Curing Alzheimer's Disease is hard. But WE can do something..

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Күн бұрын

Since it's first discovery by Alois Alzheimer, numerous scientists tried to find a cure for Alzheimer's disease. However, finding an Alzheimer's disease cure is difficult. But why is that? And is there anything we can do to lower the risk of getting Alzheimer's disease? Let's talk about the science Alzheimer's disease!
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0:00-1:13 Discovery of Alzheimer's Disease
1:13-3:17 How does Alzheimer's Disease Work?
3:17-7:11 Why is it difficult to Treat Alzheimer's Disease?
7:11-11:27 Can WE prevent Alzheimer's Disease?
Over 50 million people suffer from Alzheimer's disease worldwide. Alzheimer's disease primarily affects the brain. In early stages of Alzheimer's disease, patients become forgetful. Later symptoms include anxiety or severe dementia. Alois Alzheimer discovered that the brains of Alzheimer's disease patients have lost many brain cells. Furthermore, he described amyloid plaques and neurofibrillary tangles. Amyloid plaques and neurofibrillary tangles are toxic to brain cells and, therefore, cause Alzheimer's disease.
For decades, many scientists tried to cure Alzheimer's disease. Finding sufficient treatments or cures for Alzheimer's disease is challenging as first plaques occur decades before the patient exhibits first symptoms. As a consequence, current clinical trials for Alzheimer's disease need to be conducted for years which is not feasible. In the future of Alzheimer's disease, biomarker will likely solve this issue.
Current treatmens for Alzheimer's disease include acetylcholinesterase inhibitors and NMDA receptor antagonists. A few weeks ago, the FDA approved aducanumab which is an antibody treatment against Alzheimer's disease.
Some of us have specific gene variations (APP, PS1, PS2) which cause Alzheimer's disease. But the majority of AD cases is impacted by our environment. Studies have shown that we can lower the risk of getting Alzheimer's disease by having low cholesterol levels and blood pressure. Aerobic exercise and mental training has also demonstrated a beneficial effect in preventing Alzheimer's disease (brain plasticity). Sleep is also crucial as it can activate glial cells which partially remove amyloid plaques. Let's hope that there will be a cure for Alzheimer's disease one day!
For your reading:
Sharma, Piyoosh, et al. "Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies." Progress in neurobiology 174 (2019): 53-89.
Novak, Petr, et al. "ADAMANT: a placebo-controlled randomized phase 2 study of AADvac1, an active immunotherapy against pathological tau in Alzheimer’s disease." Nature Aging 1.6 (2021): 521-534.
Images:
Some pictures were derived from Servier Medical Art by Servier. You can find over 3000 free medical images here: smart.servier.com/
Alzheimers disease brain by Hersenbank, CC BY-SA 3.0
Drama masks by By Yuvika Koul, CC BY-SA 3.0
Brain Cells by GerryShaw, CC-BY-SA 3.0
Music:
Title: Danse Morialta by Kevin MacLeod (CCA 4.0 )
Title: Bread (Prod. by Lukrembo) jazz type beat “marshmallow” / lukrembo
Title: Rudolph by Lukrembro / lukrembo
Title: Art of Silence by Uniq / uniqofficial
Title: Outside Visitors, The Illstrumentalist
Title: Biscuit by Lukrembo / lukrembo
Title: Way home by Tokyo Music Walker / user-356546060
Title: Parallel by Ross Budgen / @domitochannel (CCA 4.0 )
Title: Black heat by Ross Budgen / @domitochannel (CCA 4.0 )
Title: Punch Deck by promoted by BreakingCopyright: bit.ly/bkc-ethereal2 (CC BY 3.0)
Title: Helen 2 by Nikos Spiliotis, promoted by BreakingCopyright: bit.ly/b-helen-2
Title: Blue boi by Lakey Inspired, promoted by NCM, (CC BY-SA 3.0)
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About Clemens Steinek:
CLEMENS STEINEK is a PhD student/youtuber (LifeLabLearner) who is currently conducting stem cell research in Germany.

Пікірлер: 64

@fresanegra77 3 жыл бұрын

I, I who don't really fear a lot of things, I am very if not horribly terrified by alzheimer's disease since I heard of what it does to the brain. When it comes to brain diseases I... I simply get horrified by their effects. And if this is true and we can at least slow down a really significant amount of time or diagnose it early enough that it won't be much of a problem to treat it, or even better, CURE IT. I, I would finally rest in peace knowing that at least someone in the world won't suffer from this disease and I may finally stop crying when I remember this disease. With lots of love and hope, a really, really scared teenager with hopes in medicine.

@jefferywest3625 2 жыл бұрын

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@strangerthanfiction2790 Жыл бұрын

I too have been terrified by it when I was your age. And with that fear, I made changes to myself and learned how to be more disciplined in my sleeping patterns, eating habits, and training my brain consistently. I learned how to be ambidextrous by writing and doing tasks with my left hand. I started playing chess when I was a teenager, I consciously eat healthy foods, and I started running and joining marathons. Overtime it'll get less scary, I promise 😊

@fresanegra77 Жыл бұрын

@@strangerthanfiction2790 I can do all of that myself but sleep will forever be my number 1 enemy as I can't really control it sometimes, but I'm trying, and at least I'm sleeping before 12am now and not at 3am And funny, I too was practicing to be ambidextrous but I'm a little lazy hahah

@lukase8033 2 жыл бұрын

I have learned that complex movements are even better for Alzheimers prevention than typical aerobic exercise. Running or cycling is already very good, but it trains the brain much less than, for example, dancing. We forget all the time that the brain is mostly used to control the body and abstract thinking is more of a recent anomaly. If you want to train your brain, then performing complex new movements might be one of the best ways of doing so. If you can't move, then complex fast paced video games are also very good. I have read about benefits in spatial cognition, reaction time and visual perception. I don't know if there is any evidence that it can help preventing alzheimers, but it propably won't hurt and is fun.

@Sciencerely 2 жыл бұрын

These are some great additions! Thanks!

@jpr4747 11 ай бұрын

I remember my own grand mother and m'y father. Both suffered of Alzheimer ( not my mother). In the case of my grand mother, we didn't know much about Alzheimer and nothing was done. However she was able to identify myself till her death, used to act weirdly ( paying with ancient currency, but once able to go for a 20km walk till a garden she has had ...telling fake facts - as journalists do !) As concerns my father he was given drugs to prevent him from moving or "escaping" and it was horrific. Doctors only wanted to control him and destroyed his brain faster. The brain exercises were humiliating : they treated him as a young child whereas I used to make him read complex books analysing political questions ( he had been a politician and took great interest in), about History ( he was fond of), I let him do calculus ( I'm a maths teacher) and he acheved better than my sister. But I was the only one to do that. It happened 2 times at the hospital they gave him strong drugs and for the first time he was not able to recognize me. He left the hospital ( he repeated : please, let me go out of this place) and after a few Days, he became again able to identify me. But another time, they gave him strong drugs and he never more recognize me. It was horrible. He was able to feel the feelings. But I hate all these doctors who decided to accelerate and worthen the destruction of my father's brain. I don't trust them for anything. Liars. In maths, we only respect truth and confidence

@k.k9206 Жыл бұрын

I do train my brain; My working memory for the last 10 years. I have ADHD, without working memory training I can't focus at all. My attention has greatly improved and my ability to take in information has improved as well, however, I will say that my brains ability to process the newly gathered information hasn't been dramatically impacted, but overall it has been one of the best things I have ever done in my life.

@Bringiton513 3 жыл бұрын

Thank you for the service you're extending to us. I do train my brain a lot as my profession is mathematics and physics. Sleep is my problem and I don't know what to do about it short of taking medicine which I don't want.

@aaronthewhiz3160 Жыл бұрын

Well RIP years of research on Amyloid Plaques

@AlejandroFerrariMc 3 жыл бұрын

I always find your videos so informative and entertaining. I'll never forget your video about MS, it helped me understand a bit more my condition. :)

@Sciencerely 3 жыл бұрын

Oh, you've been around for a long time! I'm glad to hear that you enjoy my content, that really motivates me!

@hadenhelms9184 Жыл бұрын

Criminally under-rated channel

@KURENANI 2 жыл бұрын

Can you talk about the connection between linoleic acid and alzheimers/demantia

@DogKacique 3 жыл бұрын

Great video, that's a very underrated channel

@darktrennow4426 2 жыл бұрын

Dankeschön für das tolle Video

@Sciencerely 3 жыл бұрын

Are you already doing any mental trainings which might lower the risk of getting Alzheimer's disease? Let me know in the comment section!

@everluck35 3 жыл бұрын

I am programming now and then. I guess this keeps my brain up to date. Very good video.

@patrickboudreau3846 Жыл бұрын

Hey friend, you do a real good job and your subjects are very interesting !

@SuperTommox 3 жыл бұрын

Amazing video

@wowjack8944 2 жыл бұрын

Hey, i like the video, but the music that starts around 2:30 does not really fit the subject or what you are talking about. The happy upbeat music doesn't fit the tone of the way you are reading the script and the material you are adressing. I am not an expert or anything, but i think a more omminous or dark tone would have done better.

@debayanmandal8368 2 жыл бұрын

I really wish you get all the more attention you deserve.. It really pains me to see you working so hard for them all the time irrespective of the reception Keep up the good work Sir 💜💜

@jefferywest3625 2 жыл бұрын

@guidosillaste4297 Жыл бұрын

They sayed the same think about cancer as well and then it turned out it was curable and preventable. All you had to do was avoid corporate shit.

@Dave_of_Mordor Жыл бұрын

i thought cancer was something all humans will eventually have. if you die before getting cancer, it just means you were lucky this whole time. had you lived a little longer, you would've gotten it.

@guidosillaste4297 Жыл бұрын

@@Dave_of_Mordor We get cancer daily , but usualy our immune system cures it ,if it fails to cure it then it leaves a mark on our body in a form of tumor or a birthmark(skincancer) this we can then cure our selves by giving our body what it needs to cure it. We but more effort in to saying there is no cure then actually curing someone.

@Dave_of_Mordor Жыл бұрын

@@guidosillaste4297 that's interesting. i didn't know we get cancer on a daily basis.

@guidosillaste4297 Жыл бұрын

@@Dave_of_Mordor i did not know either untill i read papers and watched lots of medical advice from doctors. The birthmark being a cancer blew my mind since i taought it was natural ,sadly was not.

@LappingMaster 3 жыл бұрын

Good video 👍

@notrly9938 Жыл бұрын

4:04 Clinical trials on dental work? :D

@dram3711 Жыл бұрын

I love the way you talk about antivaxxers. Not full of vitriol but facts about the benefits that they are missing out on.

@vincenthong3252 Жыл бұрын

APP, PS1, PS2 genes? I've played with all of them

@angeladavies Жыл бұрын

Eat Mediterranean style and physically active also try to get adequate sleep thou i find women are burden with monotonous house chores. Education I realise is wonderful so thankyou for your educational videos.

@jmc8076 Жыл бұрын

Complex movements like dance are better esp if you’re new and learning. Same with language. There’s apps but not sure if good science behind them.

@nim280 3 жыл бұрын

Thanks for the brilliant information.. What I do for training my brain is playing chess every other day..and learn new languages..

@luismallozzi Жыл бұрын

I've read the book titled the end of Alzheimer's, it's a wonderful book. In there the authors explained how there are a likely cooperation between an inflammatory response caused by foods rich in gluten (which raises the permeability of the gut to whole proteins), seed oils which are inflammatory, insulin resistance in brain cells that causes neuron death by starvation, lack of nutrients and heavy metal toxicity. All those environmental factors are present in majority of people's lives nowadays. Based on that, I began to eat healthier: very low polyunsaturated fats, less than 30g of simple carbohydrates per day, high fiber, absolutely no fructose and no gluten. My test results are wonderful: 68 fasting glucose, 2.0 fasting insulin, TGO TGP and Gamma-GT around 15 to 20, c protein is very low. I feel better now than when I was 20 years younger, and my brain works better than as far I can remember. I don't know if I will develop Alzheimer's in the future (my father had it) but it's wonderful to live the present being able to really enjoy it.

@benji9107 2 жыл бұрын

I have insomnia and this scares me

@adamadiallo6773 Жыл бұрын

Chamomille tea helps to sleep!

@jmc8076 Жыл бұрын

@@adamadiallo6773 It’s a good tip but if you have insomnia you’ve prob done a lot of searching for ideas online ...at 2:00am when you can’t sleep. 😉

@oriane9314 Жыл бұрын

When you were talking about the vaccine, you said that there was no significant improvement. But you also said earlier that alzheimer's disease kills brain cells, so just because the plaques-things are destroyed, why should the brain cells suddenly be alive again? It makes no sense.