Why aren't educational animated movies to this quality more common? I love these videos, it's nice to visualize the knowledge we have but can't observe with our eyes.

I am dumbfounded by the complexity of this thing

People are impressed by the structures themselves, but what always impressed me the most was how these pieces fly around throughout the vast space of the cell and zero in on the correct areas with extreme precision, and with no visible mechanism to bring them together. What makes it even more impressive is that 85% of the contents are edited out in these videos. So what looks clear and open is really quite densely packed and extremely active.

This is covered on the last exam in cell biology. Kind of sad to see the thing you have become so attached to throughout the semester kill itself, lol.

It's two dofferent signal pathways described here. The one started with the T-cell is the extrinsic pathway, the one induced by cytochrome-c released is the intrinsic pathway. They both result in caspase-3 activation and protein and cytoskeleton cleavage.

The sound design on this is other worldly.

The poor cell was bullied into suicide by the T cell smh, we live in a terrible world

Simply mind blowing what the body does.

I had apoptosis once but I cured it and now I'm immortal.

It seems so apocalyptic.

Really kind of sad to watch, but very impressive. How amazing our bodies are... Also is it just me or would "Death Ligand" be a great name for a band?

Exceptional work! Hats off to the entire team, particularly the animator.

My first time watching a cell die.

Cells are so awesome! "Attention: You have been discovered to be diseased, and are scheduled for deletion. Please attempt to do as complete a job as possible." "Command has been received and verified. Thank you for the notification. Now proceeding to self-destruct..."

We love this animation of the apoptotic cascade! It is a very helpful training tool for our company, which specializes in apoptosis and caspase assays. Thanks!

i cried watching this T.T

I can't explain it, but there's something that feels almost sacred about programmed cell death

All this work being done Unbeknownst to us Is simply amazing.

This seems a lot like a very complex 3-dimensional cellular automaton!

Was this directed by David Lynch?

I'm studying apoptosis at the moment in my course and having to write at the mo about cascade 8 so this is helpful to visualise things, I love this type of visual aid. Love the animation many thanks.

4 minutes of flying dip n dots

This is literally one of the coolest videos, ever

So mind-boggling. Again, thank you all so much for bringing this to us. It really is amazing to see a “death ligand”. ❤️ all the videos, it is so fantastically complex!

This is so freaking amazing, the best way to learn it visually!

This almost felt like I was watching a horror film - creepy!! But excellent animation and really helps bring the story to life.

thanks the video was very informative :) but is it just me or was this really scary ?? :D

I LOVE the sound effects! My cells sound just like that, too.

It's amazing how tightly controlled this process is

Brilliantly done! Many thanks

Fantastic! I've been learning about Apoptosis on Coursera and this video really helps me to understand the process.

What an amazing video! Thank you for sharing!

an absolutely awesome video - thank you!

One thing i guess i never considered is that the cell membrane is still hydrophobic, which is probably how a lot of viruses can end up having their own shield of protein or other means of reproduction even after the cell has been destroyed. But thats very clearly shown here with how the cell still tries to keep its form even after its "popped"

So there are two pathway shown here. The first one was the extrinsic pathway activated by Killer T cells and the second was the intrinsic pathway which is activated by p53 activating the production of BH3 proteins which form a channel on the outer membrane of the mitochondria which allows for release of cytochrome c. Apoptosis ends with phagocytes eating the bleb or little vesicles at the end. The phagocyte should have been included because apoptosis leaves no trace of the cell behind after it is destroyed. This is a big difference between apoptosis and necrosis.

Thank you so much 🙏🙏 amazing representation 👍👍👍

2:27 amazing sound choice

This youtube channel is still the same😊😊thanks for being consistent in all these 12 years.

Coolest video I've seen this year! I love Biomedical Science, thank you!

Your video is just amazing. I cannot even explain your perfection in words. Thanks alot for sharing such a nice video 👍👍👍

Love it how it shows the complexity of cell death beautifully...

God, this is like the cellular 10 plagues. Perfect sound design

Excellent presentation beyond the limitation

Amazing simulation

Im studying this and wow the simulation really makes it feel more real if that makes sense Anyway great video 👍

It’s so satisfying how they just cling to that cell

why is the music so ominous

Love these videos. Yet, I can see how it can be difficult to follow if you're not familiar with the process already.

awesome!!! great job guys, thank you so much

I like how the mitochondria is just... "We're dying? Alright, I'll make it faster"

What an amazing video!! Great job.

Wondeful Biochemistry with many details!

These animations are SO GOOD!!

Why it feels like I'm watching a horror movie and there is an intense death scene and the back sounds are effecting in its way.

Oh my goodness. I've just found the best channel on KZfaq 😍😍😍

Very informative. Thank you.

I am writing a book TBI - A clinical Approach to Diagnosis and Treatment. Find me at tbimedlegal and have spent the past 6 weeks reading articles on Apoptosis, Necrosis and Authphagy. Your film is excellent and makes sense. When I return to Melbourne with Pathlabs, I owe you a tall one for the efforts and accomplishment... Excellent work..

Great! Thanks for making.

AMAAAZING. Makes me want to take a college course on micro biology

Amazing video, my best compliments to the authors. I highly recommend to watch it while playing the video "Craig Armstrong - Escape (Full Version)" instead of the original audio, it becomes much more emotioning! =]

Wow! That was incredible

Beautiful, thanks

Anyone else get shivers from watching this? My face felt tingly...

fantastic video

Gave me a major horror film vibe. Awesome stuff.

Very good illustration about how a bad cell dies by associated proteins and substrates activation for initiate apoptosis.

this straight up gives me anxiety but I can't look away

U guys are brilliant

Great animation folks! I'm using all these animations to study for the USMLE, haha! :)

This is the best and most accurate simulation of apoptosis I have seen and I'm a medical student.

Great video!!!

Amazing video, liked so much. Also the comments section feels like home

This video is amazing!!!! very very beautifu

Good work!!

Amazing!

Beautiful

Mind boggling!

i stumbled this video, and i'm no biology enthusiast, but those animations are much better than anything pixar has ever created.

This is amazing!

This video needs more views.

For some reason this is really, really scary. Great vid though, really eye opening!

Apoptosis- The programmed cell death. Indeed how well programmed. I’m shooketh.

What a masterpiece!!!

the best audio

Very good, I am glad that I know how to get rid of all of the trash 🗑

Incredible 👏👏

FASCINATING !!! 💥💯💢💫💫⚡

2:54 >I'm putting together a team, for one last job.

I have subscribed just after watching your cell videos they are awesome

Thank you,good video

stunning

thanks

"Death Ligand" would be a cool name for a metal band

Beautiful algorithms there in the programmed cell death.

I'm a software engineer and found this animation fantastic. Nice to learn new things.

The sound track really made me feel like I was witnessing a cell murder

Josss

It was very helpful for me because scheme from my handbook wasn't clear.

Terrifying yet fascinating...

I've noticed that there are a few comments here about not understanding what's going on. Here's the Sparknote's version. Basically it is a cascade of proteins activating other proteins. Eventually, the end product protein breaks down the cytoskeleton of the cell, which determines the cell's rigidity and structure, causing the cell to essentially disintegrate.