OMG thank you so much this has solve the problems I´ve been having for a month!!!! you are amazing

Finally, I understand Autodock after this tutorial..... Before that, I have tried at least 5 different tutorials on youtube. YOU ARE AWESOME

UPDATED comment: Your video has it so easy. I struggled for months to find a video like this! Thank you for the help and for this great video! I would share this video! Thanks xx

Thank you so much for making this video I am watching it after 3 years and it is very helpful for me

This is the new aspirant of docking learner sooo I hope that I’ll learn more from you inshallah

Thanks a ton. I was really struggling with the last step. Excellent way to clear for someone new in this field.

This beautiful and smart lady has helped me so much. God bless you

The only tutorial that proved helpful! TYSM

This is the best video have ever seen about docking

Thank you so much for clearing the concept. I have watched so many videos but I got the final result of docking with the help of this video only.

You are just growing amazing day by day❤❤.. best wishes...

Its really well detailed and clarified regarding steps to steps of auto docking right from the downloading the softwares to finally building a molecule. 😮❤❤❤❤

Thank you for making this tutorial, I've completed all the steps and get the results! Thank you so much 💛

Thanku so much for this video ..I was having lot of problems earlier ..but the way u mentioned every details so nicely .. thanks

Thank you so much for this video tutorial ....🤩🤗

Fantastic video... no words tq..

You explained each and every step so well, it cleared most of my doubts regarding autodock Thank you for that.😇

Thank you very much, i learned a lot of very important things. I visualized all your Videos, which I left a like for all the videos. Thank you and a thousand thanks.

Thank you so much for such a great video on molecular docking. Each step is explained so well and it has become so easy to do. Once again thank you 😇

I'm happy to come across this tutorial it's a blessing.

thank you so much, very helpful much appreciated.

Thank you I really got the results... 😄🎉. Once again thank you Mam for helping us

Thank you so much! This is the best explanation out there. Really helped me.

Solved all my issues. Thank you so much!!

You made my day and i had the first successful docking output. Thanks for your great contribution!!! The least I can do is subscribe and subscribe and ...like!

Thanks a lot mam...for your so detailed video❤❤

Thank you. Your efforts are appreciable

Thankyou very much. 🙏🏼🙏🏼

Your video is 42 minutes but I took 42 hours to watch it again and again while working

Awesome, it was so nice and easy to understand. big appreciation and thanks to you for such easy video

Thank you so much ma'am for this. ❤️ how beautifully you explain each steps.

Excellent organmed it can make possible by you only thank you so much

Explained in a very lucid way.

Hi, I am not able to save the file in pdbqt format. I tried several times and continuously it is getting saved as pdb file. Any suggestions?

your video is very nice and so easy to understand, please make video to docking metal coordinated complexes by using same tool

Thank you so much, a very good video and nice presentation.

Thank you madam little faster u explained .

Really a helpful video...clearly explained all the steps, thaks a lot.... is it possible for u to show docking with organic molecules?

Hello.. Very nice.. ❤️Thank you😘👍 But how we can analyze docking results... I mean how we can dock the ligand to protein and see their interaction. Please explain 🙏

Your videos are very good. I am getting error of bad window path name when I run autodock..what to do

Subscribed with much love and interest and enthusiasm

Thank you so much ❤️

Thank for your video! however, I found that your reference RMSD values were very high compared to those of RMSD values, respectively. Is there any problem??

Thank you for the interesting video, but might I ask, went come to the grid box it has specific value or just adjust until it fully covered the protein (for the blind docking)? Hope you can answer, thank you

Dear ur videos r v much helping Plx make videos on simulation of docked complexes using Amber

Thankyou so much...loved this tutorial

thank you very much for this video

How to find many ligand molecule are attached to a specific protein?? Is there any steps to determine..for ligand protein attachement?? Plss..help me mam...

Excellent!!!!!

Very informative mam

Thank you

Thank you for this video

This video was very helpful. Why does not ligand and protein files show up in the single folder. I save them on desktop but while choosing the file they do not show up as well.

Awesome tutorial, thank you so much

when i run the autogrid4.exe, and launch the dialogue box, the error in the cmd prompt : "Grid data file needs the extension ".fld" for AVS input" ; keeps coming up. can you help me out with this issue, i have been trying since a few days.

Hello there. Your video is very helpful, but I'm stuck at the point of Run. When I launch the autogrid it doesn't not generate a GLG file in my folder and no maps either. In case its important, my vina items are also in the same folder where all docking-related stuff is. Kindly help. Thanks

Hello ma'am please tell us The energy minimization or structure optimization of ligand (i.e. drug ) isn't necessary before doing docking? when there is a need for structure minimization of ligand & why?

Hello, your tutorial is very easy to follow, and it helps me a lot. I just wanna clarify, is the version of the autodock downloaded 4.0?

Hello , at first I want to say thanks for this video. But I have question too. My question is, "what is the procedure to make distance between protein and ligand like chimera!! ".in my grid box, both protein and ligand are present, but I think, only protein must be present in grid box

Thank u 😘😘😘😘 ,really appreciate ur efforts

thanks, excellent presentation

Please, explain how do docking with protein,which has Zn ion in active side(Adenosinedeaminase).

Thanku mam.... Its very helpful for us

Thank you for your informative tutorial, I try to make a docking for interaction between chromatographic stationary phase and the analytes however the map and glg file did not appear Do you have any solution for this problem, please Thsnk you in advance

thank you so much it helped a lot

Thank you for the awsome explanation

Really interesting, thank you very much

Thank you so much, it's verry important

Grt .....I m thankful to u

Thank you for the tutorial. I am not able to generate the protein.SA map which is why my docking run is not getting completed. Please tell me how to solve it. P.S. gpf file has the SA as receptor type and successfully completed forming .glg file.

Hello, thank you for your autodock tutorial. I am curious that why we have to delete chain B at the first time in preparing protein? Also, when i try to save the ligand as the dpf. file, it doesn't save as dpf file. Thank you.

Thanks 4 the tutorial. But how to convert your docking result to pdb format ??

Nailed it

Thank you very much for this video, .... I carried out all steps but when I arrived at grid steps exactly "set map types " failed please, can you answer me what was the problem?

This video is very helpful. Thankyou. But I am not able to launch Autogrid at the end. What should I do?

Excellent elaboration

Hello, Thanks a lot for your video. I have a couple of questions regarding docking with my protein. Please can you guide how to do docking with a heme protein like P450. I have tried, and it only works if I delete the heme and other attached groups from the protein molecule. Secondly, I have a charged ligand with a NO2 group attached to a cyclic hexane ring. The N has a +ve charge and one of the oxygen attached to the nitrogen with a single bond has a -ve charge, while the other N is double bonded to Nitrogen without any charge. How to prepare this ligand in its charged state. The software prepares pdbqt file, but docking always gives errors.

Thank you so much.it really helpful to me

Hello mam..... I am doing autodock but map files are not generating and showing as ERROR: Unknown receptor type: "Na"... Add parameters for it to the parameter library first! I am not understanding where to change in the parameter library..... Pls help me. I really need your help. Pls reply..

I appreciate this tutoring - it was helpful and interesting! One thing has been reeling in my mind since last month. May I know how to dock a metal-ligand, say, Palladium oxide or any foreign metal whose parameters have to be manually included in the AD4 parameters and bound.dat files, to a receptor (protein)? Can a molecular docking tutorial be featured, regarding this?

Thank you so much for your useful lecture. When I run blind Auto-docking, I have face one problem, the gdl file is not complete, it only 7 pages. also when I prepare the molecule and need to save it (write options) Not involved ANISOU, which started from ATOM. I wait your reply, Many thanks

maam my dlg file showed error and was of less kb size. thank you for the video it was really helpful.

U have explained everything very wonderful but I m not getting how to generate Config file..

As we all know that docking simply interaction between receptor and ligand molecule, before docking we do remove the water molecule and some other additional ligands molecule , and add polar hydrogen bond also, Afer that we dock between receptor and ligand molecules, and more negative sign give the good stability.....but sir my question is that in natural condition how water and additional ligands remove from receptor molecules and how will i add polar hydrogen also?

Thank you very much ma'am. How we will identify one lead molecular out of 100 or 1000 or more molecules

Bahut sai bahut sai 🥰🥰🥰💐💐🍫🍫

I don't know how to thank you maam, after a month I did it, Thanks a lot

I was using ozempic as my ligand against the GLP-1 receptor and i didn't have not got any results. First my ligand(ozempic) didn't show it's root. I don't know what to do

hi again the structure of ligand , must be optimized by another program such as hyperchem , gaussian...(this is step before docking)..or the optimisation is not obligatoire

hi, thanks for such an informative video. Best wishes. i m facing a problem, that .mep .glg and .dlg is formed after running the grid and docking files. pls help regarding this issue. Thanks again

Very helpful

Please tell me is it necessary k hm pdb say structure lain..main jb pdb wali ID use krti h to mera result ni hta.. Lakin jo main ny homology modeling su structure nikala tha wo use krskti h??? Please tell me

Thank you verry much. Can you help me please. Why autodock vina does not generate the dlg files foor acids such as coumaric, caffeic, gallic ...etc?

Problem existed when I choose ligand at the grid..

Thank you very much for the tutorial, it was truly helpful! But I keep getting an error: insufficient grid points. Could you please tell me how to avoid that? Thank you.

Can we perform docking on both chains or only A chain is required?

I am trying protein 2QMJ with acarbose but Docking results are not generating But for others protein the results are generated. How to dock 2QMJ with acarbose please help.

congratulaions you are very good

Madam my protein have 5 chains is there, so I will delete 4 chains or I use 5 chains for docking?

Hi, I am trying to dock a compound which contains Copper. I got this error while performing autogrid. Can you please help me with this error : \autogrid4.exe: ERROR: unknown ligand atom type Cu add parameters for it to the parameter library first!