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Chapters
0:00 Introduction
0:50 Types of Cardiomyopathy
2:09 Risk factor
2:44 symptoms
3:20 Treatment
Cardiomyopathy is a group of diseases that affect the heart muscle.[1] Early on there may be few or no symptoms.[1] As the disease worsens, shortness of breath, feeling tired, and swelling of the legs may occur, due to the onset of heart failure.[1] An irregular heart beat and fainting may occur.[1] Those affected are at an increased risk of sudden cardiac death.[2]
Types of cardiomyopathy include hypertrophic cardiomyopathy, dilated cardiomyopathy, restrictive cardiomyopathy, arrhythmogenic right ventricular dysplasia, and Takotsubo cardiomyopathy (broken heart syndrome).[3] In hypertrophic cardiomyopathy the heart muscle enlarges and thickens.[3] In dilated cardiomyopathy the ventricles enlarge and weaken.[3] In restrictive cardiomyopathy the ventricle stiffens.[3]
In many cases, the cause cannot be determined.[4] Hypertrophic cardiomyopathy is usually inherited, whereas dilated cardiomyopathy is inherited in about one third of cases.[4] Dilated cardiomyopathy may also result from alcohol, heavy metals, coronary artery disease, cocaine use, and viral infections.[4] Restrictive cardiomyopathy may be caused by amyloidosis, hemochromatosis, and some cancer treatments.[4] Broken heart syndrome is caused by extreme emotional or physical stress.[3]
Treatment depends on the type of cardiomyopathy and the severity of symptoms.[5] Treatments may include lifestyle changes, medications, or surgery.[5] Surgery may include a ventricular assist device or heart transplant.[5] In 2015 cardiomyopathy and myocarditis affected 2.5 million people.[6] Hypertrophic cardiomyopathy affects about 1 in 500 people while dilated cardiomyopathy affects 1 in 2,500.[3][8] They resulted in 354,000 deaths up from 294,000 in 1990.[7][9] Arrhythmogenic right ventricular dysplasia is more common in young people.[2] Symptoms of cardiomyopathies may include fatigue, swelling of the lower extremities and shortness of breath after exertion.[10] Additional symptoms of the condition may include arrhythmia, fainting, and dizziness.[10]
Causes
Cardiomyopathies are either confined to the heart or are part of a generalized systemic disorder, both often leading to cardiovascular death or progressive heart failure-related disability. Other diseases that cause heart muscle dysfunction are excluded, such as coronary artery disease, hypertension, or abnormalities of the heart valves.[11] Often, the underlying cause remains unknown, but in many cases the cause may be identifiable.[12] Alcoholism, for example, has been identified as a cause of dilated cardiomyopathy, as has drug toxicity, and certain infections (including Hepatitis C).[13][14][15] Untreated celiac disease can cause cardiomyopathies, which can completely reverse with a timely diagnosis.[16] In addition to acquired causes, molecular biology and genetics have given rise to the recognition of various genetic causes.[14][17]
A more clinical categorization of cardiomyopathy as 'hypertrophied', 'dilated', or 'restrictive',[18] has become difficult to maintain because some of the conditions could fulfill more than one of those three categories at any particular stage of their development.
The current American Heart Association (AHA) definition divides cardiomyopathies into primary, which affect the heart alone, and secondary, which are the result of illness affecting other parts of the body. These categories are further broken down into subgroups which incorporate new genetic and molecular biology knowledge.[19]