Clonidine - Mechanism of Action

Рет қаралды 46,505

Dr Matt & Dr Mike

3 жыл бұрын

In this video, Dr Matt explains the MoA and the uses for Clonidine.

Пікірлер: 59

@james2488 3 жыл бұрын

I take Clonidine for PTSD & seems to do alright. Just I notice if I stop taking it, my HR seems to go really high for a couple days. I know you can get rebound hypertension, just never thought it would make HR go ⬆️ Great video as always!

@kuujjuaq58 2 жыл бұрын

What's HR?!!

@james2488 2 жыл бұрын

@@kuujjuaq58 Heart rate.

@daxterfireball 2 жыл бұрын

Yes it does. This is because on prolonged use of clonidine, Alpha 2 receptor is actually down regulated (which means there's lesser synthesis of Alpha 2 receptor). So when you suddenly stop the drug, there's all this release of catecholamine (norepinephrine) which cannot be regulated by the now downregulated A2. Catecholamine acts on heart, stimulates it, increases HR

@zhenzhang1924 2 жыл бұрын

Oh my god , i love you 😍😍😍 i was struggling with pharmacology trying to understand this , thaaanks

@DrewAlexandros 3 жыл бұрын

Love your work dr matt!!

@shvonned.burkemsncrnpagpcn619 7 ай бұрын

This was really awesome! Thanks Dr. Matt!

@Sealmeal Жыл бұрын

Amazing breakdown. This makes sense.

@taylorwilkey97 Жыл бұрын

Thank you! Clonidine works amazing for my Flushing of the cheeks I have social anxiety and anxiety in general and I can say without this medication there would be no way I would be able to function or go out in public! Work is a struggle and always will be I will sadly always fight flushing at a workplace job It requires stimulation at someone else’s pace. Which doesn’t work well for me physically or mentally or my blood pressure shoots thru the roof and I’m a red blushed/flushed tomato. Horrible stupid problem I wish upon no one.

@Mixed.messages Жыл бұрын

I’m interested how much you take for a mild anxiety disorder?

@taylorwilkey97 Жыл бұрын

@@Mixed.messages My Doctor and I settle on 0.3MG. 2x a day. I think the perfect dose is .2MG If it always to much split the pill in two. So now you have an extra MG on hand in case you need it. You might experience some feelings of being lethargic they’ll pass quickly as soon as you adjust to the medication.

@fonzarellyplay370 Жыл бұрын

It makes me depressed and I feel like I need to sleep all day

@taylorwilkey97 Жыл бұрын

@@fonzarellyplay370 Lower your dose tell your doctor it makes you sleep all day and makes you depressed.. Maybe switch to Propranolol or wait for your body to build its tolerance to the medication so you’re not lethargic or drink caffeine with it to upregulate androgenic receptors. We have 264 Million people worldwide that are depressed. Learning to control your state of mind really helps with that.

@fonzarellyplay370 Жыл бұрын

@@taylorwilkey97 thanks. I asked if it needs to build up in your system but she told me it should work immediately. I will ask her anyway and tell her how I feel

@Kingboo1081 8 ай бұрын

I’ve taken this at 100mcg-200mcg for chronic insomnia for about 5 months and it rarely fails to put me to sleep. Not many sleep aids work for me and I’ve tried them all. I had some side effects for the first ~1 month, dry mouth, dry eyes, constipation, dizziness and tinnitus. They’ve mostly gone now.

@yogi9631 Жыл бұрын

Great video

@4dirt2racer0 Жыл бұрын

thanks for the vid man

@no725 2 ай бұрын

Thank you 🙏🏻

@fayhariri1569 3 жыл бұрын

Alsalam Excellent video Thanks Doctor 💐

@David-bh1rn 7 ай бұрын

It removed 80% of my opioid withdrawal symptoms and I was able to eat again

@jcbanbury 2 ай бұрын

Omg thats great, I will get some

@jcbanbury 2 ай бұрын

Just the physical symptoms right? Aching etc...

@David-bh1rn 2 ай бұрын

@@jcbanbury yeah physical symptoms

@kinghados 3 ай бұрын

@RahulKushwaha-so5si 3 жыл бұрын

Thanku sir ❤️

@kuujjuaq58 2 жыл бұрын

Drug withdrawal treatment, nicotine being one of them. Don't know about its efficacy with migraine sufferers. Depends on the knowledge of the clinicians. Depends then, on whom you ask.

@sciencenerd7639 3 жыл бұрын

Cool

@nesrinech3967 2 жыл бұрын

is this mechanism found in the central nervous system or the periphery ?

@Nutmegp Жыл бұрын

Both

@kinglll5604 9 ай бұрын

Is it dangerous to take mirtazapine and clonidine together?

@spiritualsocratesthegreat 29 күн бұрын

How long can I take clonidine before becoming dependent? Please help me!

@nenadcubric2663 3 ай бұрын

Which is better for Social Anxiety, Agitation, sleep problems, High Blood Preassure, Clonidine or Propranolol

@hamid_gold 2 сағат бұрын

بعد اگر جرات داشتی کلونیدین را قطع مصرف کن تا سندروم ترک عذابت بده

@dr.sameertandon1642 3 жыл бұрын

Low volume 😔😟☹🙁

@SigmaMan3000_ Жыл бұрын

I take 2 clonidine and a melatonin just to have a chance to fall asleep

@hamid_gold 2 сағат бұрын

ترک کلونیدین راحت نیست،سندروم قطع مصرف داره

@owensathsihadesilva8739 6 ай бұрын

My baby boy just 4 years and seems he Hyperactive .and doctor recomond Cloridine tble.im just fear to take it and she told me to take just month if he take this for month and if he stop taking this any issue..aperciate if anyone respond me im from Sri lanka.

@captainamerica9028 3 ай бұрын

I wouldn't give your son clonidine. It's a bad drug

@jadesong_music 3 ай бұрын

I would definitely try some herbs that are safe for children of his age and melatonin before I would try clonidine it seems like something for older people. I would get a second opinion. Also, just not having sugar and having a really calming bedtime routine listening to some music taking a hot bath not watching TV before bed. Good luck.

@sorianasor9730 Жыл бұрын

why is it be used to treat ADHD?

@defaultbrownie 11 ай бұрын

Sympathetic Nervous System over activation (too much nor-adrenaline in the brain). For adhd with dysfunctional anxiety/anger disorders

@robertkitchens6341 8 ай бұрын

Can this drug be used for anxiety my friend swears by it

@taylorwilkey97 8 ай бұрын

Yes, it’s great at taking away that butterfly feeling in your stomach and a fast heart beat. It also helps people that have quiver in their voice when they talk to speak smoothly.

@PassionLeavesATrace 7 ай бұрын

@@taylorwilkey97how does it help with adhd?

@taylorwilkey97 7 ай бұрын

@@PassionLeavesATrace By shutting off excess noradrenaline. Clonidine has a sedative effect so I believe it helps with a kids hyperactivity more than his attention deficit, it makes the body feel calm or lethargic and lazy. So you don’t feel the need to fidget and move around, etc. Which results in less hyperactivity. I’m not sure about the attention deficit part possibly when someone with ADHD doesn’t feel hyperactive/fidgety, they can concentrate, possibly?

@PassionLeavesATrace 7 ай бұрын

@@taylorwilkey97 Yeah that makes sense a calm mind can focus. I'm interested because I have tried propranolol and now hoping Clonidine will work better that it did. Thoughts?

@taylorwilkey97 7 ай бұрын

@@PassionLeavesATrace That’s funny you say that I was on Propranolol before Clonidine Propranolol sort of worked, but didn’t. Clonidine is amazing it definitely works better and in another way. That alpha agonist is a lifesaver way better than a beta blocker.

@bryanutility9609 Жыл бұрын

How does this help with adhd?

@connnnnnor 7 ай бұрын

clonidine decreases the amount of norepinephrine in the prefrontal cortex. this basically eases the amount of "traffic" in the regions of the brain that control working memory and attention, which improves cognition

@bryanutility9609 7 ай бұрын

@@connnnnnor thanks. I’ve been taking before bed. Seems to improve sleep & mood next day