Axsome’s Auvelity Wins FDA Approval as First Rapid-Acting Oral Treatment for Depression

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Axsome’s Auvelity Wins FDA Approval as First Rapid-Acting Oral Treatment for Depression

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Күн бұрын

The FDA has given approval to Axsome Therapeutics’ depression drug Auvelity, making it the first and only rapid-acting oral medication approved for the treatment of major depressive disorder (MDD). It is also the first and only oral NMDA receptor antagonist approved for the condition. Hear more about the approval, including its novel mechanism of action and the clinical trial data that supported its approval.
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Пікірлер: 13

@lanemcook1 Жыл бұрын

So I am a psychiatrist who does TMS. I have a patient who failed ECT, ketamine, TMS and 9 years of experimenting with every known medication for depression. The 2nd day on Auvelity he woke up and said, "I am no longer depressed or anxious." Another patient on 450 of Wellbutrin XL who never has been in remission since getting depressed, TMS and meds got response (50% reduction of symptoms) and the 2nd day on Auvelity he said, "I feel joy for the first time in 20 years." It doesn't work for everyone. Before it was approved I tried a homemade version with bupropion SR 150mg + 45mg of dextromethorphan (a real pain to get, you're limited to supply due to teenagers getting high off it) twice a day. Made them dizzy, nauseated and didn't work. Two of them I later tried on Auvelity and they had the same side effects. Not for everyone but can be a real game changer. The bupropion is mainly added to inhibit the metabolism of DMX and raise it's blood levels.

@astralfluxaf 8 ай бұрын

DMX is a rapper 😂 but yeah that’s interesting

@nirmanshrestha2038 Күн бұрын

Currently I'm taking clomipramine 200 mg and I get only 30% relief .can I take auvelity together ?? Is there any interaction ??

@lanemcook1 Күн бұрын

@@nirmanshrestha2038 No, Auvelity works by using bupropion/Wellbutrin's strong inhibition of the enzyme used to boost dexromethorphan's blood levels. Clomipramine does the same, is a 2D6 inhibitor as well so it would have to be tapered off before starting Auvelity.

@SandDuneProperties Жыл бұрын

Make sure your Doctor / Psych Professional knows how to get it APPROVED by your Insurance BEFORE they promise it to you. It's not cheap (although it should be as it is just the combo of two very available medications - Robitussin and Wellbutrin), and doesn't work for everyone. Be aware of the side effects (the reason that my wife STOPPED taking it). I wish you the best as I know far too well that TRD / MDD is a bitch!!!

@darvinreed2314 Жыл бұрын

It works great

@Yomo1343 Жыл бұрын

I'm been on a number of different antidepressants. was diagnosed with treatment-resistant depression and I'm on Viibryd 40mg (Daily) and 84mg of Spravato (esketamine) once a week. I've seen good results but lI'm looking to change vibryd because of weight gain but most importantly when I feel emotional can't cry. I'm hoping to give this Auvelity a try.

@InnaVitamina777 Жыл бұрын

So how do you release the melancholy? Very interested.

@lanemcook1 Күн бұрын

Yes, all SSRI's and SNRI's can cause emotional blunting. While that's good for people with short fuses and angry moods, it can keep you from feeling sentimental or crying. It is dose-related and sometimes lowering the dose will eliminate that side effect.