Meldonium function was too much interesting,,😍 Love u sir from Pakistan 🇵🇰 . You are my all time fvrt ❤🤲❤

Very clear and made easy to understand.... Thank you Sir.

Clear and right to the point explanation

Really amazing effort

God bless you! Thank you!

Thanku soo much for detail

Helpful (Y)

Thank you

dear doctor, thank you very much, i am single mother and have 3 children, my son is disabled and i have suffered with chronic pain all over for 14 yrs day and night and most days i want to die as i cant bear the pain, its exhausting after 14 years , i live in Uk where doctors dont reveal any knowledge to help me, i am so exhausted i have tried every thing from urine therapy to blood letting and everything in between, i have tried most things , and spent all my savings on natural medicines, i was told i have fibromialgia but i am not sure what this actually means or if its correct, i saw the netflix series diagnosis and the lady Angel, in episode one had the same symptoms, she was taken from USA to Italy and diagnosed with cpt2, maybe i have this, how can i get tested please i really cant spend the rest of my life like this please please please help me am so desparate please yours sincerely Priti

13:35 Meldonium blocks a key enzyme in the biosynthetic pathway of endogenous carnitine ==> reduced long chain fatty acids' transport across the mitochondrial membranes via the " carnitine shuttle " ==> impaired beta oxidation of long chain fatty acid in the mitochondrial matrix & ATP production . The rationale for using meldonium in sports' activities is to divert the body's metabolism & the energy production pathways during exercise from lipids towards carbohydrates ; with an ultimate increase in energy production for the same oxygen consumption . In aerobic conditions ; for every single acetyl coA molecule produced from glucose through glycolysis & pyruvate oxidative decarboxylation an energy equivalent of 6 ATP molecules is generated ; while in case of beta oxidation of fatty acids only 4 ATP molecules are generated for every single acetyl coA molecule with an overall subtraction of 2 high energy bonds consumed during the initial step of activation of the fatty acid to acyl coA . So glucose is a way energy efficient compared to fatty acids & less amount of oxygen is required to generate the vital energy needs of the body through glucose compared to fatty acids requiring higher oxygen consumption ! In a way or another ; that might explain the pathognomonic sign of ketosis , Kaussmaul breathing of rapid deep respiration OR hyperventilation when beta oxidation of fatty acids takes the upper hand . so a high carbohydrates' intake along with co administration of meldonium before exercise will generate more energy for the same amount of oxygen consumption . Lord knows best !