Epigenetics

Рет қаралды 635,620

Күн бұрын

You know all about how DNA bases can code for an organism's traits, but did you know there's more influencing phenotype than just the bases? Explore epigenetics with the Amoeba Sisters by learning about a few types of epigenetic marks and some examples of them in action.
Contents:
00:00 Intro
2:14 Epigenetic Marks
4:13 Studies Involving Rodents & Epigenetics
5:51 Points about Inheritance and Factors Involving Inheritance
7:01 Why study Epigentics?
7:51 Epigentic Therapy
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REFERENCES:
Clark, Mary Ann, Matthew Douglas, and Jung Choi. “16.3 Eukaryotic Epigenetic Gene Regulation- Biology 2e | OpenStax.” Biology 2e. OpenStax, March 28, 2018. openstax.org/books/biology-2e...
Klug, William S, Michael R Cummings, Charlotte A Spencer, Michael Angelo Palladino, and Darrell Killian. Essentials of Genetics. Hoboken: Pearson, 2020.
Adams, J. (2008) Obesity, epigenetics, and gene regulation. Nature Education 1(1):128
www.nature.com/scitable/topic...
Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ. Epigenetic programming by maternal behavior. Nat Neurosci. 2004 Aug;7(8):847-54. doi: 10.1038/nn1276. Epub 2004 Jun 27. PMID: 15220929.
pubmed.ncbi.nlm.nih.gov/15220...
Robert A. Waterland, Randy L. Jirtle
Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation
Molecular and Cellular Biology Aug 2003, 23 (15) 5293-5300; DOI: 10.1128/MCB.23.15.5293-5300.2003
mcb.asm.org/content/23/15/5293
Dana C. Dolinoy, Dale Huang, Randy L. Jirtle
Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development
Proceedings of the National Academy of Sciences Aug 2007, 104 (32) 13056-13061; DOI: 10.1073/pnas.0703739104 www.pnas.org/content/104/32/1...
Simmons, D. (2008) Epigenetic influence and disease. Nature Education 1(1):6
www.nature.com/scitable/topic...
Zhang, T. Y., Labonté, B., Wen, X. L., Turecki, G., & Meaney, M. J. (2013). Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(1), 111-123. doi.org/10.1038/npp.2012.149
Oomen, M. E., & Dekker, J. (2017). Epigenetic characteristics of the mitotic chromosome in 1D and 3D. Critical reviews in biochemistry and molecular biology, 52(2), 185-204. doi.org/10.1080/10409238.2017...
www.cdc.gov/genomics/disease/...
www.sciencemag.org/news/1997/...
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FURTHER READING SUGGESTIONS:
This website is phenomenal for learning about epigenetics, and it was recommended in Pinky’s graduate course.
learn.genetics.utah.edu/conte...
More about histones?
www.nature.com/scitable/defin...
Why did we write the words “some exceptions” when mentioning that methyl groups generally prevent transcription? More info: www.ncbi.nlm.nih.gov/pmc/arti...
We mention these are only some examples of epigenetic marks. What others exist? Check out this further reading which mentions Micro-RNAs.
journals.physiology.org/doi/f...
What do we mean about epigenetic tags being “cleared?” Two great further readings:
learn.genetics.utah.edu/conte...
science.sciencemag.org/conten...
Epigenetic therapy with diseases?
www.ncbi.nlm.nih.gov/pmc/arti...
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MUSIC:
Intro music designed & performed by Jeremiah Cheshire.
End music listed free to use/no attribution required from KZfaq audio library.
TRANSLATIONS:
Turkish Subtitles by Kardelen Karaman
We want to thank our amazing community for the generosity of their time in continuing to create translated subtitles. You can submit translated subtitles here: www.amoebasisters.com/pinkys-...

Пікірлер: 253

@papuleabdulrahman8703 3 жыл бұрын

I just discovered this channel and wtf biology is actually interesting

@WilltheWise3406 3 жыл бұрын

The channel is so great, our whole class gets excited for biology because of how great their videos are.

@danielg1680 3 жыл бұрын

I get more information about biology through this video.... Stop talking about school

@MoltarTheGreat 2 жыл бұрын

Need a good teacher who is great at scientific presentation

@tiffanysotomi88 3 жыл бұрын

i just want to say that you guys have helped me so much in hs and you’re still helping me in university 🥰🥰

@greatsis5453 3 жыл бұрын

Can you advise me some Chanel at mathematics am in HS

@nielssandenbiermann8398 3 жыл бұрын

Khan academy is recommended! You should check out their website, it gives you tasks regarding the subject!

@hdgdjgsgfj1297 3 жыл бұрын

I recently discovered this channel while browsing the topic of biomolecules and I have to say that it is quite impressive! Thank you so much! Subscribed immediately after watching that video.

@Abbasjawad373 3 жыл бұрын

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@its_Roukiee 7 ай бұрын

I discovered it too while searching for biomolecules , I guess it's their lucky video😅😂

@warrenlehmkuhleii8472 3 жыл бұрын

“It doesn’t work on a punnet square.” High school biology has lied to me.

@greatsis5453 3 жыл бұрын

@@novasion327 no they are four states of matter you forgot the solution Are you at grade 10 ?

@dunebrowning9829 3 жыл бұрын

@@greatsis5453 There are more

@SkycryEmpathy 3 жыл бұрын

These are seriously some of the cutest videos I’ve ever seen! And I love the educational value of them! Thank you amoeba sisters keep up the excellent work! 💖

@meranda7215 3 жыл бұрын

This video is so interesting. Since middle school to undergrad I have never heard any teacher talk about this and I actually randomly stumbled across it while reviewing for a genetics exam so thanks! Biology is finally a not repetitive science to learn about

@robynwildwood5805 3 жыл бұрын

Hi! I absolutely love you girls sooooo much and I don’t think I’ve ever found a learning method quite as good as this. You make really complicated things just so easy to understand its incredible. I wish you covered more topics!! Please consider branching out or partnering up with other topics. Thank you ❤️❤️

@bshr5411 3 жыл бұрын

I don't really need to watch this video right now, I just came here to like the video and thank these two amazing sisters for their efforts ❤️❤️❤️❤️

@ushasharma4218 3 жыл бұрын

Me when I saw the title - Epicgenetics? Why of course genetics are always epic Me realising that title is 'Epigenetics' - Oh but genetics is still very epic

@loveyouzen 2 жыл бұрын

This made me laugh, have a good day!!!:)

@sunsunnn_ 3 жыл бұрын

My teachers always play your videos, and they help me so much for midterms 😭😂 thank u!

@zachhagen3145 3 жыл бұрын

I'm covering this in one of my year 1 college biology courses and this was very helpful and made it more interesting with the examples, thank you!! :)

@snow17048 3 жыл бұрын

During quarantine I watched all your videos because I was bored, and now they are the reason I am making it through 9th grade honors bio. Thank you!

@shriyayadalam1408 3 жыл бұрын

U guys have helped me so muchhhh for my exams making the content easier to study and fun to learn Sincere thanks!🥰

@yashrana610 3 жыл бұрын

Amoeba sisters cleared my all concepts that were fading while studying in my school :) thnx u sister

@cartoondoggy 3 жыл бұрын

Pinky! This is one of my favorite topics too. Have you read about the Dutch Hunger Winter? Or learned about how the fetus's size is affected by epigenetic markers from mom and dad? Fascinating stuff.

@heyitzsamurai 2 жыл бұрын

thank you!! often after i finish reading the chapter in my textbook i feel overwhelmed by the information. watching these videos helps sum up the big ideas and it really helps 😊

@yousefzedan9306 3 жыл бұрын

Finally my science teacher has seen the light.... She starting using Amoeba sisters today! Keep making awesome vids!

@justmelux3863 2 жыл бұрын

Hi! I just wanted to let you know that I'm studying this in my high school biology class, and I find it fascinating! All your video's are amazing

@kelvinlam9321 3 жыл бұрын

this clears every misconception that I've been seeing thru self-tutoring books, thank you so much!!

@elifoney306 3 жыл бұрын

This is actually so explaining and it helped me a lot to understand the logic of it. Thank you a lot.

@adiyabushra3647 3 жыл бұрын

You truly are the best! Keep going! 💞 I never met such a good KZfaq like you!

@DoraFora007 3 жыл бұрын

Im so impressed and in love with this sketches! And so easier to understand the topics. Thank you!

@rosee1314 3 жыл бұрын

This channel motivated me to learn more in Biology and made me realize how interesting biology is, very helpful

@kimssr1750 3 жыл бұрын

Oh my god. This is the best educational video channel I have ever seen! It is so addictively cute to watch!

@mariasanchezmenjivar8432 2 жыл бұрын

Thank you Amoeba Sisters!!! Hugs and kisses from Central America!

@Sara-gc9gu 3 жыл бұрын

this is the best video I've seen about epigenetics and its so helpful! thank you

@MushroomMan64 3 жыл бұрын

What a fantastic video! Keep up the good content, and I hope to learn more about the body with your videos!

@kasieeenda Жыл бұрын

THIS IS SUCH A GENIUS VIDEO, I love you so much for this, I was smiling the whole time❤

@gcbicca Жыл бұрын

I just discovered this channel and OMG it is so amazingly good! Thanks so much!

@anniemorning669 2 жыл бұрын

My college Tutor recommended your channel to me, I am forever grateful to ye and her

@osliec 3 жыл бұрын

Excellent videos!! I have used quite a few of them as teaching basis and will not hesitate to do it again! Just like many high-school curiculae, you are often focused on human physiology and related subjects, which is perfectly understandable. Sometimes you also venture into evolutionary biology, which is really great! But if you want to go a bit beyond, I would suggest that you dive into invertebrates (keep off the boring insects!)... -there are so many different subjects to look into while trying to step away from the (somewhat limiting) "human" perspektive. Lots of subjets to look into, morphology, reproduction, development, parasitism, feeding biology etc etc... -best wishes from Denmark

@ushnishsengupta6916 5 ай бұрын

Man so well illustrated !! Thanks for inspiring the biologist in all of us !!

@user-ei1wb1ph4l 5 ай бұрын

Thank you so much! Starting Epigenetics module and this gave me a head start before I dive deep!

@chikaokolo4929 8 ай бұрын

This is such an clear, simple explanation. Thank you 😊

@yousefzedan9306 3 жыл бұрын

this videos are STILL AWESOME!!! Keep up the great work Pinky and Petunia!! :D

@carloszelaya22 3 жыл бұрын

You guys are the reason why I love science

@zuzannagradek9895 3 жыл бұрын

Others:Get excited about wild parties ,travel and extreme sports. Me:gets excited beacuse the amoeba sisters posted a new video.

@Homosapien231 3 жыл бұрын

same lol

@snow17048 3 жыл бұрын

I am that person. I am also the person that when teachers put on bill nye in school I actually want to hear what he’s saying.

@lovekissy000 3 жыл бұрын

amoeba sisters really coming in clutch to save my grades lol #failingscience

@justinminor7382 3 жыл бұрын

I love yah i hope yah keep coming im a jr in college after this semester when I finish genetics and ecology i need yah for cell biology and capstone in the fall. Lets keep them videos up sisters love yah intelligence its a blessing🙏🏾

@kylemesa3959 2 жыл бұрын

Thank you so much for including references!

@nadaesawy7810 8 ай бұрын

This is fascinitaaaating ... I never liked or enjoyed a topic as much as I enjoyed this one... thanks a lot

@panosr2135 3 жыл бұрын

I don't know how you do it but you always upload the topics that i need for school. I go to a biotechnological high school and we dive much deeper in detail. Your videos are great tho to revise the topics and kept simple at the same time so if one didn't have time to revise the stuff with all the biochemical mechanisms he can still get an idea of what is happening. Thus, not left clueless in class :) Love you both ❤

@shannonstokes5891 2 жыл бұрын

this channel is getting me through my foundations of biology class

@Homosapien231 3 жыл бұрын

I just love your voice pinky, it is so clam and it is just funny and cute when your voice change because you are excited and interested about something. i honestly don't care about epigenetics much, i don't even study it right now, just came to drop a like and say 'Thank you so much' you deserve a million subscribers and more! keep up the good work!!

@AlvinCwk 3 жыл бұрын

are you reading my minds? I have a molecular biology final tmr and you just uploaded this

@feyza5763 3 жыл бұрын

Great timing^^

@cgmehta8264 3 жыл бұрын

It's funny because I'm in 10th grade rn doing AP Biology. My teacher showed us about epigenetics and it was SUPER cool!!! I agree with your interest in this topic!!

@simonmilk7975 3 ай бұрын

Absolutely well done.

@kevindinoneurociencia 2 жыл бұрын

I’m gonna present this in my embryology class in med school. Thak you amoeba sisters. THANK YOU!

@frroossst4267 2 жыл бұрын

Learnt about this in my intro to psych class and boy was I blown away

@JateBekker Ай бұрын

Your videos are so funny and enjoyable. Thank you for making them

@katieyu9374 3 жыл бұрын

I’ve gotten interested in epigenetics this year so I’m super excited for this video, thanks Amoeba Sisters!! ♥️🔬

@jeniferclark2154 Жыл бұрын

Great video, explaining nicely a really important topic!

@phatnigerianchic Жыл бұрын

Watched one video and I'm a subscriber. You are amazing. Thank you for making science enjoyable!!!

@Frrzrm 3 ай бұрын

One of the best!!

@boombot7716 2 жыл бұрын

i just want to say that you guys have helped me so much in hs and you're still helping me in university🥰🥰

@Jamillakitchen Жыл бұрын

😊

@jessicarobinson1608 2 жыл бұрын

Ameobas thank u so much for your effort and simplification of such advanced topics)))))

@brittanyjacobson5199 3 жыл бұрын

This is a very important topic, thanks so much.

@globalloving9023 3 жыл бұрын

Cool video. I love your biology. Thank you pinky for your teaching and thank you pitunia for your amazing images

@zahrajaffer2929 3 жыл бұрын

Saving every IB Bio HL students grade! Thank you!

@pikacoder5782 3 жыл бұрын

Thanks you have generated my interest in biology

@sunroses8357 3 жыл бұрын

Dear, amoeba sister. I hope you read my comments. I really love ur videos. You guys help me a lot in foundation studies. I hope u guys continue making videos like this and I really hope you can make video for degree level also. Keep doing videos, i am looking for it:) Thank you.

@nihaal7750 3 жыл бұрын

OOOHHHHHHH THIS IS ONE OF MY FAVOURITE TOPICS!!!!!!! THXXXXXXXX

@eliz4994 3 жыл бұрын

hello! im learning the nervous system now, i was wondering if you could make a video about that? your videos always help me understand better!

@davidvine5846 7 ай бұрын

Excellent presentation..... a little too fast but excellent. When I was a pre dental student the the University of South Florida ( 1965-1969 ) we had an excellent biology teacher ( Dr. Jerome Krivanick ). Through his lectures I acquired a lifelong interest in biology. Epigenetics was in it's primitive state at this time but just when you think you know it all things change and our minds expand. From the author of the book " Understanding First Class Dental Care" ( Amazon ) and the founder of the David Hamilton Projesct.

@yamu7211 3 жыл бұрын

goshhh..... you guys really made my day always tho. your content made it more easy,fun and cool! you made my 3rd fav subject turn into "the 1st fav subject" love your vids so much! -jhaz

@samgee5169 3 жыл бұрын

Thank you amoeba sisters !!

@andreciagl 6 ай бұрын

This is so cool ‼️

@khrisduarte 2 жыл бұрын

You guys are awesome!!!!! Thank you!

@specterme 3 жыл бұрын

How did you know i needed this😍 Tysm btw❤

@stephaniemomma Жыл бұрын

I’m here b/c the prf recommended viewing this vid in BIO 350 today, human genetics. I noticed a glib on your about me, thought I would share that these vids are definitely being used at the college level. BMB 300 had one of your vids at the beginning of the semester too.

@thefox1703 Жыл бұрын

Thank you for this outstanding video, it's very informative.

@alexandrashields2600 2 жыл бұрын

THANK YOU!!! So helpful.

@westfield90 10 ай бұрын

Stunning how smart people in history figure this out even without being able to see any of it. Stunning how some people are so intelligent to make such discoveries.

@ricardasist 3 жыл бұрын

Amazing video!

@prashanshanisandamini5941 Жыл бұрын

Thank u amoeba sisters❤keep going this kind of valuble things♾

@nahalymtl9445 2 жыл бұрын

wonderful. thanks a lot.

@YohGS 3 жыл бұрын

Great video!!

@lovekissy000 3 жыл бұрын

Omg love your videos!! Better than my whole bio teacher lol

@nisthapaudyal3738 3 жыл бұрын

Stop!! Hey C!! I love the Amoeba Sisters sooo much!

@Hirndisco 3 жыл бұрын

You had me at the "don't be suspicious" part

@cat5220 3 жыл бұрын

I love this channel 💕

@ather1717 3 жыл бұрын

Our teacher introduced you two to us and dude I had to instantly sub :D

@lameesbk70 Жыл бұрын

Thank you so much 🥰🥰

@backyyeee7647 2 жыл бұрын

you said u wishes you had learnt about this in highschool well im glad to tell you that im in year 11 and we are learning about this now!♡

@backstreetfan2887 3 жыл бұрын

Very nice, thank you.

@raheeqyamany3962 Ай бұрын

I really like your way !❤️

@lexi-op5vk 2 жыл бұрын

If this can make you happy here in Italy we study this in high school! I'm using your videos to help me study (since I suck in science)

@shijubincy 3 жыл бұрын

Hi Amoeba Sisters!!! I just got to say this is the most AMZINGEST CHANNEL EVER!!!!! Thank you so much! I sometimes draw your Amoeba pics! (You also made drawing a whole lot easier!) Keep up ur good work!! =) BTW: My daughter is saying this. =)