Giulia Martini, MD, PhD, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy, discusses the Phase II CAPRI 2-GOIM trial (NCT05312398) of cetuximab-based treatments for metastatic colorectal cancer (mCRC) using biomarker-driven approaches. Baseline next-generation sequencing (NGS) of tumor tissue and plasma circulating tumor DNA (ctDNA) was performed to identify RAS/BRAF V600E wild type mCRC. The study found baseline plasma NGS profiling feasible and effective in reclassifying 12% of patients, revealing molecular alterations that could impact resistance to anti-EGFR drugs. This interview took place at 2024 European Society for Medical Oncology (ESMO) Gastrointestinal Cancers Annual Congress in Munich, Germany.
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