Can Stem Cells Treat Parkinson’s Disease?

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Күн бұрын

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We’ve all heard about the groundbreaking ways in which stem cells have been used to treat previously incurable conditions. Is Parkinson’s next on the list? Share your take on this research in the comments below.
Jodie Forbes, living with young onset Parkinson’s, strikes gold once again with Roger Barker - Professor of Clinical Neuroscience at the University of Cambridge. Watch until the end to hear how you can help fight the barriers to this treatment being readily available to you.
Chapters:
00:00 3 ways to replace dopamine cells
01:10 What are stem cells?
03:19 Implications of stem cell therapy
05:32 Why aren't stem cells a standard treatment?
08:01 Current clinical trials
10:20 When will this become a treatment?
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*The information in this video represents the views and opinions of the participants. The content is not intended to be a substitute for professional medical advice.
Any research discussed in this content may be subject to participant interpretation and conclusions may change as new research emerges.
Never delay seeking medical attention or disregard medical advice because of the content in any of our videos.
LivedHealth's Parkinson’s video programme is proudly supported by Wellcome.
#Parkinsons #ParkinsonsDisease #MovementDisorder #Neurology #Neuroscience #ClinicalTrial #DrugTrial #StemCells #StemCellTransplant

Пікірлер: 27

@uquantum 2 ай бұрын

Terrific content and well-presented!

@annegordon6725 Жыл бұрын

I found this video extremely informative having been diagnosed with PD in June 2021. I pray for a cure for this terrible disease in years not decades.

@LivedHealthParks Жыл бұрын

I completely agree. It would be wonderful to see a cure become available in the near future. In the meantime, we'll stay positive and focus on the treatments and therapies that can help manage the symptoms and bring you updates as and when they are available 🤞

@annegordon6725 Жыл бұрын

@LivedHealth Parkinson's Look forward to the updates. It's hard to stay positive all the time but the cure/slowing progression cure has to be there 🙏

@LivedHealthParks Жыл бұрын

So are we 🤞 It takes serious mental strength to stay positive, and it's definitely not possible 24/7. Don't be too hard on yourself if you have an off day!

@amymac3099 Жыл бұрын

Could this treatment help corticobasal degeneration as dopamine is a big factor in this disease

@LivedHealthParks Жыл бұрын

Thanks for your comment, Amy. It's hard to generalise from Parkinson's to CBD since the latter is caused by a build up of a specific protein (tau) and can be secondary to other neurodegenerative conditions like Alzheimer's. If you're interested to know how this differs, we have a video all about the causes of Parkinson's ➡ bit.ly/WhatIsPD_LH

@davidlo168888 8 ай бұрын

Stem cell therapy is to help those endogenous stem cells to clear away so-called inhibitory molecues, such as AGEs (advanced glycation endproducts), ALEs, etc. so that its regenerative potentials can be triggered for regeneration, i.e. dedifferentiation, differentiation and proliferation. Autologous and/or allogeneic stem cells therpay are entirely wrong and will cause horrible side effects.

@AsadPlays777 Жыл бұрын

Thanks for sharing. Can you guide us on when will the stem therapy be available on commercial scale

@LivedHealthParks Жыл бұрын

Glad you enjoyed! If you watch chapter 6 (from 10:20) Jodie asks this key question. You may also find the penultimate chapter (8:01) discussing ongoing clinical trials valuable.

@user-ho2hl8mh1o Жыл бұрын

I. Have a cord blood for my two sons circa 2002, 2007 and has been cryogenically stored . I’m told that they could retrieve stem cells from this cord blood for my pd treatment. How do I determine this viability and who could perform such a process and test me for cord blood stem cell generation? Thanks for your earliest reply, John.

@LivedHealthParks Жыл бұрын

Hi John, that sounds really interesting and a great way to harvest stem cells. I'd suggest speaking to your local healthcare provider about this or reaching out to a specialist online if you haven't already about how to progress. Keep us updated and we can share this with others!

@annasophiaa.7142 9 ай бұрын

What specific studies are being referenced here? Is there a pubmed link?

@LivedHealthParks 9 ай бұрын

There are many papers on this topic, but this one gives a good overview: www.cell.com/cell-stem-cell/pdf/S1934-5909(17)30382-X.pdf

@ahmedi9407 10 ай бұрын

Hope that

@user-qc3mg3pp2s 11 ай бұрын

IF a therapy was developed to coerse other cells in the brain to become dopamine cells, what would stop a hypersaturation of the coersed cell? If cell 2a is coerced how can it be limited to assure ALL 2a cells don't transform, thereby starving the brain of the cells original job? Im 6 years post diagnosis.

@greyeyed123 7 ай бұрын

I understand your concern, but there have been many trials, animal experiments, etc., so if this was a real problem or concern, it would be made clear by now, even to us lay people. My mother is on year 13 (almost 14) post diagnosis, getting Deep Brain Stimulation surgery in '21.

@Ann-sf6od 4 ай бұрын

Do trials involving stem cells appear to indicate a reversal of some symptpms or merely slowed progression?

@LivedHealthParks 4 ай бұрын

Yes, by replacing some of the lost dopaminergic cells, motor symptoms have been significantly improved in some patients. The disease itself is still present and the transplanted cells also start to show signs of Parkinson's but because the disease progresses slowly this doesn't matter so much.

@ascenjoe 3 ай бұрын

Are you suggesting that the results could continue to improve after 5 years? And possibly last for 29 or more years? Thank you very much!

@LivedHealthParks 3 ай бұрын

My understanding is that the original cell transplantation experiments done as far back as the 1980s using foetal nerve tissue restored dopamine production in some patients for 15-18 years. See for example www.cell.com/fulltext/S2211-1247(14)00419-7. After some years, the transplanted cells also develop signs of Parkinson's but they are still able to restore motor function for a period of time that is significantly beneficial for patients. The challenge now is to achieve the same thing with stem cells and turn this into a reliable mainstream therapy. I personally think this has a good chance of becoming a reality. Jodie.

@ascenjoe 3 ай бұрын

@@LivedHealthParks thank you!