a clear and comprehensive explanation. thank you so much!
@royjoseph14984 жыл бұрын
I adore you!!!
@lachlanmcgregor17444 ай бұрын
this was very very helpful
@alfianrizky1175 жыл бұрын
so where is the positive and negative selection of B-Cell :(
@cindycuriel71644 жыл бұрын
Very helpful thank you!! :)
@karankalani42114 жыл бұрын
Great video! An immature B cell has already undergone vj recombination to produce a light chain. Let’s say v1j1. Aren’t the other segments (v2 onwards and j2 onwards) deleted during this recombination? If so, how does the immature B cell go back to a different light chain combination if it is selected for “receptor editing” ?
@WhyNot-si4pj Жыл бұрын
Great question ! In case of " receptor editing " ; the immature B cells take advantage of the " allelic exclusion " property of VJ recombination in the coding allele ! Where the excluded allele of the INITIAL VJ recombination is the one that undergoes a NEW recombination of the V & J segments ! Lord knows best !
@immadisarojini27753 жыл бұрын
Nice
@oliviapereira3643 жыл бұрын
Hi! Why is clonal deletion called "clonal"? Those cells are clones of the same origin cell? Thanks, your video was very helpful and didactic!
@berenicedrabo15732 жыл бұрын
Where is the video following this one?
@seanireland89633 жыл бұрын
Is the receptor editing step negative selection or positive selection given it has to have no affinity to pass through to become mature?
@haideralfadhli94445 жыл бұрын
Please,i want lecturer about the avidity and affinity