Anti-aging miracle molecule and the TRUTH about NMN supplements | Dr. Nichola Conlon

Anti-aging miracle molecule and the TRUTH about NMN supplements | Dr. Nichola Conlon | Ep 15

Рет қаралды 22,275

Күн бұрын

NAD may be a true "miracle molecule" in promoting health and longevity. NAD is a molecule that is critical to your body's cellular health. As you age, the levels of NAD decline, contributing to many age-related health problems, including decreased energy, impaired memory, skin aging, and disease risk. Recent research shows that boosting NAD levels has remarkable anti-aging benefits. NAD supplements are popular, but many people use them wrong.
In today's episode, my guest is Dr. Nichola Conlon, a microbiologist, the CEO of Nuchino, and a popular speaker. We discuss the science behind the miracle molecule NAD. We cover how it reverses aging, does NMN (Nicotinamide mononucleotide) and NR (Nicotinamide Riboside) supplements work, how to avoid risks, NAD testing, sirtuins, DNA repair, and how to boost NAD the safe way.
Dr. Conlon is a popular speaker who spreads information about practical, science-backed solutions for healthy aging.
NAD = Nicotinamide adenine dinucleotide
NMN = Nicotinamide mononucleotide
NR = Nicotinamide Riboside
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Dr. Nichola Conlon:
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Пікірлер: 149

@artten5002 Жыл бұрын

Loved this interview! Finally information I didn't know already

@iaminkaland Жыл бұрын

Glad to hear it resonated

@iaminkaland Жыл бұрын

Timestamps: 01:40 Research breakthroughs in anti-aging: reserves aging 03:50 What does anti-aging (reversing aging) mean? 06:55 At what age can we reverse aging? 08:50 What is NAD (Nicotinamide adenine dinucleotide) and why it is important for your health 12:40 Is NAD involved in all aging processes 14:15 When NAD start declining? 15:18 What declined NAD, and what habits help maintain NAD? 17:25 Symptoms of low NAD 19:03 Measuring NAD 20:30 What increases NAD 23:25 NMN supplements, NR supplements and other NAD precursors 24:50 How NMN can accelerate aging 28:15 Methyl donors 28:40 Inflammation, CD38 and NAD 29:35 How to inhibit CD38 30:00 Nuchido products 32:50 At what age should you start taking NAD-boosting supplements 34:40 NAD, Perimenopause, and menopause 35:45 A piece of advice 37:55 Links

@StraitjacketFitness Жыл бұрын

Just another comment and a Like for the algo. Stay shredded brahs (and brahettes), we're all gonna make it. ......... Peace. ..................... 0:00

@manuelsanchez9236 Жыл бұрын

Hi great information I'm 52 year old male I have Addisons disease I started taking NMN and TMG I started to feel much better and more energy

@iaminkaland Жыл бұрын

Thanks for sharing the experience!

@coralinenorman5149 Жыл бұрын

That's magnificent! :) What doses are you taking, please? All best wishes ^_^

@manuelsanchez9236 Жыл бұрын

I take 1000 mg of NMN and 1000 mg of TMG per day

@coralinenorman5149 Жыл бұрын

@@manuelsanchez9236 ~ Thanks so much for the info :) How long have you been taking these? Cheers ^_^

@manuelsanchez9236 Жыл бұрын

I only been taking it for 2 months so far but I'm planning to take more supplements from DONOTAGE brand.

@All-Father-Odin-967 Жыл бұрын

All Father, All Mother, thank you for making women. Especially, super smart, brilliant and articulate ones. Good work ladies.

@iaminkaland Жыл бұрын

Glad you found the episode useful

@ctguitarguy8510 Жыл бұрын

You can take apigenin in liposomal form as well to regulate CD38 levels, and help boost NAD+ levels in the body

@xanpena2858 Жыл бұрын

Recommendations on where to buy?

@peterz53 Жыл бұрын

I have been taking Time+ based on the science that Nichola laid out, but have been very disappointed that after multiple attempts I could not get an answer about their recently posted (at the Nuchido site) clinical data. They post crossover data to show the increase over placebo and baseline. About 17 ng/ml increase in cellular NAD+. Looks like a clear increase. The issue was that I could not get an answer about the baseline cellular concentration of NAD+. Showing an increase, they used units of ng/ml instead of umol, without indicating the percent increase or showing the starting point is of little value. Therefore, although I think this approach, support of the salvage pathway, makes more sense that taking NR or NMN, I will not reorder Time+ until clear data is presented. They have been talking about clinical data forthcoming for years, and it's still not adequately published. Mean time, I will be taking EGCG, quercetin, apigenin, etc for salvage pathway support from other sources.

@coralinenorman5149 Жыл бұрын

Hi Peter, Thank you very much for sharing this info. Have you noticed any health improvement from taking Time+? All best wishes ^_^

@peterz53 Жыл бұрын

@@coralinenorman5149 I can't say that I have. I do other things and there are no clear metrics for assessing changes. Like many other compounds which have been shown to have effects (mostly in animal or cell cultures) I am assuming that the effects will occur over the long term, and it may not be possible to sort out whether it is doing anything. We need a good reliable inexpensive test for NAD+ as well as other markers (mTORC1 expression). There are a couple of studies which indicate NAD+ can be preserved by consistent exercise over time and indications that maintaining low insulin helps to. But exercise and low insulin have a broad range of positive effects. Nichola has also said that exercise and fasting will raise NAD+.

@coralinenorman5149 Жыл бұрын

@@peterz53 ~ Thanks so much for your detailed reply :) The info you have shared is very helpful ^_^

@merlindxb4333 Жыл бұрын

The big reason for ageing is the decline in Nitric Oxide after the age of 30 its all downhill heading to Alzheimer's, cardiovascular, pulmonary cancer, organ failures, NMN is easy because it's a drug precursor, as is L-carnitine L-Arginine but iNO is the best of all, all requiring exercise.

@iaminkaland Жыл бұрын

Yes good point. Exercise is good for everything

@gangstagangsta9081 Жыл бұрын

One of the most informative videos on NMN

@iaminkaland Жыл бұрын

Glad it helped!

@unclewerner Жыл бұрын

Thanks, that was very informative. I was looking for quite some time to extent my herb garden with parsley. My grandma always had these in her garden and now I know why she outlived them all. Very interesting to learn about the CD38 connection.

@iaminkaland Жыл бұрын

Wonderful!

@mikehunter4301 Жыл бұрын

Really good information well articulated. I appreciate all that you do!

@iaminkaland Жыл бұрын

Thank you glad you enjoyed

@nikolagolub9668 6 ай бұрын

Obadvije ste lijepe i hvala na ovako lijepom i sadržajnom uratku. Ako mogu komentirati, drugi put se dogovorite oko postavljanja kamere na istu udaljenost i da stolice po mogućnosti budu iste visine, tako da snimak bude ugodniji. Pretplaćen.

@yoheurtel Жыл бұрын

Incredibly valuable informations we've got here! Thank you so much

@iaminkaland Жыл бұрын

Glad that you found it helpful!

@normacastillo7895 Жыл бұрын

Don’t be so easily misled by her unsubstantiated claims.

@christinablakeman556 Жыл бұрын

35:45 great advice. Makes so much sense. Thank you. Love this channel.

@iaminkaland Жыл бұрын

I think so too! and thank you - glad to hear it resonates. Thanks for being around.

@atiq191 4 ай бұрын

I took NMN for few months. Now stopped. A huge thanks to Dr Nichola for bringing up the scientific truth and educating us on the hype around NMN supplements.

@iaminkaland 3 ай бұрын

Thank you Dr Conlon indeed. It's great to have people so passionate and honest about new supplements on the market- and clearly explaining them to us. Thanks for the comment!

@neobellator Жыл бұрын

Excellent podcast! Learned a lot

@iaminkaland Жыл бұрын

Glad to hear that

@mhkm8 Жыл бұрын

Well done!! This was a very well designed interview to bring out so many cutting edge points on wellness and health span that Dr Conlon answered in concise, easy to understand language. Thank you both. Are you by chance already aware of direct gene activation of NAD?

@iaminkaland Жыл бұрын

Thank you. Glad to hear it resonated. Can you elaborate the question?

@mhkm8 Жыл бұрын

I’m a retired DC consulting with a small US based NASDAQ traded biotech company that has patented plant based products proven to activate the Nrf2, Nrf1 and NAD pathways you’ve discussed here. 28 peer reviews to date on the first. These directly affect oxidative stress, mitochondrial dysfunction and sirtuin production. I don’t want to come across as advertising in your comments but, given your interest and dedication, you should know about these ahead of the marketing curve at least for your own sake. If you’d like to discuss more just advise on how I might contact you off comments and I’ll reach out. Thank you again for your work in raising science-based wellness approach awareness.

@annemuller4499 Жыл бұрын

Crucial informtion for all NMN takers! 🤗 Thank you so much! That explaines why NMN works on some people like magic and on others not a bit. I do take TMG and Apigenin and Quercitin, but I still have no effects 🤔(sure I don't eat fast carboydrates etc.)

@iaminkaland Жыл бұрын

Great to hear you found it helpful! Yes it definitely makes it more nuanced :) Perhaps your cellular age is less but you won't feel it. have you measured your NAD levels? Do not Age have an NAD test. I can provide a code.

@luckssj Жыл бұрын

My age went from 71 to 65. My eyes are 38

@roslechte Жыл бұрын

Your eye sight improved ?👀 Can you notice? That is amazing if that's the case! How long have you been taking this? What exactly do you take, please?

@damiongh Жыл бұрын

It’s crazy, my right eye was rubbish, only been taking NMN for about a week and yesterday I noticed I can read text again. Don’t know if there is a relationship there but it’s very interesting.

@sadiarashid6320 9 ай бұрын

Sounds unbelievable..! What brand are u using, and what dose and what time do u take NMN ? Please reply

@keiraskorner4924 Жыл бұрын

sorry, we were taught at med school that any Vit B isolate (eg. NA, B6, NR, NAD, NMN) is solely excreted via kidneys because it needs a Vit B conglomerate in order to be properly metabolized. Also, the referenced studies are NOT peer-reviewed.

@paulharrisonadventuregearm5457 Жыл бұрын

Absolutely not.

@iaminkaland Жыл бұрын

You are probably getting vitamin B as well no?

@I-Dophler Жыл бұрын

One day ageing can be stopped altogether if we make that decision.

@carloscarion1748 5 ай бұрын

I won’t get into my age so much as my condition I’ve been fasting for most of my life and try to consume as much nutrient dense food as I can possibly use I exercise on a regular basis, and for most of my life people have told me that I do not look my age and in fact I don’t feel my age, and I attribute that to fasting and limiting my calorie intake, Suffice it to say I went to high school with reunion, and my mates were astonished, a few actually stating that I should leave, because I was making them all look very bad. This really kind of bummed me out because I was enjoying being around them and we’re paying no attention at all to my comparative physical condition, I think it’s important for us to learn to take care of ourselves as much as possible as we go through life, one never knows what one will encounter as it goes through their journey

@iaminkaland 5 ай бұрын

You have a great way to think about your health. Taking care of your health and physics to be able to live a long and happy life. Surely, it hurts if someone else doesn't find value in your pursuit of well-being, but at the end of the day, it's your life and your decisions, right? But staying true to your values will pay off in the long term in mental health, too. Well done. 👏

@jontpt Жыл бұрын

I think the CD-38 and methyl donor issues are pretty well known by now... Apigenin and TMG anyone?

@MrNapcsi Жыл бұрын

metylcobalamin(B12) and L-Metyl Folat(B9) is perfect and cheap metyls!Or a good B komplex with this vitamins B's!!

@jontpt Жыл бұрын

Additionally, there doesn't seem to be any NMN or NR in her formulation. That being the case, it's a pretty expensive apigenin supplement. Oh, and no dosages mentioned either. Must have been an oversight, haha

@iaminkaland Жыл бұрын

Yes the research is strong. B vitamins are great for methylation. I also take TMG with my precursors. Sleep is also very important for the activation of the salvage pathway.

@longyang888 Жыл бұрын

@@iaminkaland Selling a pricy product without any Ingredient List bottle label in the website?

@ctguitarguy8510 Жыл бұрын

@@longyang888 It's a frequent tactic by companies selling more expensive subscription based formulations to justify the higher price. I never buy something If I can't at least see an ingredient label, if not more.

@tonypolistina3357 Ай бұрын

What is the enzyme that is needed to recycle NAD?

@cnmcnm5853 Жыл бұрын

Why is the product without any Ingredient List? No in the label or in the website?

@iaminkaland Жыл бұрын

The ingrendient list is in the website in the product page: nuchido.co.uk/products/nuchido-time And also in the label of the product.

@hicoteo Жыл бұрын

Sounds like there is no shortcut without interrupting some feedback loop. It seems we need to study what is causing the nad decrease after birth.

@iaminkaland Жыл бұрын

definitely. good point.

@theancientsancients1769 Жыл бұрын

@@iaminkaland Well Islam says life clock starts while already in your mother's belly 😃 and heaven gateway is at the feet of your mother.

@mhadden 10 ай бұрын

Keto for inflammation, TMG + NMN

@iaminkaland 10 ай бұрын

TMG is amazing

@Corteum Жыл бұрын

How is NAD levels in the body measured? Is it accurate? How much it costs to measure?

@iaminkaland Жыл бұрын

You can check DONOTAGE NDA test. I have a discount code INKA. Gives -10% off. donotage.org/product/at-home-nad-test-kit/

@malcolmwhitehead7225 11 ай бұрын

Please Dr.C. Can I now actually BUY SOME Nuchido? How???

@luckssj Жыл бұрын

My NAD raised to 100 by taking NMN and Fisetin

@moniryousefian8782 Жыл бұрын

Could you please share which brand n what dosage you use and for how long?! Greatly appreciated 🙏

@luckssj Жыл бұрын

I use Do Not Age at 500 for NMN. I took it three times a day for three months and now just once a day to maintain. I take Fisetin once every other day.

@Insomniac4791 Жыл бұрын

How do you test for this?

@luckssj Жыл бұрын

@@Insomniac4791 I sent it in to a lab for testing

@TheHorrorsPersistButSoDoI Жыл бұрын

Hi, one question. My family (4 members) started taking nmn, resveratrol, little bit of olive oil and black pepper mixed together. We all took same doses (500mg nmn and 150mg trans res.). Two of us had headaches, one of those two had fever also and starting to get blue color nails and seems like blood from that person is thinner and lighter. What could be possible answer to this?

@iaminkaland Жыл бұрын

I am sorry I don't know

@brentflowers7612 3 ай бұрын

Too much nitric oxide it sounds like.

@simo4068 Жыл бұрын

someone summery pls

@davidmanning1724 Жыл бұрын

Will the Doc be attending the London organic I think starting show April 16??

@alfredf329 Жыл бұрын

What abt Vit E supplement ? It's an anti-ageing vit ? I am a practising Dr .

@iaminkaland Жыл бұрын

Not any direct anti-aging properties but could be good for counteracting inflammation etc. but studies show no effect on lifespan

@user-md2et1yr3v 7 ай бұрын

Any idea which you

@Kermit_T_Frog 10 ай бұрын

I have been taking NMN for a year now, and I can't tell that it does a damn thing. Pretty certain that it is a waste of money for the young and healthy. It MIGHT be of limited benefit for the old and morbidly obese. I have to confess that I'm taking about 1 gram a day. Could be that a larger dose is necessary to get noticeable benefits.

@iaminkaland 10 ай бұрын

For the young and healthy, NMN alone will not probably do much. If you have a good balanced sleep, exercise, recovery, and diet, your body recycles NAD during your sleep. NMN will also not work if you over-exercise, don't exercise, don't sleep, or have inflammation, in which case the NAD recycling is not optimal. I think Dr Conlon mentioned here that for young people it's more important to ensure an optimal NAD recycling (the salvage pathway). Their supplement does not even contain NMN, it only contains ingredients that help the body recycle NAD naturally. Hope it helps :)

@normacastillo7895 Жыл бұрын

If the Nuchido so-called clinical studies were genuinely useful they would be able to be published in good peer reviewed publications. I have been asking for this for several years now, and nothing has appeared. What you read on their website or hear in Dr. Conlon’s interviews is merely unsubstantiated advertising for their products with no published evidence to support their claims. Buyer beware!

@iaminkaland Жыл бұрын

Yes I understand your concern. One thing to note is that trials take time and are expensive. Most supplement marketing that claims that supplement supports "X" and "Y" are not backed by a scientific research by the manufacturer per se, but instead, the data comes from external research that's not specific to that supplement.

@nuchido2094 Жыл бұрын

Hi, the peer reviewed paper of our clinical trial is in the process of being published, as you can appreciate this is a time consuming process which is beyond our control. We wanted to share the results before releasing the published paper as we know many of our audience were keen to see the results. Dr Conlon is a published scientist and has several peer reviewed papers discussing NAD+ restoration. We will announce when the clinical trial paper is available.

@ranghashalatr142 Жыл бұрын

How can we get longevity madisine in Asia nepal and Qatar

@Kongstrong519 Жыл бұрын

would you say NMN at 28 would be beneficial? My thought process is to maintain NAD levels instead of waiting for them to drop. Some people say its to early for me to take it...Thoughts?

@iaminkaland Жыл бұрын

I was thinking exactly the same question at 29. I am 30 now. I take NMN when traveling, stressed, or have more life demands. I don't take it daily. But Dr. Conlon suggested that around 30 is a good time to start thinking about it more, so I am doing a lot more research on it atm. At this age, I am focusing on daily exercise and sleep as the number 1 (2) tools. Building muscle, daily steps, and 8 hours of sleep. That activates the salvage pathway. So my educated guess is that first focus on exercise, 10 % calorie deficit, and sleep. and then supplements when more demands. OR, you could do a biological age test, try the supplements, keep everything else constant, and see if your biological age reversed and you feel better.

@Kongstrong519 Жыл бұрын

@@iaminkaland awesome, that's a great point. Thanks for the info! Where would you recommend doing the biological age test? I only know of Inside tracker

@iaminkaland Жыл бұрын

@@Kongstrong519 @siimland knows all about these.

@theancientsancients1769 Жыл бұрын

@@Kongstrong519 You are never to young to start! I started with anti aging regimen when I was 19 and when I was 35 people thought I was 22. In your case you can take Nicotine Acid or NR, but I would be cautious of NMN as it lacks enough research unlike NR which boost NAD too.

@Kongstrong519 Жыл бұрын

@@theancientsancients1769 awsome! Thanks!

@markbr5898 Жыл бұрын

Must say I loved how Nichola pronounces "mitochondria". Do you say "Niʔola" as well?

@ranghashalatr142 Жыл бұрын

Its make longevity

@ranghashalatr142 Жыл бұрын

Please miss sent madisine for nepal and Qatar

@willyouwright Жыл бұрын

This is a perfect example of a sale's pitch. These people have no desire to help us. It's just about pumping nmn.. it's sad..

@iaminkaland Жыл бұрын

Respectfully, we talk about biological mechanisms that boost your cellular NAD levels. We point out that there's no use in "pumping NMN" without exercise, low-inflammation, and sleep. And that it's not necessary for all ages. We review the cellular mechanisms behind NAD boosting and look into the studies of NMN and NR and whether they are valid. The conclusion is definitely NOT pumping NMN if you have root cause issues. However, we also acknowledge the hundreds of research studies showing that it can boost NAD in many cases.

@massimousan9226 7 ай бұрын

Did you or anyone try Time+ and, if yes, can you share your experience on the effects?

@iaminkaland 2 ай бұрын

I tried it and liked it but unfortunately don't have NAD data

@massimousan9226 2 ай бұрын

@@iaminkaland Thanks foe the feedback. more specifically, did you notice an increase in blood pressure?

@iaminkaland 2 ай бұрын

@@massimousan9226 No, not really. But I took only 2 capsules instead of 6 per time

@massimousan9226 2 ай бұрын

@@iaminkaland me too.. I'm on two capsules a day...

@iaminkaland 2 ай бұрын

@@massimousan9226 Does it affect your blood pressure?

@user-md2et1yr3v 7 ай бұрын

How can I get in Nepal longavity subliment

@iaminkaland 7 ай бұрын

AIWO health (Chennai) probably delivers

@user-md2et1yr3v 7 ай бұрын

@@iaminkaland can it provide me at nepal

@user-md2et1yr3v 7 ай бұрын

How can I contact him

@MsHenryoh Жыл бұрын

Bravo, Fancy words about snake oil, one of many of Sinclair's ways to extract monies from the elderly USA population

@iaminkaland Жыл бұрын

Hmm there are studies so not sure about snake oil

@drmorales3009 7 ай бұрын

What about NAD iv infusion?

@iaminkaland 7 ай бұрын

Great question. Don't know about that. I hope I can find some expert research scientists to discuss it in a future episode.

@pienke_1232 Жыл бұрын

Can you have fresh parsley Juice or drinking thee does it work the same?

@pienke_1232 Жыл бұрын

@@ThierryPianoSolo you know what rootin is and which one best to get?Thank you!

@unclewerner Жыл бұрын

@@pienke_1232 I was justing looking it up... Rutin is also called "quercetin-3-O-rutinoside". You get it as flower extract from Sophora Japonica flowers.

@iaminkaland Жыл бұрын

Not sure if it concentrated enough

@ranghashalatr142 Жыл бұрын

Is it avilable in Asia miss

@iaminkaland Жыл бұрын

I don't know

@ranghashalatr142 Жыл бұрын

@@iaminkaland when avilable on Asian countries

@ranghashalatr142 Жыл бұрын

@@iaminkaland its naver get on Asian contries miss

@ranghashalatr142 Жыл бұрын

@@iaminkaland some people say I delivery it if you pay first money you don't no

@darrennicholson7203 Жыл бұрын

Cant recommend Nuchido time plus any higher. Amazing product

@iaminkaland Жыл бұрын

Thanks for sharing!

@StraitjacketFitness Жыл бұрын

Just another comment and a Like for the algo. Stay shredded brahs (and brahettes), we're all gonna make it. Peace. 0:00 .... .... .... ....

@iaminkaland Жыл бұрын

Always appreciated 🙏

@mailaimmonen5921 Жыл бұрын

🥰

@iaminkaland Жыл бұрын

❤

@user-md2et1yr3v 7 ай бұрын

How can I get in Nepal fuck it

@iaminkaland 2 ай бұрын

Check AIWO clinic (chennai india). They can post it. aiwo.com/

@JoseGonzalez-wl8pw 7 ай бұрын

😍🥰🥰🥰🥰🥰🥰🥰

@willyouwright Жыл бұрын

Please don't waste your time watching this ad.

@iaminkaland Жыл бұрын

Same reply here as to your previous comment; Respectfully, we talk about biological mechanisms that boost your cellular NAD levels. We point out that there's no use in "pumping NMN" without exercise, low inflammation, and sleep. And that it's not necessary for all ages. We review the cellular mechanisms behind NAD boosting and look into the studies of NMN and NR and whether they are valid. The conclusion is definitely NOT pumping NMN if you have root cause issues. However, we also acknowledge the hundreds of research studies showing that it can boost NAD in many cases.