(side note)
Non-nitrogen containing bisphosphonates:
‣medronate (used as a bone imaging agent "Technetium Tc 99m Medronate"),
‣clodronate (BONEFOS®),
‣etidronate (Didronel® (etidronate disodium) ),
‣tiludronate(Skelid®)
Nitrogen-containing bisphosphonates:
‣alendronate (Fosamax®),
‣pamidronate (Aredia®),
‣zoledronate (Zometa®, Reclast®),
‣olpadronate (OLPADRONATE DISODIUM®),
‣ibandronate (Boniva®),
‣risedronate (Actonel®),
‣incadronate (Bisphonal®)
Discover the groundbreaking world of bisphosphonates, the frontline defenders against osteoporosis! This video delves into the fascinating mechanisms behind how these drugs inhibit bone breakdown and promote bone formation, ensuring your bones stay healthy and strong. Uncover the differences between non-nitrogenous and nitrogenous bisphosphonates, and understand the critical role they play in bone health. Learn about the potential adverse effects and essential precautions to take for safe and effective treatment. Don't miss this essential guide to safeguarding your bones and improving your overall health!
#osteoporosis #pharmacology #bones
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【Notes】
▹This video was created based on data as of January 2024, with the purpose of supporting medical students in their exam preparations.
▹It is not a substitute for medical advice.
▹Please note that thanks to the tireless efforts of researchers worldwide, this data is updated daily. ▹Unauthorized reproduction is prohibited.
【Contents】
0:00 What are bisphosphonates?
0:05 How do bisphosphonates work?
0:33 What is the chemical structure of bisphosphonates?
0:51 Non-nitrogen containing bisphosphonates, Mechanism of action
1:16 Nitrogen-containing bisphosphonates, Mechanism of action
1:32 adverse effect 1: esophagitis/gastritis
1:57 adverse effect 2: hypocalcemia
2:15 adverse effect 3: atypical femoral fracture
2:31 adverse effect 4: BRONJ
【Reference and figure】 I express my gratitude and respect for your wonderful achievements.
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Chapter 81 - Bisphosphonates: Mechanisms of Action,
Editor(s): John P. Bilezikian, Lawrence G. Raisz, T. John Martin,
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DOI:
doi.org/10.53347/rID-835
Permalink:
radiopaedia.org/articles/835
9. Neviaser, Andrew S., Joseph M. Lane, Brett A. Lenart, Folorunsho Edobor-Osula, and Dean G. Lorich. "Low-energy femoral shaft fractures associated with alendronate use." Journal of orthopaedic trauma 22, no. 5 (2008): 346-350.
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Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases,
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