Chronic Obstructive Pulmonary Disease (COPD) poses a significant global health challenge, yet little attention has been paid to epithelial alterations driving its progression. Researchers uncovered a novel mechanism involving DNA methylation affecting E-cadherin expression, disrupting epithelial integrity. By targeting epigenetic modifications with 5-aza-29-deoxycytidine (AZA), they restored tissue integrity in COPD-affected lungs.
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