My dad is in the hospital now fighting for his life with CJD. This video helped me understand what’s happening with my dad. However, I’m broken right now seeing that there is no cure. I can’t lose my dad.

My mother was just diagnosed today with CJD. She is in the final stage of this disease. Thank you for this video!

Prionic diseases are the most terrifying diseases... CJD, Kuru, and FFI, possibly others are most terrifying...

my grand pa died of this disease. He was a vegan and this video helped me understand what are the other causes

This and CWD (Chronic Wasting Disease) seem to be caused by the same issue. Even a single prion misfold can cause your entire nervous system to turn on you.

My psychologist died from this cruel disease. So did an ex partners father. Thank you for the video.

My grandma died from this when I was 10. It was like watching dementia in hyper speed. She was in a wheelchair within only a few months, and only a few months after that she became mute. It only took about nine months for the disease to kill her, and we could only watch as she lost more and more of herself.

It appears my sister has this. Can't get movement specialist appt. No sooner than late next month so technically undiagnosed. Watching her declining every week. Body and mind failing and helpless to stop it. I am mentally preparing for the worst. Heartbreaking. 😢Anyone else going thru this at this moment your not alone. I feel this too. Be strong.

I hope one day we can find a solution to this awful prion problem

Even though Anthony is not real, watching him suffer from CJD almost made me cry. I wish he is the best he can be living in heaven

Knew someone who died from this. He had arm weakness so he initially thought it was a stroke. But further testing confirmed it was CJD. He was gone within a month. RIP Jeff.

My close aunt sadly passed away from CJD. It was shocking to see how quickly it progressed and how quickly it debilitated her. After her passing, we got a call from the Ministry of Health stating that we had absolutely no choice but to cremate her, which neither we nor most importantly my late aunt wanted. After a lot of begging, they finally gave us the option to bury her as long as she was bolted into a certain metal box that they were going to bring and place her in following the funeral that was instructed to be completed the very next day. It was extremely difficult to plan and negotiate all this in literally an hour of her passing. She's definitely missed 😢

I don't know why I got so attached to the fictional character that is Anthony, but I felt really sad for him.

My dad was diagnoised with CJB on Nov 8th last year and he passed away on Feb 1st this year. Just 60 days and he was done. Miss him a lot. he was travelling to US to visit my brorther. He was all fine before boarding flight and that was the last conversation we had. 30 minutes before his landing in Chicago , he lost his memories and he doesn't even remember i existed.

My mother Kim Lockrey just passed away in Petrolia Ontario Canada on Monday September 04th 2023, we just got word from the special autopsy team that this is what she died of 😢 This is two people in my life time that I've watched fade away in The most brutal way, my mom's ex husband's brother Adam Cataldo died of this when I was like 10 or 11.

I see great potential here! Great video. A Kurzgesagt style of video and animation, clear and concise narration, good vulgarization. I would have liked to see extra sources, though! CJD is still a very nebulous topic, and medical opinions on specifics differ. Multiple sources and confronting these oppositions in a short and synthesized manner would greatly improve this. Very educational and enjoyable video. Keep them coming!

My dad died from this and he was only 48 😢

I like that "subjected to an mri" having had one, i can say its very apt!

Excellent video. Could you do Lewey Body dementia? My cousin has this and parkingsons. So heartbreaking.

I have a family friend who had a strange case recently. He woke up one morning and couldn’t feel half of his body, normally a sign of a severe stroke, but it ended up not being a stroke. He was hospitalized and shortly after fell into a Coma, since then he’s undergone every test you could possibly imagine, seen specialists, ect and for the life of them they could not figure out what was going on he came out of his coma for a bit but lost his ability to speak and walk,and shortly after fell back into a Coma. Finally, doctors came to a conclusion that he had spongiform encephalopathy and was going to die very soon. As far as I am aware he is still on Life Support to allow his direct family to see him before he goes. What an absolutely brutal disease.

Being in the UK we got to learn quite a bit about vCJD after BSE jumped the spiecse barrier.

I was informed by the NIHS, back in the 1980’s that some patients who received HGH from pituitary donors (like myself) were diagnosed with CJD due to contaminated storage of those glands. Unfortunately it was reported by a minute percentage of patients worldwide. Luckily I was not in that affected lot but it probably took them several years to pin it down.

I've had so many family members pass of the familial form (23 people spanning 7 generations). I haven't done the genetic testing yet, very nervous to learn of the answers and how that will not only impact my thoughts of the future but also how it may impact my health insurance. Some of my family had huge regrets when learning they carried the mutation and their insurance dropped them. I am so sorry to hear of everyone's loss and experiences in the comments.

Moja mama je umrla od ove uzasne bolesti. Bila je potpuno zdrava uvek, umrla je sa 67.godina nakon tačno mesec dana od dijagnostikovanja ove bolesti. Oslepela je 10dana u bolnici, bila je u pelenama. Bolest je stravicna. Na kraju je bila u nekoj vrsti kome, hranu je primala kroz nos, nije bila pokretna uopste. Na kraju je umrla bas kao u ovom videu od upale pluća. Svakoj osobi koja ovo prolazi sa bliskom osobom šaljem jedan zagrljaj ❤️

"If you enjoy this video,..." 💀

Really amazing video! It will help the Medical students more than thousands time read.

So i saw an article of a naturally occurring prion anti-body and it's found in four people and they were testing it in a lab with some other phages i hope they find a cure real soon 🔜 don't want to see anyone else suffer😢

00:32 🧠 Creutzfeldt-Jakob Disease (CJD) is a rare neurodegenerative disorder characterized by rapidly progressive dementia, myoclonus, and ataxia. 01:28 🧪 Prions, misfolded proteins, play a central role in CJD. They self-replicate and convert normal proteins into abnormal ones, leading to cell death and disease progression. 02:27 📊 CJD can be sporadic, familial, iatrogenic, or variant, with different causes and risk factors. Variant CJD is associated with Mad Cow Disease and can be transmitted through contaminated food. 03:52 🩺 Diagnosis of CJD involves EEG, MRI scans, lumbar puncture, and the detection of specific proteins in cerebrospinal fluid. Brain biopsies are rarely performed in living patients. 04:49 💊 Unfortunately, there is no cure for CJD, and most patients with the disease die within a year of symptom onset. Autopsy confirms the diagnosis after death. Harpa AI

My aunt might be diagnosed with CJD. I hope it isn’t this disease, but if the worse thing we fear, we will all do our best to let her last time here be the best.

My dad died of this at 56 but we saw symptoms 10 years earlier

In 2001 my Mom is 51 years old and starts to become weird and would argue with my family. We see a neurologist who diagnose my Mom as having CJD some time in 2007. I'll give you a timeline as i fall into the 1% group who did everything possible. 2002 medical retirement and no longer driving. 2003 staying at home acting weird. 2004 arguments at home 2005 Walking but leaning forward. Able to put on a seatbelt. Ability to ride a subway with me supervising. Fly to another country. Taking medication. 2006 Walking around at night pooping and peeing on the ground. Last time she said she loved me. 2007 More aggressive. Pooping and peeing on the ground. Yelling. Walking skills are not good. Currently using dippers 2008. Same thing but more issues. By late 2008 the first seizure happened and she hit her head on the dresser. No meds for this yet as we didn't know. 2009. She's sitting in a chair as her walking skills are bad. Her ability to swallow food is lost. Multiple chocking events. Feeding tube is placed. Her weight has decreased. 2010. Transitioned from sitting in a chair all day to being in bed but the ability to sit up. Her weight picks up thanks to strictly tube feeding. More seizures are happening. Her eyes are open and she's alert. 2011 Her weight gained back but still the same issues. 2012 Mom is stable but she's showing signs of Alzheimer's as we expected from the beginning. Spent 2 months in a nursing home due to pneumonia. Goes back home 2013 Mom is stable, alert with eyes open, unable to communicate verbally, or comprehend correctly whats going on. She can still laugh and give me a kiss on my check if i ask for it. 2014 Stable but the feeding tube routinely needs to get replaced. Seizure meds need to get bumped up to a higher amount. Lab work comes out fine. 2015 stable but we start to get more of a sleepyhead state. 2016 Stable but the progress downward is showing. Her weight is picking up. 2017 same as above. But now a care giver is brought in to assist. My father has open heart surgery and doing dialysis 2018 same as above but progressively showing a lack of alertness or reacting/flinching to a light 2019 hospital visit for uti 2020 In a sleepy state more often eyes closed. Sometimes wakes up with eyes open and goes to sleep. 2021 progress downward 2022 survivors covid +. We as a family agree to not replace the feeding tube if it falls out. After we replaced it May of 2022. 2023. Sleepy state with eys closed nearly all day. I can still get her to kiss my cheek if i let her lips touch it. May I transitioned to a night shift for work 2pm to 10:30pm resulting in no help from anyone to change her diaper. Yes it was all me picking her up out of bed putting her on a bedside kamode to clean her bottom. I took extra care to ensure she couldn't touch her feeding tube. October 2023 My dad has liver seriouses and ascites. As im changing my mom on Sunday night October 15 she starting leaning forward and the tube fell out. We agreed to not put the tube back. October 29 my Dad throws up dark colored stuff that looks like coffee beans. He goes to the ER well aware my Mom hasn't eaten in 14 days. October 29th 9pm Mom passes away and my Dad wasn't home. Very painful to see my Mom pass away. Despite the Alzheimer's/cjd she started crying at the end. After 20 years of caring for my Mom I had a lot of time to think about what would happen if she's gone. Every situation in my head. I never gave the funeral or burial any thoughts. That was difficult. It cost $30,000 to bury her including the ceremony service. Stressful coming up with money needed, arrangements, life, and everything else. Hopefully this brings some help to someone. Please make your home 911 compatible. You'll thank me later.

My dad had a patient with this disease and they had to burn all of the equipment that came in contact with it

I lost my twin sis to this she had prion which went bad she had fatal sporadic insomnia she did not sleep for 5 months

Can you prion disease be transmitted through working with cadavers? If your handling a cadaver brain and dont take the proper precautions in hand washing or not touching other surfaces

Amazing video for medical students

We just found out my brother has CJD I AM so heartbroken right now.

This animation is amazing

On point video for medicos!!

It’s strange that this got recommended to me after I listened to the Vcjd album

This. Needs. More. Views.

Best explanation ever

Thank you dear!

Prion disease is scary and very interesting at the Same Time.

My brother passed at 62 of this horrendous disease

My dad is in KIMS hospital ICU diagnosed with CJD Pneumonia is attacked😢

I liked the video I’m surprised your channel isn’t bigger

underrated video

My father is suffering from this problem & at that time he is not able to open his mouth for food.. he is permanently on the bed 😢

nice explanation

I found this by searching its name “vCJD” when I was looking for videos on the album from The Patients

اهلا لقد اصبت بهذا المرض منذ شهرين .حيت عضني قط وذهبت لاخذ لقاحات عديدة لعدها بعشرون يوم اصيب نصف جسدي بتقل وتنمل عملت اشعة مقطعية ولا يوجد جلطة تم بعدها بيومين في الليل احسست بشيء يهجم على جهازي العصبي افقدني النوم نهائيا تم احسست كان كتلة خلف راسي تتحرك مع تحريك راسي وتصيبني بقلق شديد لا يحتمل اصيح وامزق ملابسي من القلق والهلع اخذت ادوية نفسية للنوم ولاكن تلك الكتلة المشلولة في منطقة المخيخ لا زالت انهض في الصباح مشلولة وا قلقة جدا اصيح وابكي اصبحت لا استطيع مغادرة فراشي ولا اكل لان عند الاكل تسوء حالتي واثاب بالقلق وايضا اصلحت انسى كتيرا وفقدت الوزن انا حرفيا اختظر . لم اشخص بعد لان في بلدي المستشفيات بالواسطة . العن اليوم الدي اخذت فيه اللقاح انا اعيش الجحيم كل يوم كاني في كابوس ولاكن لا اصحى منه الا بموتي😢. وانا متاكدة بان اللقاحات فيها بريونات وان كل بروتين دخيل على الجسم يصبح بريون لان ليس له انزيمات تحلله ويلتسق بالدماغ مما يسبب كل هذ العذاب 😢 انا اسفة لانه رغم التطور التكنلوجي الا ان الطب لم يتطور بل الادوية واللقاحات هي من امرضتنا .

This is in my sister late husband families members had this happen to him. Deadly 🤢⚡ condition.

My mum just got diagnosed with this.

why are prions so difficult to "kill"? I read its because its stable but what makes them stable? Also i really wonder how spontaneous cjd can just form from no where? And how does eating it make it end up in your brain?

Thank you very much

Earlier I used to think that prion disease only occurs when cannabilism is practised or someone eats prion infected meat

What membrane proteins are specifically being misfolded?

Awesome stuff

My mother died at the age of 49yrs 10 months

Fantastic video! Odd question from a layperson, but could it be argued that Alzheimer’s Dementia could be considered a prional disease because of the self-replicating behaviours of Amyloid Beta and Tau Protein, or is the prional classification specific to malformed PrP variants?

Wait what about not being mobile gives you pneumonia???

I thankfully will never have this none of my surgeons had it

Well made

There's some silver lining though, a breakthrough has been made to extend the life of mice infected with with prion diseases similar to CJD. They now just have to figure out how to make this treatment work on humans.

New kurzgesagt just dropped

Do you have the script for this video

such a rare disease (1 in a million) yet everyone in the comments knows someone who has it....

Can’t you get this via cannibalism alao??

I had watched another video on the topic of fasting, they claimed that after three days of not eating food, your body will begin to eat the improperly folded proteins in your body that are cancerous or may cause it. I wonder if it would cure this as well, since the pathology of it is to cause your proteins to improperly fold similarly?

4:49 bro looks way too happy about it

New fear unlocked:prion diseases

So is CJD dementia but 100% uncurable

Amaazingggggggg explainationnnn❤

My dad have this disease at age of 52

Mi padre tiene esta enfermedad hay cura si o no

50K views to 90K views? Thats even more quick.

Never eat Crazed Cannibalistic Cattle, I always say

Life is so fragile

I just found.out there have been cases of this being spread by wholw blood transfusions Im not a doctor but I am a meat cutter-butcher and this scares the hell out of me. It use to be just the brain and spinal tissue we had to worry about but if its in whole blood its going be in other tissues.

Omg my dad's friend just died of this 😢

So just like caner but 100% more harder to live

THIS IS LIKE CHRONIC WASTING DISEASE WHICH HAPPEN IN DEAR

interesting 🤔

Lost my sister to nv cjd at 18 years old :(

Man..i been complaining of these symtoms for a out three weeks...its just got worse...

Maybe 1 day we can make it enzyme to fix it.

and here I thought rabies was the most terrifying disease 😧

Free

Rebellion who?, for who?

A most putrid of maladies

I ate a fresh spawn and im looking on how to cure my curo , hahahahaha

hillary clinton has similar symptoms.

Aot when they hear spinal fluid

Did I notice any abnormalities ?? Well yeah the whole thing look’s completely abnormal.

If you enjoyed the video.... 🤣🤣🤣🤣

Prion is pronounced "Pry-on" and NOT "Pre-on". Please fix your video.

5:12 NO I did not ENJOY this video as My dad passed away. A lot of people here are the patients or the families of patients who are watching this with tears in their eyes. So no I didn't enjoy and from next time change your script for such videos. And be aware of what you are posting and writing for such fatal or any diseases because no body and I mean NOBODY enjoyes these kind of videos not even medical students and not even pharmacists. Some people can watch it for information purpose but they also get sad seeing how fatal the diseases are. This is not the place or channel which can be ENJOYED, watched while eating chips or made fun of. I hope the creator can understand what I mean. Do change your script for next videos. Only the families that have seen the death of their loved ones can understand what pain I have gone through.

I came here cuz of Batman Arkham knight

It come from meat beef

tso this how u get familial fatal insomnia?? so scary