Biotransformation, Detoxification, Metabolism of Xenobiotics

  Рет қаралды 329,621

Biochemistry by Dr Rajesh Jambhulkar

Biochemistry by Dr Rajesh Jambhulkar

5 жыл бұрын

Phase 1 Reactions
1. Oxidation/ Hydroxylation
involves cytochrome p450
examples- Oxidation of Alcohol, aldehydes, amines, aromatic hydrocarbons, sulfuric compounds, drugs
2. Reduction
examples- nitro compounds, picric acid, Chloral
3. Hydrolysis
examples- Aspirin, atropine, procaine, xylocain, DFP etc

Пікірлер: 99
@prasadhegde7559
@prasadhegde7559 3 жыл бұрын
You are the best biochem professor i have seen sir. Your lecture will be crisp and perfect. No requirement of books when heard your lectures.
@ayushdev007
@ayushdev007 7 ай бұрын
That's basically entoxification na?
@RABPD
@RABPD 4 жыл бұрын
Outstanding sir ....fully detail ...no more question left behind after watching this video
@Sonu_daily_vlog_mbbs
@Sonu_daily_vlog_mbbs 9 ай бұрын
Tere ko sab smej aa gya
@incredulous-
@incredulous- 2 ай бұрын
For questioning you must know extra from before itself
@divyangsarvaiya9388
@divyangsarvaiya9388 2 жыл бұрын
Thank you very much sir.. can't define how important you are for biochem .. gonna suggest all my jrs. About ur channel
@sharonpanneerselvam4000
@sharonpanneerselvam4000 3 жыл бұрын
Thank you so much Sir! You are great! Thank God I discovered your videos on KZfaq. I am preparing my Biochemistry Final Examination and thanks to your lectures I can understand the stuff more easily!! Thank you soo much and God Bless you! ❤️
@Dr.Vyshnavi
@Dr.Vyshnavi 4 жыл бұрын
Sir, very good explanation, thank you so much sir, keep going, all the best 👍💯-your lectures are amazing always, even the audio clarity is good 👍
@jyotikomal9398
@jyotikomal9398 3 жыл бұрын
this is life saver video sir thank you for your efforts 🙏🙏🙏
@sonudesai3310
@sonudesai3310 3 жыл бұрын
Wonderful explianation great time management
@s.h.w.e.t.a.
@s.h.w.e.t.a. 3 жыл бұрын
Thank u very much sir... Bahut hi behter samjhya apne ... Class me itne ache se clear nhi hua tha .. Bt ab koi doubt nhi h😊😊👍👍👍
@rikganguly4986
@rikganguly4986 Жыл бұрын
Dear sir, I really appreciate your reasonable effort in teaching a complex subject like biochemistry so nicely. I have a humble request, most of the textbooks show phase one as consisting of oxidation-reduction and hydrolysis. similarly phase two consists of conjugation pathways. thanking for your great effort and excellence in teaching, my humble regards.
@harshitapatnaik2115
@harshitapatnaik2115 2 жыл бұрын
Thank u so much Sir 🙏🏻🙏🏻🙏🏻 .. u r the nly teacher for whom now a days i cn cover my chapters 😇😇😇 Thanx a loott Sirr🙏🏻🙏🏻🙏🏻❤️❤️❤️
@nlnrao123
@nlnrao123 4 жыл бұрын
U made it very simple and easy to understand sir Thank you
@Tannyyyyyyyyyyy
@Tannyyyyyyyyyyy 3 жыл бұрын
Great Explanation sir.Thank you
@rachelarc8837
@rachelarc8837 4 жыл бұрын
Wow amazing! This is helpful
@vaibhavi7718
@vaibhavi7718 4 жыл бұрын
Awesome explanation 😊 Please make video on free radicals and antioxidants.
@dhx8452
@dhx8452 2 жыл бұрын
Aah ooh thalaivare
@dr.strange8311
@dr.strange8311 Жыл бұрын
Nakkuu
@shrustisoumya2895
@shrustisoumya2895 3 жыл бұрын
Sir cyt p450 enzymes are located in ER OR MICROSOMES if both option given in mcq
@hrijxy
@hrijxy 4 жыл бұрын
Sir your lectures are really helpful.✅
@DrRakeshVerma001
@DrRakeshVerma001 3 жыл бұрын
Normally,drug or xenobiotics metabolism occurs in phase 1 followed by phase 2 reactions. My question is there any drug which undergo phase 2 reaction first then to phase 1 reaction for metabolism?
@arnavgandhi7620
@arnavgandhi7620 2 жыл бұрын
outstanding, very helpful
@hardikgangwal6691
@hardikgangwal6691 5 жыл бұрын
great lecture thanks a lot 😊😊
@dattatreyomitra3906
@dattatreyomitra3906 3 жыл бұрын
thank you sir...it was really helpful
@radhakrishnanravichandran534
@radhakrishnanravichandran534 4 жыл бұрын
Awesome explanation sir...tq sir
@rajayeducation6581
@rajayeducation6581 4 жыл бұрын
Thank you sir It is very helpful for me
@_WaTeR_793
@_WaTeR_793 3 жыл бұрын
Sir your explanation is outstanding
@lordshantel185
@lordshantel185 5 ай бұрын
How do we explain the relationship between phase 1 and 2 reactions in xenobiotics?
@vishnumohanan947
@vishnumohanan947 3 жыл бұрын
Thank you so much sir very good lecture
@krishnalal9965
@krishnalal9965 2 жыл бұрын
Mast explained kiya sir ji aapne.
@avinabakarmakar
@avinabakarmakar Жыл бұрын
14:19 Doubt : Sir, you have told Formic acid is more toxic than ethanol, but in detoxification that is in hydroxylation methanol is converted into formic acid, how ????
@harshitapandey2924
@harshitapandey2924 3 жыл бұрын
Amazing work sir
@fardinqureshi535
@fardinqureshi535 3 жыл бұрын
Excellent work sir
@yvsairam7012
@yvsairam7012 3 жыл бұрын
Tq very much sir I have one doubt sir Could we take another example for reduction sir that is Conversion of nitrobenzene to amino benzene Along with your example Nitrophenol to aminophenol
@boddepallijiveeta6597
@boddepallijiveeta6597 Жыл бұрын
Tq so much sir,u saves our time😁
@alishasayyad5396
@alishasayyad5396 3 жыл бұрын
Thank you so much sir 🙏
@shadilhassan6890
@shadilhassan6890 3 жыл бұрын
Respected sir I have completed my bsc MLT I want to go for clinical biochemistry course which course is best for me MSc MLT clinical biochemistry or Msc clinical biochemistry
@Ishitajaiswal3449
@Ishitajaiswal3449 3 жыл бұрын
Sir it's a biochemistry topic but y it always related with pollutant transformation mean is biotransformation of pollution and biotransformation of xenobiotic is same
@shahabuddin6149
@shahabuddin6149 4 жыл бұрын
Super lecture Sir thanks alote
@vickimichael255
@vickimichael255 Жыл бұрын
Thanks sir this was very helpful
@jayanighangas2638
@jayanighangas2638 3 жыл бұрын
Thnku soo muchh sir🙏🙏😊😊👍👍
@Ankit.malyaj
@Ankit.malyaj 9 ай бұрын
Thank you so much sirr ❤❤❤😊😊😊
@patelafifa.9697
@patelafifa.9697 Жыл бұрын
Wooww thank you so much
@rajkumarm9829
@rajkumarm9829 Жыл бұрын
Sir pharmaceutical biochemistry notes videos
@user-nh3hq7cs2d
@user-nh3hq7cs2d 3 жыл бұрын
thank u!!
@chaudharyanshusingh9525
@chaudharyanshusingh9525 3 жыл бұрын
You are best sir ❣❣💚💚🙏🙏🙏🙏
@MMIliyas
@MMIliyas 2 жыл бұрын
It help me alot
@Lushbeauty00
@Lushbeauty00 4 жыл бұрын
thank you so much for the lecture.
@shivanagpal1163
@shivanagpal1163 4 жыл бұрын
Thank u sir 🙏
@yogeshwarikhedkar
@yogeshwarikhedkar 4 ай бұрын
In the which lesson, detoxification given ?????
@srikanth.m5487
@srikanth.m5487 5 жыл бұрын
Super sir👌👌👌
@hridoykrishnaborah2438
@hridoykrishnaborah2438 2 ай бұрын
Thank you sir❤️
@ruma7664
@ruma7664 Жыл бұрын
Thank you sir 😊
@zaidgauri5236
@zaidgauri5236 2 жыл бұрын
Thanku sir 👍🏻👍🏻
@jyoti2577
@jyoti2577 3 жыл бұрын
Nice sir 👌👌
@nityaupadhyay4823
@nityaupadhyay4823 3 жыл бұрын
Nice sr
@SOMERANDOMPREPPY
@SOMERANDOMPREPPY 7 ай бұрын
From 6:12 the important points are explained… before all are basics
@pradeepmittal7313
@pradeepmittal7313 2 жыл бұрын
Sir, how you remember all this, great
@fightiny8624
@fightiny8624 2 жыл бұрын
Sir apne ek molecule oxygen bol diya hai instead of one atom...
@Aiming-zw8xo
@Aiming-zw8xo 8 ай бұрын
Thank you sir 😊🙂
@chichu9521
@chichu9521 2 жыл бұрын
This yr we got this question sir 🥴it's a bouncer question for us
@sonam268
@sonam268 3 жыл бұрын
Thanks ☺️ sir
@visualsofautif1233
@visualsofautif1233 7 ай бұрын
Is bilirubin a xenobiotic?
@sivagurunaathan5719
@sivagurunaathan5719 Жыл бұрын
Looking like selvaraghavan❣
@dr.strange8311
@dr.strange8311 Жыл бұрын
Oombu
@shanaya6749
@shanaya6749 Жыл бұрын
detoxification itself doesnt mean converting into more toxic substance ,its a misnomer as sometimes the detoxified product might be more toxic than original form
@Prasanth2403
@Prasanth2403 8 ай бұрын
That is not detoxification it is called entoxification
@biologyisfun
@biologyisfun 7 ай бұрын
Nobody thinks this way mam😅
@sangramnayak9762
@sangramnayak9762 7 ай бұрын
As methanol converted to formic acid by oxidation which is one of the step of detoxification but result product is more toxic than methanol
@AYT110
@AYT110 5 ай бұрын
may I have ur insta id ?
@manalij8140
@manalij8140 3 ай бұрын
konala shikvaayla challi ahe tu 🤦‍♀️
@Acts-4-12
@Acts-4-12 Жыл бұрын
💜
@user-jj1ed8hf6e
@user-jj1ed8hf6e 2 жыл бұрын
Did you know smily didi...? Plz.. You must know...
@herusayshaye
@herusayshaye 3 жыл бұрын
Sir ,Are xenobiotics always undergoing detoxification??????
@herusayshaye
@herusayshaye 3 жыл бұрын
Cant they become more toxic on biotransformations ??
@yuktabodade6942
@yuktabodade6942 5 жыл бұрын
Thank u very very much sir. u listened that
@abdulhayeekhan9394
@abdulhayeekhan9394 4 жыл бұрын
Ey method biodegradation of xynbiotics ky topic pr bhi lokh skty hy....
@Kittupatel089
@Kittupatel089 3 жыл бұрын
Which book u prefer sir ??
@Rajesh_Jambhulkar
@Rajesh_Jambhulkar 3 жыл бұрын
Vasudevan
@RohitArya-dr6vz
@RohitArya-dr6vz 7 ай бұрын
If your lecture in hindi then we are hindi medium students ka bhi bhala ho jata hai.... Baaki aap likhiye english me hi
@daniyalhaider7883
@daniyalhaider7883 Жыл бұрын
bestest
@heenakanwal6777
@heenakanwal6777 5 жыл бұрын
Sir plzz video on metabolism of fructose
@vps5362
@vps5362 4 жыл бұрын
Why bilirubin is foreign compound?
@sarathgopan3592
@sarathgopan3592 4 жыл бұрын
Compounds produced in the body which are to be eliminated, e.g. bilirubin and steroids. Bilirubin is toxic to the brain of newborns and may cause irreversible brain injury. Biotransformation of the lipophilic bilirubin molecule in the liver results in the production of water-soluble (hydrophilic) metabolites excreted into bile.
@nishidwivedi4405
@nishidwivedi4405 5 жыл бұрын
Sir please upload phase 2 also ASAP 🙏🏻
@muhammadsulaiman6023
@muhammadsulaiman6023 5 жыл бұрын
Phase 2 rxns occurs in mitochondria and cytoplasm of liver cell. They are also called synthetic rxns. Conjugations of xenobiotics takes place. Mostly by UGT...
@nishidwivedi4405
@nishidwivedi4405 5 жыл бұрын
MUHAMMAD SULAIMAN I m not asking for a definition 🙄
@muhammadsulaiman6023
@muhammadsulaiman6023 5 жыл бұрын
@@nishidwivedi4405 it's not definition
@nishidwivedi4405
@nishidwivedi4405 5 жыл бұрын
Sukriya Jo bhi tha 😊
@jainilgor3178
@jainilgor3178 3 жыл бұрын
Thank you sir
@ragnarok9197
@ragnarok9197 2 жыл бұрын
🔥🔥🔥
@vishnumohanan947
@vishnumohanan947 3 жыл бұрын
Thank you so much sir very good lecture
@souravmohanty1200
@souravmohanty1200 Жыл бұрын
Thank you sir 🙏🙂
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