Describes the physiology and potential treatment options of the SARS-CoV2 viral infection.
Пікірлер: 149
@unihanded4 жыл бұрын
Thank you! You are an excellent teacher-able to break down complex ideas into understandable portions.
@Ddub10833 жыл бұрын
This deserves an award or something. Great stuff. Its so simple yet I walked away feeling like I understood it all.
@fatemearzanforoosh24484 жыл бұрын
This video is perfect like other videos in this channel. Thanks a lot Dr. Klioze for sharing very worthwhile information combined with visually attractive animation with us.
@josephfriday26614 жыл бұрын
Most instructive video I've seen.
@edisonpayton79502 жыл бұрын
i guess im asking randomly but does anybody know a way to log back into an Instagram account..? I was stupid lost my password. I appreciate any tricks you can give me.
@alejandrofrancis55302 жыл бұрын
@Edison Payton Instablaster ;)
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@Alejandro Francis I really appreciate your reply. I found the site thru google and Im in the hacking process now. I see it takes a while so I will reply here later with my results.
@edisonpayton79502 жыл бұрын
@Alejandro Francis it did the trick and I now got access to my account again. Im so happy:D Thank you so much you really help me out!
@alejandrofrancis55302 жыл бұрын
@Edison Payton no problem =)
@a12bcdef4 жыл бұрын
Absolutely brilliant presentation and visualization. And in my opinion very accurate. Thanks
@GilbertoGenga4 жыл бұрын
Thumbs up, I have been reading tenths of scientific articles and could really appreciate the effort in making complex concepts understandable!
@idrissamorehouse57763 жыл бұрын
I love that those of us that want to be proactive can go searching for this high quality visual /auditory learning -im sitting following along making notes and copying the art so i can absorb it all into my mind temple -THANKS DOC!!
@SidharthMiddela3 жыл бұрын
This is brilliant. One of the best explanations I have seen....
@TheDarim4 жыл бұрын
For a layman like me it's a splendid source of information. Many thanks!.
@MK-ih6wp2 жыл бұрын
I watch nearly every YT video on 1.5 x speed or faster.... Except for yours! Too much excellent detail & mostly all brand new info for me. Thank you for these excellent lessons for us lay people!!!
@tea21644 жыл бұрын
Thank you so much for making and posting this video!!
@swapnilmane77144 жыл бұрын
You have really great information..... Thanks
@ranevc4 жыл бұрын
Great visual explanation
@LovelyWorldFressia4 жыл бұрын
Very clear and informative, thank you for making this video.
@cosimoruggiero38363 жыл бұрын
Grazie a voi. Merci a vous.
@nazmabegum92484 жыл бұрын
Many many thanks. This is Dr. Nazma from Bangladesh
@ChacUayabXoc3 жыл бұрын
Judging by the numbers this video is way too underrated. People get scared by long scientific names or formulas, but my belief is that it doesn't matter if you don't understand them. I have no knowledge of these advanced biochemistry topics, but you should watch the video anyways. Just by hearing these names, even if they pose no meaning to you yet you are forming the basis to fill them with meaning when the time comes. When you stumble across the topic again and suddenly you think "Oh, I heard that name before"
@mohammedal-hammadi50854 жыл бұрын
So great video really! Thank you so much!
@alfadog79534 жыл бұрын
Thanks for your work, is a great lesson! Thanks a Lot!
@pierrevillemaire-brooks42474 жыл бұрын
WHOAAT ?! … so few views and this short documentary is SOOOO much more meaningful than the current media fear propaganda. Thanks a lot for this in depth look at the current virology issue and i hope you have more to come when the research offers new results. Take care :-)
@ericulric2233 жыл бұрын
Wow, extremely clarifying on multiple fronts.
@drf139hotmailcom3 жыл бұрын
Thymine, Adenine, Guanine, Cytosine in DNA. Uracil in RNA. Thank you for the information Dr Klioze. Your videos are excellent
@crazeeborg3 жыл бұрын
The bacteriophage type shown in the beginning is the coolest looking viruse IMO. They look like some type of nanotechnology machine.
@adelaros3693 жыл бұрын
Excellent Graphics. Thak you.
@gregonelraquel10854 жыл бұрын
Thanks doc!
@poojitha52733 жыл бұрын
Well visualized and detailed content. Really interesting...
@mahmoudaldeeb4524 жыл бұрын
the best channel ever
@azimparandakh29523 жыл бұрын
GREAT! video I'm saying this after watching lots of videos on the topic of coronavirus and the associated diseases
@thuypham83472 жыл бұрын
It has been helpfull for me, thank a gifted doctor
@stevenklioze55414 жыл бұрын
Awesome video.
@alz123alz3 жыл бұрын
EXCELLENT! THANK YOU
@amensaseasan17794 жыл бұрын
ขอบคุณคะ
@christin55694 жыл бұрын
Exacellant sir....
@aydenfunk34264 жыл бұрын
Thank you so much you have explained covid 19 better than any news channel or any doctor on the news I needed this I have been looking up how exactly the virus attacks the body and i get the same answer it binds to the ace2 receptors but this actually goes in depth and actually explains it thoroughly so thank you!
@reecejames86604 жыл бұрын
An amazing explanation, sincerely. I love that this guy does a whole explanation on the word "chimera" and then drops smorgasbord like its common sense
@Ddub10833 жыл бұрын
I loved that too.
@slaozcelik37513 жыл бұрын
thank you
@adhipmitra4 жыл бұрын
Good video.
@oibal603 жыл бұрын
And this is why we need #Ivermectin
@emanalsubhan38394 жыл бұрын
Excellent
@bigaltheoriginal65794 жыл бұрын
thymidine not thiamine ( vit b1 ) ... this type of fundamental error gives me chills about the accuracy of what otherwise appears to be a most cogent lecture.. was the actual video proof read by people in the field
@howardhurtt66124 жыл бұрын
A strong video. I would like to link my pre-nursing students to it. For your next edit, please check your pronunciation of "cytosine".
@abejaamarilla49614 жыл бұрын
Excellent!! Can you help us to understand how ivermectin works? Y how ibuprofen works in the inflammation process?? Please.
@davebodily14193 жыл бұрын
Any hope for something like this that explains the difference between mRNA vaccines and more traditional ones? And thank you for the video, brilliantly done.
@DoctorKlioze3 жыл бұрын
Working on it. Hopefully in a week or two...
@aydenfunk34264 жыл бұрын
Also what app or software did you use to make this video because I am looking for an app that allows me to show diagrams like this one.
@DoctorKlioze4 жыл бұрын
3D-Studio Max
@oibal603 жыл бұрын
Sounds like the _replicase_ was made by Harbor Freight (not... ummm... reliable).
@steverubealcaba86644 жыл бұрын
There are other Coronoviruses that use that receptor as pathway into cell. On WebMD, it states only 4 coronovirus strains are pathogenic to humans (excluding SARS-CoV-2) Two of those use this pathway into cells. So half of all Coronoviruses known before 2020 used this receptor as a point of entry.
@ergodon3 жыл бұрын
Very instructive video with great animations. Just note that 'cytosine' is pronounced 'siteoscene' but it is mispronounced as 'sistoscene' in the video, otherwise a worthwhile video.
@wolfram774 жыл бұрын
Given an RNA, would ribosomes in out cells produce the proteins as in others animal/plant cells/bacteria? If RNA is like a program, i mean do all cell follow the same programming language?
@DoctorKlioze4 жыл бұрын
That's a great question! I would say absolutely yes. Indirectly, that is the basis of genetic recombination and technologies such as CAR-T (Chimeric Antigen Receptor T-cells). I would assume that as long as the RNA strand is positive-sense, our ribosomes should be able to read and translate it into a functional protein regardless of the species of origin. Interesting theory!!
@wolfram774 жыл бұрын
@@DoctorKlioze Is there only one possible way to interpret an RNA? Or is it because of evolution? (In computers there are multiple instruction sets, but Intel's became popular). I am a student in computer science. This video is very well explained, thanks.
@glyph2414 жыл бұрын
It🔨❣️
@alaa25812 жыл бұрын
I don't understand the role of Hemagglutinin esterase ,the protein found on the virus surface. I hope to answer me 🙂
@DoctorKlioze2 жыл бұрын
That' a great question! Hemagglutinin is a molecular structure on the surface of certain vial particles that helps with viral binding and entry into the host cell. In fact, it's the dominant target protein on various strains of influenza and is the antigenic protein used in the quadrivalent flu vaccine every year. Certain strains of coronavirus also possess hemagglutinin esterase on their surface and its role is uncertain as binding and cell entry is facilitated through the spike protein. However, SARS-CoV2 is not one of these subtypes as it does not carry the HE gene.
@iceboys74043 жыл бұрын
Sorry, one more correction - it's Adenosine, not Adensosine
@citra54314 жыл бұрын
I thought that it was the RNA polymerase that produces messenger RNA, not RNA transcriptase? Or are they both the same thing?
@DoctorKlioze4 жыл бұрын
You're right! Probably the more appropriate name. Also known as Transcriptase.
@christin55694 жыл бұрын
Sir plz Can you prepare the PDF ....Sir...
@beckchristian93223 жыл бұрын
So,could we take iron supplements to help oxygen in blood?
@Takudza3 жыл бұрын
Only if you have a deficiency to begin with. Taking extra when you already have enough won’t help you carry more oxygen. People with suspected anemia caused by iron deficiency can get a blood test to determine there iron and hemoglobin levels.
@crazeeborg3 жыл бұрын
Can u do a video about CRISPR case 9 gene editing?
@DoctorKlioze3 жыл бұрын
That is some great stuff! I keep expecting to hear some news about a CRISPR-Cas9 therapy for coronavirus but, at this point, I think we're going to obtain herd immunity before any such therapy is clinically available. Possibly an option for future seasonal outbreaks?!
@crazeeborg3 жыл бұрын
kzfaq.info/get/bejne/juCCgMaAlbbbZok.html Check out the above video to see how Dr. Jennifer Doudna is involved in eradication, detection and testing of COVD2/COVD19 using CRISPR cas9 😀
@DoctorKlioze3 жыл бұрын
@@crazeeborg I read Dr. Doudna's book "A Crack in Creation" last year. When the new coronavirus was discovered earlier this year, I immediately thought that CRISPR technology would be perfect for both detection and cure (since that's exactly how bacterium use CRISPR to defend themselves against bacteriophages/viruses). Love to hear it from the horses mouth! Exciting times!! Thanks for sharing.
@iceboys74043 жыл бұрын
Just a quick correction - it's not cystosine, it's cytosine.
@christofferd6473 жыл бұрын
Is this video about coronavirusses in general or the specifick virus that is causing the current covid-19 pandemic?
@corneliussianturi4764 жыл бұрын
at this rate where's CRISPER IS???
@DoctorKlioze4 жыл бұрын
Great question!! I was also thinking this would be a perfect application for this technology (just read "A Crack In Creation" a few months ago)!!
@razzdazzjazz923 жыл бұрын
It should be of note that many Coronaviruses, including SARS-CoV do possess RNA replicases with 3’-5’ exoribonuclease activity. Otherwise, great video.
@michaeljenniferbrabson62633 жыл бұрын
Cystocine?
@DoctorKlioze3 жыл бұрын
I know. I must not have slept well the night before I recorded that... Cytosine.
@beckchristian93223 жыл бұрын
Hello professor. My microbiology professor said that HIV is VERY deadly to the human genome because of its spikes. However, I cannot follow this, because all research leads to coronavirus. I need to know about spikes and how human immune system protect against virus with spikes. Thank you
@jadumonigogoi8454 жыл бұрын
It is very wondering how a new zoonotic disease ,If it is really zoonotic disease infect and survive the its new host i.e human species for more than 6 month ?
@annmorgana28483 жыл бұрын
you know you are on an academic focussed site when most of the commentaries are pronunciation corrections and minutiae clarifications!
@aviator10174 жыл бұрын
that was a bacterial phage
@josakes Жыл бұрын
For the viewer concerning the "nucleotides" at 6:12. Thiamine is not a nucleotide but vitamin B1. Furthermore adenosine is the name of the "nucleoside" and cytosine and guanine are the names for the "bases." This is relevant as the nomenclature for nucleic acids depends on the structure. For DNA the nucleotide is composed of a base, deoxyribose and 3' or 5' phosphate and the nucleoside is just the base and deoxyribose. Here's the nomenclature: Bases - adenine, guanine, cytosine, and thymine Nucleosides - adenosine, guanosine, cytidine, and deoxythymidine Nucleotides - adenylic acid, guanylic acid, cytidylic acid, and deoxythymidylic acid Reference: ISBN 978-0470-54784-7
@tuberculiosis3 жыл бұрын
8:16
@gargistarline13053 жыл бұрын
From where RNA came in Corona Virus 🤔🤔🤔
@otrotland53776 ай бұрын
hmm, what about pee and sweat
@LetsFixITJoe3 жыл бұрын
by the way its just physical distancing but defenetley not a social distancing ...thats something totally different it means cutting of all social interactions, which is totally wrong and a very alerting behavior ;) ...i´ve never socially distanced myself to my friends and business partners, only physically ;) ....so dont continuing saying this wrong describtion....its only a physical distancing ok ? thanks
@cigguard34083 жыл бұрын
Don't say we discuss your Jesse.
@bencyber85952 жыл бұрын
vaccine development begin from ..
@amensaseasan17794 жыл бұрын
พาหะ
@mikeallison90192 жыл бұрын
You are mispronouncing cytosine. You say, "sistoseen" rather than "sight o seen" which is correct.
@DoctorKlioze2 жыл бұрын
I know. A few people pointed that out a couple of weeks after i posted the video. It must have been a segment I recorded during a sleepless night at 3:00 am! Unfortunately, I can't correct it without taking the video down and reposting. Maybe I can add a subtitle explanation... Thanks!
@baltakur13283 жыл бұрын
What about killing virus with another virus that attacks coronavirus
@DoctorKlioze3 жыл бұрын
Interesting concept! Supposedly, their is such thing as a virophage that can attack another virus. Since neither one has the ability to reproduce without a host, I would assume the entire genome of the two viruses would be incorporated into the host cell. The invader would have to encode for a protein that would then destroy the original virus which would seem to reduce the chance of the virophage from propagating. I don't think I'm smart enough to work that all out (I also couldn't understand Bitcoin 5 years ago which is why I'm not retired :-o)
@IowaGrandpaTrain4 жыл бұрын
Useful video, but is it really a doctor speaking? He mispronounces cytosine (Sy - toe - seen), not sis-toe-seem. Perhaps he confuses the nucleic acid cyTOSine with the amino acid cySTine. Details matter.
@DoctorKlioze4 жыл бұрын
I do have MD after my name but I'm an interventional Radiologist. My father and brother (both dentists) tell me that's not a real doctor! Must have been tired the night I recorded that. Mea Culpa...
@markreddington41714 жыл бұрын
very clear explanations. just an observation: the infection process uses 99% of the cell's mechanisms - very complex compared to a virus, which is actually just a substance. thus, if we want to decipher the cause-effect relationship we will have to look at the mechanisms of the cell, why it fails. I will promote this clip to emphasize the false general, and non-academic, perception that a virus has its own intelligence - an idea induced by the media
@Oneman.oneboat3 жыл бұрын
Cytosine..... Not cystosine!
@DoctorKlioze3 жыл бұрын
I know. I must have dictated that @ 3:00 am one night. Probably half asleep. Mea Culpa...
@amandac92943 жыл бұрын
I want to know why 18 people disliked this video... must be Trump supporters who hate education.
@relinerebase90072 жыл бұрын
WHY ARE YOU SHOWING BACTERIAPHAGES AS VIRUS
@robertingles99803 жыл бұрын
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@tonitoni48073 жыл бұрын
The debonair archer indisputably crash because hygienic gully burn amidst a tenuous heart. longing, honorable example