@yutong-os8mz 7 ай бұрын
a clear and comprehensive explanation. thank you so much!
@royjoseph1498 4 жыл бұрын
I adore you!!!
@lachlanmcgregor1744 4 ай бұрын
this was very very helpful
@alfianrizky117 5 жыл бұрын
so where is the positive and negative selection of B-Cell :(
@cindycuriel7164 4 жыл бұрын
Very helpful thank you!! :)
@karankalani4211 4 жыл бұрын
Great video! An immature B cell has already undergone vj recombination to produce a light chain. Let’s say v1j1. Aren’t the other segments (v2 onwards and j2 onwards) deleted during this recombination? If so, how does the immature B cell go back to a different light chain combination if it is selected for “receptor editing” ?
@WhyNot-si4pj Жыл бұрын
Great question ! In case of " receptor editing " ; the immature B cells take advantage of the " allelic exclusion " property of VJ recombination in the coding allele ! Where the excluded allele of the INITIAL VJ recombination is the one that undergoes a NEW recombination of the V & J segments ! Lord knows best !
@immadisarojini2775 3 жыл бұрын
Nice
@oliviapereira364 3 жыл бұрын
Hi! Why is clonal deletion called "clonal"? Those cells are clones of the same origin cell? Thanks, your video was very helpful and didactic!
@berenicedrabo1573 2 жыл бұрын
Where is the video following this one?
@seanireland8963 3 жыл бұрын
Is the receptor editing step negative selection or positive selection given it has to have no affinity to pass through to become mature?
@haideralfadhli9444 5 жыл бұрын
Please,i want lecturer about the avidity and affinity
@premaadhikari128 4 жыл бұрын
Brother Read kuby book
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