

Thanks 🙏

@karamaldeeb100 5 жыл бұрын

You are sooo cool 😎 Keep on

@MedicosisPerfectionalis 5 жыл бұрын

Thank you very much, I sure will!

@thokomasango2294 Жыл бұрын

FINALLY MEDICINE MAKES SENSE 👌🙌😅

@MedicosisPerfectionalis Жыл бұрын

Great 👍

@user-hf4sr5jr2d 4 жыл бұрын

awesomeeee explanation

@shackblack2903 3 жыл бұрын

can you recap the video content? I need it for the upcoming lesson

@Sevendandra 5 жыл бұрын

The auer rods in AML are in the cytoplasm right?

@MedicosisPerfectionalis 5 жыл бұрын

Yup 👍

@bhaveshgarg8142 3 жыл бұрын

when lukemia metastasize into the lymphnodes will it be called lymphoma?

@MedicosisPerfectionalis 3 жыл бұрын

Yes

@bibeksharma1767 3 жыл бұрын

can AML spread to lymph node and cause lymphadenopathy?

@basilsheikhahmad1499 2 жыл бұрын

hello, first i would like to say thankyou for your amazing videos. second i would like to ask regarding wbc count, i dont understand how it can be increased wbc or decreased

@MedicosisPerfectionalis 2 жыл бұрын

Cancer doesn't follow rules!