#IL4 #IL5 #IL13 #TSLP #IL33 #immunogenicity #immuneresponse #immune #Tcell #Bcell #antibodies #CD4 #CD8 #immunology #allergy #education #medicine #JANUS #jak1 #anaphylaxis #atopy #atopicdermatitis #asthma #asthmatreatment #abrilada #eosinophilicesophagitis #EoE #esoninophil #mastcell #basophil
#histamine #proteases
Educational video: do you know that sometimes our immune system can react as an allergic response? I present here an explanation of the immune response characteristic of allergic, and atopic diseases, the cytokines and intracellular signaling and why JAK1 inhibitors are good therapies for some of these diseases.
RECOMMENDED REFERENCES:
KZfaq Maria-Dolores Vazquez-Abad
hypersensitivity responses: • Types of Hypersensitiv...
Type I hypersensitivity • Immune response: Type ...
Antibody Response Th2 cells and B cells • Antibody Response Th2 ...
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in 5 min JAK1 in allergic and atopic responses • in 5 min: IL4 IL5 IL13...
IgE in less than 10 minutes • IgE in less than 10 mi...
Paul J Bryce, PhD Allergies FOCIS advanced course of Immunology, 2023
J. M. Igea. “The history of the idea of allergy” 2013, Allergy, Aug;68(8):966-73
Gell, P.G.H. and Coombs, R.R.A. (1963) Clinical Aspects of Immunology
Allergy Asthma Proc . 2019 Nov 1;40(6):470-473. doi: 10.2500/aap.2019.40.4274
Front. Immunol., 07 June 2018 Sec. T Cell Biology Volume 9 - 2018
Front. Physiol., Sec. Clinical and Translational Physiology Volume 10 - 2019 doi.org/10.3389/fphys.2019.01514
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanan S. Science 2002;298:1912-1934.
Protein Kinases: Human Protein Kinases Overview www.cellsignal.com/contents/s...
Changelian, P.S., Flanagan, M.E. and Borie, D.C., et al, Science, 2003, 302, 875 - 878.
Flanagan, M.E. and Changelian, P.S., et al., J. Med. Chem. 2010, 53, 8468-8484.
Flanagan, M.E., Brown, M.F., Subramanyam, C., and Munchhof, M.J., Ann. Rep. in Med. Chem., 2014, 49, 399-416
The Design of Covalent-Based Inhibitors Leonard Sung, in Annual Reports in Medicinal Chemistry, 2021 Clinical Immunology (Sixth Edition), 2023
Ferreira S, Guttman-Yassky E, Torres T. Selective JAK1 Inhibitors for the Treatment of Atopic Dermatitis: Focus on Upadacitinib and Abrocitinib. Am J Clin Dermatol. 2020 Dec;21(6):783-798. doi: 10.1007/s40257-020-00548-6. PMID: 32776305.
J Allergy Clin Immunol. 2013 Oct; 132(4): 789-788. doi: 10.1016/j.jaci.2013.07.046