Carbon Dioxide Transport

Рет қаралды 310,477

10 жыл бұрын

Brief introduction to carbon dioxide transport in the blood. Bicarbonate buffer system perspective.
Topics Discussed:
Bicarbonate buffer
Carbon Dioxide transport
Oxygen Transport
Chloride shift
carbonic anhydrase
red blood cell
co2
h2o
hemoglobin
*Brought to you by Anatomy On Demand
/ @anatomyondemand

Пікірлер: 161

@Virgo8270 6 жыл бұрын

literally the BEST explanation of what happens in the blood buffer system both chemically, mechanism, and biologically. Thank you!!!!

@MegaPlika 9 жыл бұрын

far better than any of my teachers have ever explained it thanks

@markyounger1240 8 жыл бұрын

One of the best lectures I've seen on the subject.

@anitamcfly4671 6 жыл бұрын

I saw a comment asking about where the CO2 in the blood comes from and where it goes, so I thought I'd comment in case anyone else watching wants to know. CO2 is a waste product of glucose metabolism in cells and it accumulates in the tissues. When oxygen carried by hemoglobin (in red blood cells in plasma of blood) passes thru the body, it gets ejected at places where the CO2 is accumulated. But the CO2 accumulation itself doesn't trigger the release of oxygen. The CO2 actually enters the blood plasma and from there it enters red blood cells where its broken down into carbonic acid and then further into protons (H+) and bicarbonate. The increase in this proton (H+) concentration is what triggers the hemoglobin to release the oxygen that it's holding, into the tissue. After delivering the oxygen to the tissues, the red blood cell takes up the CO2 and the blood flow continues to the heart from where it will enter the lungs to be exhaled.

@1joseheli 2 жыл бұрын

I stumbled upon your explanation and it was by far the most concise yet informative and detailed.

@airotkiv 5 жыл бұрын

So well explained that even I as a non-native speaker could get it. Thank you!

@crystalawhite1 5 жыл бұрын

SO helpful! I was having trouble understanding this in lecture and from the textbook, but the way you explained it made it easy to grasp. Thanks!

@AndreaaaNS 6 жыл бұрын

this was great! all of the other videos on this subject that I found on youtube can't match yours. this is the complete cycle from the tissue to the lungs, and no one else has talked about the whole cycle. thanks!

@medicalvideos1640 6 жыл бұрын

AndreaaaNS please do watch my video on transport of carbon dioxide kzfaq.info/get/bejne/icldmpmAzM2Rgn0.html

@JDPowerFitness 6 жыл бұрын

First semester nursing school student here. great video :)

@loisroberts4234 3 жыл бұрын

In the uk we have to do this at 16/17, it’s so difficult! Good luck with nursing school :)

@7Songsevensong 4 жыл бұрын

While many videos explain the conversion of carbon dioxide in the red blood cell, this is the first I found that explains how the conversion is reversed in the alveoli. Thank you.

@samh448 4 жыл бұрын

Thanks for the KZfaq videos! You talk about science the way people talk about movie twists. You’re so excited and passionate! It helps me see just how incredible our body is, all the things that have to happen in order for us to function!

@revision7685 Жыл бұрын

9 years later and it's still being used

@romeolhk1008 7 жыл бұрын

Still can't believe you gave us so much information with only 1 picture, great work!

@jatin8730 3 жыл бұрын

Thnku very much. The thumbnail itself suffice to know the mechanism. Thnks🙌🙌🙌love from india

@Matt-tv5ww 7 жыл бұрын

Such a phenomenal explanation, the diagram was perfect and you simplified it all very easily. Thanks!

@TacticalDraws 6 жыл бұрын

Thank you so much, very clear explaination. I now understand the chloride shift and carbon dioxide transport! Better explaination than my teacher

@mptoast4061 Жыл бұрын

Thank you so much! For some reason it wasn’t clicking until I watched your video.

@fitfanat 9 жыл бұрын

Thank you very much, it made carbon dioxide transport easier to understand.

@adityadharankar8841 5 жыл бұрын

I had this diagram in my CIE endorsed textbook and it wasn't that easy to understand and thought wasn't making any sense. After I watched your video it made it easy for me to understand the concept.

@carlahinojosa7366 Жыл бұрын

What beautiful way to explain this process, thank you so much!!

@erinsperberg9 5 жыл бұрын

I have a feeling this topic is going to be the essay question on my final because my teacher talked a lot about this today. He made no sense at all. You explained this so well, thank you.

@KM-ze3tr 5 жыл бұрын

Thank you! Very simple yet informative

@hawtnurse6385 7 жыл бұрын

Great explanation thx really helped

@hazeldiaz4896 7 жыл бұрын

Your explanation of this process is great! Thank you!!!

@zsebi696 7 жыл бұрын

Thank you! thank you! Really great explanation, far better than any other I have seen. Clean, simple and makes sense. Appreciate it very much!

@dhandapani9870 Жыл бұрын

Thank you so much. You’re such a blessing

@dianasalazar4488 5 жыл бұрын

Thank you! This will help me with my final, you explained it easier than the book and my teacher combined.

@nanglk87 9 жыл бұрын

This is very helpful. Thank you so much!

@tinatanner244 9 ай бұрын

Great video. Thank you!

@MartialBachoffner 7 жыл бұрын

Thanks for this video. I want to study Respiratory Therapy and this will help me a lot.

@ellenfox6714 9 ай бұрын

Super helpful! Thanks so much!

@fatimatmato4673 3 жыл бұрын

a very good and helpful video 100 percent. thank you so much

@BiologyMusicVideos_educational 6 жыл бұрын

EXCELLENT VIDEO!

@ahedshdooh604 3 жыл бұрын

incredible explanation !!!

@cidneyko9977 5 жыл бұрын

Awesome video! This helped so much more than my teacher did in lecture!!

@madison-6012 Жыл бұрын

such a good explanation!

@MadameMcKracken 6 жыл бұрын

that was ultra clear and helpful, many thanks

@richardtverberg16 6 жыл бұрын

Great video! thank you so much!!

@christiandacanay6278 2 жыл бұрын

Thank you so much for this!

@essamhussain2570 7 жыл бұрын

Very spectacular Video, I really understand the entire mechanism, thanks a lot

@hebabazina7265 2 жыл бұрын

amazing explanation!

@riapop123 3 жыл бұрын

thankyou so much for this! i finally understood it after trying to get it for so long!! thank youu

@antoniogramscisslut 4 жыл бұрын

it's 2 am and i have a bio exam tomorrow and i love you greg

@Ur0pinionDoesntCount 8 жыл бұрын

this is the best way ive heard it explained! thank you

@SirCharles12357 6 жыл бұрын

Excellent job explaining this! Thanks

3 жыл бұрын

very good explanation! Please make more videos with pictures. You helped me a lot during studying! ❤️

@wetsponge9186 7 жыл бұрын

This video made it seem so simple thank you for the help! Great explanation!

@ideallyneal 6 жыл бұрын

Just wonderful. Thank you

@raeeskhan8623 6 жыл бұрын

Thank you so much very good explained and love your structure.👏🏻👏🏻👏🏻👏🏻

@keannapar 8 жыл бұрын

Very nicely done! Thanks!

@merryjm290 2 жыл бұрын

Thanks a lot , you've saved me 🙏

@surat8591 4 жыл бұрын

Life saving video!! Thank you sir!!

@idahei1171 5 жыл бұрын

What i dont Understand: Chlorid is Negative and hco3 as well so why do i have to Change?

@leahmorin619 5 жыл бұрын

I don't think he mentioned this in the video but NaCl is present in the plasma as this reaction takes place. So HCO3 is forced out of the RBC into the plasma and attaches to Na (from the NaCl compound) resulting in NaHCO3. The Cl (from the NaCl compound) then enters the RBC to maintain electric neutrality. Thats why this process is called the chloride shift because Cl is shifting back and forth from the plasma to the RBC. Hope that helps! :)

@shreelagnamishra7448 3 жыл бұрын

Electric balance would have been the same if HCO3 stayed in the RBC and Cl in NaCl. Why exchange?

@tarikrafiq1846 Жыл бұрын

thank you very nice, appreciated

@tonnikask 2 жыл бұрын

Lmao. Been so many years after the med school and never knew since when I actually had this idea in my mind that acidosis is due to the lactic acid.. thanks. Well spent 8 minutes 😬

@chandanbs8334 3 жыл бұрын

Great job bro , jst awesome explaination man 🤩🤩

@aqsashah5329 5 жыл бұрын

Great👍👍👍👍

@nikki-kq6ul 7 жыл бұрын

Perfect explanation. Really helpful.

@boostshow3692 9 ай бұрын

10\10 thnx for the additional informations❤

@alexismarquess9274 3 жыл бұрын

Amazing! Thank you so much, it finally makes sense

@EdithMorales84 6 жыл бұрын

spectacular explanation. Thank you

@bergziege5994 7 жыл бұрын

Thank you for the easy explanation, mademy med physiology exam a lot easier

@seanhusted2160 7 жыл бұрын

Can you comment on the difference between the hemoglobin buffer system vs the carbonic acid-bicarbonate buffer system?

@noorbhatty8643 3 жыл бұрын

Started breathing properly after this video

@nicoledearmas130 6 жыл бұрын

Great explanation. Thank You

@willk3775 7 жыл бұрын

That was fantastic!!!!!!!!!

@legs_11.82 4 жыл бұрын

After we get the C02 from the working tissue cell, and its pulled into the RBC, where do we get the h2o from to turn it into carbonic acid? - do we just 'suck' it in from the high concentration of h2o in the blood plasma ? Thanks for the video ! the rest made more sense then my text book !

@AnatomyOnDemand 4 жыл бұрын

Since the blood is a watery (aqueous) solution the water is always present and available for use in chemical reactions.

@antoinerobinson1723 8 жыл бұрын

Man that was sick!

@razazaidi8714 6 жыл бұрын

Why is deoxygenated Hb a better H+ buffer/proton acceptor than oxygenated Hb?

@bluehourcore 4 жыл бұрын

this was insanely helpful!! thank you sir

@Dtechiera21 4 жыл бұрын

Thank you for this lecture man!

@adityadharankar8841 5 жыл бұрын

H+ ion plus Haemoglobin gives Haemoglobinic acid.

@Maggie-cw8qf 4 жыл бұрын

very good

@cleyope3495 7 жыл бұрын

Great video!

@ivansantiago1568 2 жыл бұрын

sorry to be ask so this is mean that hemoglobin is not specificly bind the co2 but it actually made it to bind H+? so what does bind the HCO3 in RBC ?

@104lalremmawiihmar3 5 жыл бұрын

This video basically saved my life 😅😅 ty tysm♥️♥️

@kylemcmahon9028 10 жыл бұрын

This was very helpful, thank you.

@jonathanron3269 8 жыл бұрын

Excelent video, can you point out some references abou the rates, duration and energy costs of these processes?

@AnatomyOnDemand 8 жыл бұрын

+Jonathan Ron My favorite reference for human physiology is "Textbook of Medical Physiology" by Guyton & Hall. Also, CVphysiology.com is a great online resource. Specifically what rates and durations are you interested in?

@jonathanron3269 8 жыл бұрын

Thanks, I'm trying to estimate a general limit time for apnea. so I'm interested in the reaction rates ( how long) and the rate of increase of CO2 levels in the blood and lungs

@mrnulliustestikleezeeastee7365 7 жыл бұрын

CVphysiology is indeed a gem. You've provided a well-paced and lucid video as well. Good job.

@kiranj2900 6 жыл бұрын

So carbonic anhydrase has 2 roles? It catalyses the breakdown of h2co3 and also formation of it?

@sebasaad9019 5 жыл бұрын

yes

@balletpiano6523 8 жыл бұрын

Thank you! Great video! Totally understand this now! :)

@Keyvan100 5 жыл бұрын

this is fire flames thank you.

@reignsoftball45 7 жыл бұрын

thanks this was awesome

@crickte 6 жыл бұрын

so so so helpful. thank you!

@MrBears25 6 жыл бұрын

Is carbonic acid diffusion from the lymphatic system into the blood effective or does it happen at a fast rate? I saw somewhere where they said this happened very slowly.

@masumakhan7246 9 жыл бұрын

thanks very nice vedio

@karn7922 5 жыл бұрын

Thank you so much! So helpful!

@Jamieforeals 4 жыл бұрын

This was so helpful

@asmansour6308 6 жыл бұрын

very helpful!

@zaralee652 9 жыл бұрын

so when is carbaminohemoglobin formed?

@AnatomyOnDemand 9 жыл бұрын

Carbaminohemoglobin is formed when ever CO2 binds to hemoglobin. Carbaminohemoglobin is simply the fancy name for hemoglobin when CO2 is bound to it.

@zaralee652 9 жыл бұрын

thank you :)

@0nezahassan123 6 жыл бұрын

really helpful..thanks sir

@SiberianHuskyF1 9 жыл бұрын

Well put! It was a little unclear for me before this.

@abdualmageedalharbi6837 6 жыл бұрын

Thanks

@sarahgh4069 6 жыл бұрын

Thhhank you

@biochemistry7785 5 жыл бұрын

well !! but i have a doubt - what happens if bicarbonate is accumulated in RBC???????????????? is it burst??????

@prajwalchalukya2150 6 жыл бұрын

U r excellent

@Bubbles00 9 жыл бұрын

When you create carbonic acid you are lowering the pH of blood but when the H+ is absorbed by hemoglobin and bicarbonate is kicked out to the plasma does that increase the pH of the blood? I think this is where im stuck when trying to understand respiratory alkalosis or acidosis

@tracymumbi 9 жыл бұрын

I'll try and help you out... I only know of respiratory acidosis but it's the same concept. Carbon dioxide reacts with water in the blood plasma. This forms carbonic acid (h2co3). Then an enzyme called carbonic anhydrase causes the carbonic acid to dissociate into hydrogen ions(H+) and hydrogen carbonate ions(HCO3-). What causes the pH to decrease, is the H+ ions combining with haemoglobin. They compete win oxygen and because they have a higher affinity for haemoglobin than oxygen, they reduce oxygen transport. Which is why you have difficulty breathing, drowsiness etc is this what you were trying to understand?