Why aren't educational animated movies to this quality more common? I love these videos, it's nice to visualize the knowledge we have but can't observe with our eyes.

I am dumbfounded by the complexity of this thing

It's two dofferent signal pathways described here. The one started with the T-cell is the extrinsic pathway, the one induced by cytochrome-c released is the intrinsic pathway. They both result in caspase-3 activation and protein and cytoskeleton cleavage.

The sound design on this is other worldly.

This is covered on the last exam in cell biology. Kind of sad to see the thing you have become so attached to throughout the semester kill itself, lol.

People are impressed by the structures themselves, but what always impressed me the most was how these pieces fly around throughout the vast space of the cell and zero in on the correct areas with extreme precision, and with no visible mechanism to bring them together. What makes it even more impressive is that 85% of the contents are edited out in these videos. So what looks clear and open is really quite densely packed and extremely active.

The poor cell was bullied into suicide by the T cell smh, we live in a terrible world

Simply mind blowing what the body does.

It seems so apocalyptic.

Exceptional work! Hats off to the entire team, particularly the animator.

Really kind of sad to watch, but very impressive. How amazing our bodies are... Also is it just me or would "Death Ligand" be a great name for a band?

I had apoptosis once but I cured it and now I'm immortal.

My first time watching a cell die.

Cells are so awesome! "Attention: You have been discovered to be diseased, and are scheduled for deletion. Please attempt to do as complete a job as possible." "Command has been received and verified. Thank you for the notification. Now proceeding to self-destruct..."

We love this animation of the apoptotic cascade! It is a very helpful training tool for our company, which specializes in apoptosis and caspase assays. Thanks!

I can't explain it, but there's something that feels almost sacred about programmed cell death

This is so freaking amazing, the best way to learn it visually!

So mind-boggling. Again, thank you all so much for bringing this to us. It really is amazing to see a “death ligand”. ❤️ all the videos, it is so fantastically complex!

This is literally one of the coolest videos, ever

i cried watching this T.T

All this work being done Unbeknownst to us Is simply amazing.

I'm studying apoptosis at the moment in my course and having to write at the mo about cascade 8 so this is helpful to visualise things, I love this type of visual aid. Love the animation many thanks.

Was this directed by David Lynch?

Brilliantly done! Many thanks

What an amazing video! Thank you for sharing!

Fantastic! I've been learning about Apoptosis on Coursera and this video really helps me to understand the process.

It's amazing how tightly controlled this process is

This seems a lot like a very complex 3-dimensional cellular automaton!

an absolutely awesome video - thank you!

4 minutes of flying dip n dots

Love it how it shows the complexity of cell death beautifully...

Thank you so much 🙏🙏 amazing representation 👍👍👍

So there are two pathway shown here. The first one was the extrinsic pathway activated by Killer T cells and the second was the intrinsic pathway which is activated by p53 activating the production of BH3 proteins which form a channel on the outer membrane of the mitochondria which allows for release of cytochrome c. Apoptosis ends with phagocytes eating the bleb or little vesicles at the end. The phagocyte should have been included because apoptosis leaves no trace of the cell behind after it is destroyed. This is a big difference between apoptosis and necrosis.

I LOVE the sound effects! My cells sound just like that, too.

Excellent presentation beyond the limitation

God, this is like the cellular 10 plagues. Perfect sound design

This almost felt like I was watching a horror film - creepy!! But excellent animation and really helps bring the story to life.

awesome!!! great job guys, thank you so much

2:27 amazing sound choice

Beautiful, thanks

These animations are SO GOOD!!

Your video is just amazing. I cannot even explain your perfection in words. Thanks alot for sharing such a nice video 👍👍👍

This youtube channel is still the same😊😊thanks for being consistent in all these 12 years.

Love these videos. Yet, I can see how it can be difficult to follow if you're not familiar with the process already.

Amazing simulation

why is the music so ominous

I like how the mitochondria is just... "We're dying? Alright, I'll make it faster"

Great! Thanks for making.

What an amazing video!! Great job.

Wondeful Biochemistry with many details!

One thing i guess i never considered is that the cell membrane is still hydrophobic, which is probably how a lot of viruses can end up having their own shield of protein or other means of reproduction even after the cell has been destroyed. But thats very clearly shown here with how the cell still tries to keep its form even after its "popped"

It’s so satisfying how they just cling to that cell

Im studying this and wow the simulation really makes it feel more real if that makes sense Anyway great video 👍

Wow! That was incredible

Why it feels like I'm watching a horror movie and there is an intense death scene and the back sounds are effecting in its way.

"Death Ligand" would be a cool name for a metal band

Amazing video, my best compliments to the authors. I highly recommend to watch it while playing the video "Craig Armstrong - Escape (Full Version)" instead of the original audio, it becomes much more emotioning! =]

Amazing!

thanks the video was very informative :) but is it just me or was this really scary ?? :D

stunning

fantastic video

Gave me a major horror film vibe. Awesome stuff.

What a masterpiece!!!

Anyone else get shivers from watching this? My face felt tingly...

Oh my goodness. I've just found the best channel on KZfaq 😍😍😍

I am writing a book TBI - A clinical Approach to Diagnosis and Treatment. Find me at tbimedlegal and have spent the past 6 weeks reading articles on Apoptosis, Necrosis and Authphagy. Your film is excellent and makes sense. When I return to Melbourne with Pathlabs, I owe you a tall one for the efforts and accomplishment... Excellent work..

For some reason this is really, really scary. Great vid though, really eye opening!

Incredible 👏👏

Good work!!

AMAAAZING. Makes me want to take a college course on micro biology

Mind boggling!

the best audio

Beautiful

this straight up gives me anxiety but I can't look away

This is amazing!

Very good illustration about how a bad cell dies by associated proteins and substrates activation for initiate apoptosis.

Very informative. Thank you.

Thank you,good video

This video needs more views.

U guys are brilliant

Great video!!!

Coolest video I've seen this year! I love Biomedical Science, thank you!

Amazing....

i stumbled this video, and i'm no biology enthusiast, but those animations are much better than anything pixar has ever created.

Great animation folks! I'm using all these animations to study for the USMLE, haha! :)

FASCINATING !!! 💥💯💢💫💫⚡

Terrifying yet fascinating...

congratulation for the clip

Amazing video, liked so much. Also the comments section feels like home

This is the best and most accurate simulation of apoptosis I have seen and I'm a medical student.

Amazing

Wow it looks so pretty

this gave me chills

Apoptosis- The programmed cell death. Indeed how well programmed. I’m shooketh.

Many thanks to you guys. Its all clearer now.......much more clearer.

LIKE A catastrope...amazing!

The sound track really made me feel like I was witnessing a cell murder

2:54 >I'm putting together a team, for one last job.

Excellent

thanks