Cross-presentation of exogenous antigen (MHC cross-presentation by dendritic cells)

Рет қаралды 44,913

Animated biology With arpan

Күн бұрын

This video describes the mechanism of cross presentation by the dendritic cells and its consequence

Пікірлер: 67

@starparik 3 жыл бұрын

This is easily the most detailed yet easy to understand video on Antigen Cross Presentation on KZfaq. Great work!

@animatedbiologywitharpan 3 жыл бұрын

Please share among friends and help me to reach big audience

@adrijabanerjee-ek6hw Жыл бұрын

This is one of the best explanation for cross presentation. Crisp short and really helpful

@animatedbiologywitharpan Жыл бұрын

Please support my channel via super thanks. Your small contribution like 1$ means a lot for us. The super thanks option is present at the lower right corner of any video, a heart sign with $ in it.

@muhammadagilwijayafaradis831 3 жыл бұрын

thank you! Basic Immunology Abbas didn't cover this topic as crystal clear as yours

@animatedbiologywitharpan 3 жыл бұрын

Please share with your friends and help me to reach big audiance

@kaung6019 3 жыл бұрын

Thank you so much for your explanation! It helped me understand the topic well.

@animatedbiologywitharpan 3 жыл бұрын

Please share my channel link with your friends and help me to reach big audience

@shaqayeqrudd1003 4 жыл бұрын

Great clarification on cross-presentation !

@animatedbiologywitharpan 4 жыл бұрын

Shaqayeq Rudd please share among your friends and help me to reach big audience

@124deaper1 2 жыл бұрын

You helped me clear my confusion, thank you so much!!

@animatedbiologywitharpan 2 жыл бұрын

Please share my channel link with your friends and help me to reach big audience

@demah5524 2 жыл бұрын

Great clarification, thank you so much!!

@animatedbiologywitharpan 2 жыл бұрын

Please share my channel link with your friends and help me to reach big audience

@nadiahhameem4180 2 жыл бұрын

This video actually clarified some of my concerns, thank you!!

@animatedbiologywitharpan 2 жыл бұрын

Please share my channel link with your friends and help me to reach big audience

@thenicosystem8606 2 жыл бұрын

Amazing! maybe only some dendritic cells do cross presentation due to the higher chance of lysis. So it’s like a captain of a ship performing a highly dangerous maneuver. then after successful completion of maneuver(presenting antigen on MHC I), the dendritic cell “earns it’s stripes” and gets the license to present, like you mentioned in the video. Such a cool video. Thank you.

@animatedbiologywitharpan 2 жыл бұрын

Thanks a lot my friend

@abhipentyala9568 Жыл бұрын

Great presentation. Thank you

@animatedbiologywitharpan Жыл бұрын

please share with your friends

@rahulsharma00 2 жыл бұрын

At 6:58 you said CD8+ helper T cells , CD8+ cells aren't helper T cells they are cytotoxic T cells , in the slide you showed correct but pronounced it incorrectly.

@animatedbiologywitharpan 2 жыл бұрын

thanks for pointing that out...it was a slip of the tongue...i would be more careful.. Butt i hope the overall video was useful

@kichellet.2436 7 ай бұрын

so good! thank you so much!

@animatedbiologywitharpan 7 ай бұрын

Could you please help me by sharing my contents with your friends.

@aulia650 3 жыл бұрын

thanks ! this video help me a lot

@animatedbiologywitharpan 3 жыл бұрын

Please share my channel link with your friends

@aimenshelly2986 3 ай бұрын

Thank you.

@animatedbiologywitharpan 3 ай бұрын

Could you please help me by sharing my contents with your friends group/ college group. I put huge efforts in making these videos but unfortunately not a lot of people are watching this.

@karlafeeley8703 2 жыл бұрын

Thank you Arpan! I’ll show my classmates

@animatedbiologywitharpan 2 жыл бұрын

That sounds great....lots of love from India

@tineocamia3673 Жыл бұрын

Thank you so much! I am just wondering if there is any chance to have a copy of your power point presentation, sir? I hope you could also consider it. Your channel deserve millions of subscriber, swear!

@vithushikuganesan3811 2 жыл бұрын

Nice one and thank you for the knowledge😊

@animatedbiologywitharpan 2 жыл бұрын

Really glad to know it was useful. Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance

@Arvind2863 Жыл бұрын

I have a doubt, u said due to some actions there is breakdown of antigen that causes MHC 1 receptor to come out and cause cross presentation, but at last u said it is the IL-2 cells that cause the dendritic cell to start cross presentation. Which one is correctcorrect?

@pritammaitra4072 4 жыл бұрын

Great explanation

@animatedbiologywitharpan 4 жыл бұрын

pritam Maitra please share my channel link with your friends and help me to reach big audience

@pritammaitra4072 4 жыл бұрын

@@animatedbiologywitharpan sure👍

@sercanz 4 жыл бұрын

Thank you, it's quite understandable and helpful, but it would be better if the references were avaliable for further reading. :)

@animatedbiologywitharpan 4 жыл бұрын

Please sharee among your friends and help me to reach big audience

@animatedbiologywitharpan 4 жыл бұрын

All the info is taken from kuby immunology 7th ed

@kaustubhrege969 3 жыл бұрын

Thanks

@animatedbiologywitharpan 3 жыл бұрын

please share my channel link with your friends and help me to reach big audience

@samikshasahu4729 3 жыл бұрын

Thank you 😍

@animatedbiologywitharpan 3 жыл бұрын

kzfaq.info/love/4IpyopsGWSjaPACNTZLuqg please subscribe to my second channel as well

@animatedbiologywitharpan 3 жыл бұрын

Don't forget to check out all my playlist

@shifasaleem6697 3 жыл бұрын

Why not dendritic cells could directly load processed viral antigens to class I mhc for cd8 activation .Why follow this complex class II and then to present to classI? Kindly explain

@emmali8638 2 жыл бұрын

I think it's because cd8 can only bind to MHC I and not MHC II

@ExternusArmy 2 жыл бұрын

Two reasons: Peripheral tissue is generally exposed to viral antigens but cannot activate naïve T-cells found in lymph nodes because infected tissue is generally stuck in place without access to the draining lymph node. Since pathogens infect the body most commonly through permeable tissue which is often immobile (for example, epithelial cells in the lungs), the infected tissue can't present the viral antigen to naïve T cells that are in the lymph nodes. The second reason is that infected dendritic cells are often unable to present MHC-1 peptides due to viral immunoevasin activity which is preventing migration and MHC-1 presentation. The solution our immune system came up with is cross-presentation which is an exception to the general rule where MHC-1 ONLY detects cytoplasmic antigens. A cross-presenting dendritic cell will then phagocytose extracellular parts of dying/infected cells which contain the viral antigen and then pass this onto the MHC-1 presentation pathway and thus activate CD8 T-cells. Hope this helps, and feel free to correct anything.

@leelockie5513 4 жыл бұрын

good video

@animatedbiologywitharpan 4 жыл бұрын

Please share my channel link with your friends and help me to reach big audience

@paullovett4663 4 жыл бұрын

What is the purpose of presenting antigens to a cytotoxic T cell?

@animatedbiologywitharpan 4 жыл бұрын

kzfaq.info/get/bejne/m7V_a812q9nTlKM.html watch this video it would be clear

@animatedbiologywitharpan 4 жыл бұрын

Please share my link with your friends and help me to reach big audience

@kunaljain197 3 жыл бұрын

Why not dendritic cell is killed by cytotoxic t cell when cross presentation is done by it? Pls answer.

@animatedbiologywitharpan 3 жыл бұрын

That risk is always there

@kunaljain197 3 жыл бұрын

@@animatedbiologywitharpan thank u so much sir! I liked the way of explanation very much.👍

@HamzaAli-om6fl Жыл бұрын

From where did you study this topic?

@animatedbiologywitharpan Жыл бұрын

Kuby immunology 7th edition

@aj-uo3uh 2 жыл бұрын

I wonder if cross presentation is used to present cancer protein to the naive cd8 T cell waiting in the lymph nodes. A cancerous cell shows cancerous protein on mhc1. Somehow it needs to be presented to a naive cd8 T cell for the first time so that it can clone itself and come to the rescue.

@animatedbiologywitharpan 2 жыл бұрын

You are right my friend. I strongly suggest you read this article for better understanding www.sciencedirect.com/science/article/pii/S0923753419541461#:~:text=Cross%2Dpresentation%20of%20tumor%20antigens,used%20in%20this%20same%20way.

@animatedbiologywitharpan 2 жыл бұрын

Please follow my instagram page and facebook page. Please share my youtube channel link with your friends and help me to reach big audiance

@aj-uo3uh 2 жыл бұрын

@@animatedbiologywitharpan Thanks arpan! That article hits the nail on thead.

@Rishab1702 4 жыл бұрын

Whenever I think I am done with immunology something new always come more I learn more doubt's I get which makes me more confuse. Sometimes times I think I should stop trying to understand it and just mug up all. what do you think sir?

@animatedbiologywitharpan 4 жыл бұрын

Don’t mug up...,, every field biology is evolving and changing .... no need to mug up... just enjoy

@a.s9509 4 күн бұрын

kzfaq.info/get/bejne/l92dlqp4r6myfmQ.html Here I think you mistakenly said "CD8+ T helper cells." Am I right? Because there is only CD4+ cells that are helper T cells. Great video BTW. Thanks

@animatedbiologywitharpan 4 күн бұрын

that was a slip of the tongue