B cell activation and differentiation

Рет қаралды 350,830

8 жыл бұрын

B cell activation and differentiation -This lecture explains about the activation of B cell and the mechanism of B cell differentiation in Bone marrow and how B cell developed into the antibody making factories in immune system. It also explains the conversion of B cell into the plasma cells which is also known as the B cell maturation.
B-Lymphocytes -
derived from the bursa of Fabricius, or its equivalent,
1. ~ 10% of peripheral circulating lymphocytes
2. ~ 50% of splenic lymphocytes
3. ~ 75% of bone marrow lymphocytes
differentiation occurs in the 3rd trimester in utero & the neonatal period
all have membrane bound immunoglobulins, which attach via their Fc portion, a. IgM & IgD ~ 75%
b. IgG ~ 24%
c. IgA ~ 1%
clonal expansion and differentiation to,
1. plasma cells - which produce specific antibody, and
2. memory cells - which readily produce plasma cells to repeat challenge,
requires,
i. Ig-Fab portion attaching specific antigen
ii. antigen presented & pre-processed by macrophages
iii. modulatory signals from other cells, especially T4-cells
NB: plasma cells produce only one class of Ab which is specific for one antigen
→ theory of clonal specificity McFarlane Burnet
Ab production may occur as above, with the co-operation of T-cells
→ the antigen is said to be thymus dependent antigen
most antigens are of this class, and the Ab's produced include all classes thymus independent antibodies are exclusively of the IgM class
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@Velus1459 Жыл бұрын

First 2 things is there 1) thymus dependent 2) thymus independent 1. Thymus dependent 3 signal is there 1. BCR binds with AG and internalization (endocytosis ) those AG have spliced The MHC molecule identified and externalization of MHC molecule. And bind with TCR and CD 21 complex activation occurs (CD 21 (c3b,CD 19, CD 81) receptor activated in B cell and downstream signal activated B cell differentiation occur. 2 signal CD 40 bcell / CD 40 L ( T cell) (b cell cell division strated produced B cloned cell ) activated SHM ( somatic hyper mutation) with help of AID enzyme . And class switching (isotyping ) . This is increasing affinity towards antigen.

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Thank you so much...videos are really helpful..making my concepts clear..looking forward for more such videos...:) actually i was in search of videos explaining B-cell activation & its two mechanisms:thymus independent and thymus dependent types..if u could help it would be great..& would be grateful..and once again thankyou..

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Subscribed from 2017

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OMG ur video is sooo clear... Thank you

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@hayatahmed420 3 жыл бұрын

Thank you so much for these amazing explanation. and that means this video is B cell response to T cell dependent antigen right.

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Thnk u so much sir making it so easy to understand this concept. Keep it up sir👍

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Beautifully explained. TYSM

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@ambidurrani7224 7 жыл бұрын

it was excellent,any video about mechanism of generation of CTL,TH and Ab?

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Loved it bhaii... YOU SEEM LIKE A POLE STAR in the darkest night....

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Really wonderful teaching. My Request is to show the whole diagram at the end of the video.. it will help peoples to recollect all the points once again. Thanks