Dr. Barkley, I´m a huge fan of your work, your information has helped me in my clinical work and as an adhd patient. Thank you so much.

I really appreciate your thorough break down

Wow. I wish we had these options in the UK. I set an alarm to take my meds an hour before my ‘main’ alarm. So the delayed release formulation would be amazing for me. As I was suffering severe fatigue from 30 years untreated and the meds make getting up actually not torture!

Wow wow re the delayed overnight / extended release. That’s a game changer! We need that here in the UK

Thanks so much for this Dr. Barkley! I just got diagnosed at 29 a week ago and have been taking Adderall XR for 5 days now. I've been very curious about how the engineering of these pills work so I can try to find the ones I want to try. I'm an engineer myself so the tech is what counts :) (Well of course my response too lol)

I am 49 years old, and I’ve been using conserta for nearly 25 years. I’m curious about dosage. My first prescribing doctor pretty quickly landed me on a pretty high dose, 90 mg. This worked great for me. I have moved several times and changed health insurance and each time my new psychiatrist wanted to lower my dosage. I always resisted. I’ve never met anybody else on more than 54 mg. I’ve also never seen any research on the risks of taking higher doses. I eventually gave in and lowered my dose to 54 mg which is not as effective. I am getting by but it’s not as easy as it was. There is also heart disease in my family, so at nearly 50 years old I am being cautious, but I’m really not sure if it’s worth it. None of my psychiatrists or my cardiologist has been able to point to any actual science. Can you help me find good infromation?

Hello Dr Barkley, my 8 year old son recently started Biphentin and started presenting a vocal tic (coughing) within a week of starting. I do see some improvements in his ADHD symptoms with his inattention. Will these tics go away after a while or is there a risk that the tic may become permanent? No prior history of tics prior to medication.

Hello. Why do I have lower blood pressure (95/60 instead of 120/70) on methylphenidate- 10mg a day extended release? Should I do something about it? Thank you!

Does Russell Barkley have any clues to non prescription / natural based solutions that target the executive and related brain areas to solve this problem?

You said she should compete in speed eating. I kind of wish she would. It could be content.

Hello Dr.! Thank you for all these videos; your channel is incredibly insightful. I wanted to ask if you can address whether long-term stimulant use to treat ADHD can make the underlying issue worse? I was diagnosed as an adult and started treatment once I entered the professional world as I was able to cope my way through school and recently attempted to go off medication after switching from Adderall to Vyvanse. The latter gave me terrible side effects however after I attempted to go off it I found that I simply could not think at all; it felt impossible to do anything. I do not remember being this way prior and was wondering if my brain had become dependent on the medication or if this was just a matter of contrasting perspective. I've been having difficulty finding literature on the matter and would love to hear your thoughts.

Dr Russell, thanks for your great content! I'm from Brazil and I follow all your videos. Could you please help me with a big question? I am very afraid of taking Ritalin or Vyvense in the long term, because I am afraid of desensitizing my neurons or having some very strong side effect in the long term. I am 28 years old and I have been taking the drug for 1 year. I have moderate/severe ADHD and would need to be on medication for life. God bless you and thank you for sharing your content with us.

Hello Dr. Barkley! I really need your opinion on bupropion. I live in Greece and got diagnosed with adhd a few days ago at 22 years old and my psychiatrist prescribed me strattera at first, but it’s in short supply and I can’t find it anywhere. Then he recommended concerta or Ritalin but we have the same problem here in Greece with adhd meds in general and I’m really worried I won’t be able to get proper treatment due to that. Could you share some thought on bupropion? My psychiatrist told me it can help with adhd as well but it’s an antidepressant. Thank you so much in advance I really hope you read this comment because I’m really frustrated and I’d really value your input.

Just a question on pharmacokinetic differences between dexidrine and vyvanse: I see from studies that the curve for vyvanse is basically the same for an equivalent dose (1:3 ratio) except that it lags dexidrine by an hour. Is that right?

Methylphenidate and atomoxetine increase my resting BPM from 60 to 90-100 and I constantly feel my heart beating. I’m aiming to try vyvananse next. Hopefully it does not have this side effect.

Hi Dr, I’m a 35 year old woman who was diagnosed with ADHD last year. I started Adderall a few weeks ago, I was taking it for 2 weeks before my dr switched my medication. Unfortunately Vyvanse is out of stock so I went about a week with being medicated, which is fine, I’ve done it my entire life. But I have severe withdrawals. Mainly being sick, like feverish. Does Vyvanse have the same possible withdrawals? I’m terrified to start another medication. The withdrawal was HORRIBLE. I’d rather continue living with my issue than ever feel that way again.

I have a friend who’s 8/9 year old daughter had hallucinations after starting methylphenidate. They then tried her on a different brand of it (for some reason ) and the parents had to stop the medication when the hallucinations got bad again. The medication made huge improvements in her quality of life outside of that one severe side effect. The problem is that the hallucinations continued (though not as severely) several months after cessation of the medication. They now want to start her on straterra until the hallucinations stop completely. I can’t find any research on them extending beyond the cessation of methylphenidate and in the mean time this child is struggling with every aspect of life (quite a severe case). Can you offer any advice/research? Apologies for all the comments! I’ve been watching your videos all morning 😆

Hello Dr Barkley, your videos are very informative and I greatly appreciate your research and sharing it with us in an informative yet easily understandable format! I do, however, take one issue with a comment you made regarding simulant medication's loss of appetite being "not really a side effect" in adults and possibly even desirable. I am 30 and have been taking methylphenidate for almost a year since my diagnosis (as both Medikinet XR and Concerta at various doses), but my psychiatrist and I are actually planning on discussing switching to another drug. This is largely because the loss of appetite and nausea are affecting me negatively enough that I've come to dread taking the medication on days I know I'll need to eat lunch. I do not feel any active nausea when not around food, but for about 2-6 hours after taking the drug, the mere smell or thought of eating can leave me gagging, or I'm only able to eat a few small bites before I can physically eat no more. This understandably leaves me feeling hungry, light-headed and irritable during the middle of the day, especially since I've never been able to a large breakfast either, thus I basically have to wait for the stimulant effects to start wearing off in the late afternoon before I'm finally able to satiate my gnawing hunger. So between the hunger and inability to eat, and my light-to-moderate ADHD symptoms, I'd often rather deal with slightly greater inattentiveness and distraction than the unavoidable hunger pangs. All this is to say that I felt a bit hurt at your lighthearted insinuation that adults like me shouldn't mind the loss of appetite and rather be glad we can "lose some weight". I hope you will take this into consideration and perhaps in the future make less light over side effects that your own research numbers show can affect over 50% of stimulant medication users. Thank you.

Adult male age 73. Placed on every known (?) stimulant & non-stimulant w/o an impact! Historically with meds dosage has little to no effect. Reaching max dosage levels w/no impact, do doctors move on too quickly to the next medication?

#TomCruise is wrong.

What, if any medications are used(?) in neurodivergent brains

How can we counter act the weight loss, need the kid to gain weight.

Wow wow re the delayed overnight / extended release. That’s a game changer! We need that here in the UK