"This video explores specific biochemical sources of cancer-causing mutations. Topics looked at here will be genes involved in cell cycle regulation and arrest, as well as signaling cascades within a cell which affect pro- or anti-proliferation signaling. Finally, clonal evolution and factors influencing the survival and formation of malignancies are discussed. This information may be found in all editions of Benjamin A. Pierce’s Genetics: A Conceptual Approach. Further readings which informed the creation of this video may found below:
Sources:
Pierce, Benjamin A. (2020). Genetics: A Conceptual Approach (7th ed.). Macmillan Learning.
Nelson, D. L., & Cox, M. M. (2017). Lehninger principles of biochemistry (7th ed.). W.H. Freeman.
Information on RAS mutations:
Prior, I. A., Hood, F. E., & Hartley, J. L. (2020). The Frequency of Ras Mutations in Cancer. Cancer research, 80(14), 2969-2974. doi.org/10.1158/0008-5472.CAN...
Information on p53:
National Center for Biotechnology Information (US). Genes and Disease [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 1998-. The p53 tumor suppressor protein. Available from: www.ncbi.nlm.nih.gov/books/NB...
Information on VEGF:
Duffy AM, Bouchier-Hayes DJ, Harmey JH. Vascular Endothelial Growth Factor (VEGF) and Its Role in Non-Endothelial Cells: Autocrine Signalling by VEGF. In: Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000-2013. Available from: www.ncbi.nlm.nih.gov/books/NB...
Information on BRCA1/BRCA2:
www.cancer.gov/about-cancer/c....
Information on Telomerase:
Srinivas N, Rachakonda S, Kumar R. Telomeres and Telomere Length: A General Overview. Cancers. 2020; 12(3):558. doi.org/10.3390/cancers12030558"