Which *Health Metrics* do you actually need to track? We tried to answer this in our latest call Sam Corcos of LevelsHealth Catch it here kzfaq.info/get/bejne/mNhgfdR_up65lqc.htmlsi=SYcbVf3iWSIrwLKz and let us know your thoughts

David you look amazingly young. I can see myself aging backwards at 62. I will get myself checked for my biological age a year from i started intermittent fasting. I am presently on a 72 hour fasting. I was on a meal a day for 2 months, back on 20/4 fasting/eating. I go to the gym daily and do strength exercises. I just started to do hot/cold/hot therapy . I see some of my loose fat disappear, I lost 38 pounds, 5:2, weight 114 pounds. I am off several medications, I am regular naturally; after suffering with constipation forever. I am on the Mediterranean lifestyle diet . I owe this all to you and other scientists, Doctors, on KZfaq. You have given me my life back, a much better one, THANK YOU

David Sinclair is a true hero for me, and have inspired me to live healthy

I never ever get tired of listening to Dr Sinclair. I have been listening to each and every podcast, interviews for the last two years and follow what he suggested for longevity as far as I can.. well saving coffee money for nmn and others 😊. Each time i learn something new and my determination grows. Though he might tell the same thing but each time i understand it better but to my advantage. Thank you for getting him for this interview and asking the right queries which we the viewers wanted to know. One great thing about you... you don't interrupt him after asking the question and let his answer flow without break.. And one thing you look as if you are in your late 30s actually.

Thanks for having on David Sinclair, this is awesome.

Sinclar, Aubrey de Grey, Bryan and all the other smart longevitists should create a conference group or 'parliament' and advance like an undefeatable super think-tank on the question of what really and actually forces the body to retain youthfulness

The thing to remember about screening tests, eg for certain cancers, is that there is an incidence of false positives. The idea behind ‘targeted’ screening is to minimise these, and so minimise unnecessary further tests such as biopsies with the possible complications.

A great straightforward interview with David Sinclair. Inspired me to start looking into Metforman, in addition to all the supplements that I already take for longevity

That was a great interview with a lot of topics.

Been watching this guy for a while. HE IS AGEING like everyone else.

I do take NAD, Tru Niagen, in fact it's sitting right here on my desk.....I remember when I started on it an few years go. I ran across my very large estate yard, at full speed.

Deserves more views. Ty for this and having David on 🎉

Love listening Dr Sinchiler , He is always wonderful to listen and watch, A hope for millions of people. Thank you so much.

ppl r dying from aging every moment ! tthkx for doing as fast as you can

any tips on how to make it to 35?

if you take something like public health into account, it becomes clear that it makes sense that not everybody can get health care in the sense that everything gets measured and checked, if the risk is very low. If you have limited resources as a society you have to properly allocate them. we humans get very self centered sometimes.

Love the research in this space, but there seems to be few resilts so far that give clear instructions to follow.

i just ordered the book! I'm so intrigued.

Nice interviews❤️ please go on following doc. Sinclair, he Is a great scientist ❤️

Thank you for making NMN illegal to purchase in the United States, David Sinclair.

David, can you please say once & for all, will you publish a SECond BOOK discussing recent life extending information.

Would love to see David s. Dave asprey, dr Humbert and Bryan Johnson in a discussion

It is very interesting to listen to David SInclair. However, his purpose seems to be to develop products to sell. As such, this shines a darkened light on whatever he is saying. This may be the American way, but it has to be taken into account when listening to his comments.

It is so interesting to listen David Sinclair. Amazing podcast, thank you!

Thank u, David Sinclair

I tried the 300 an scrip thing, before long I was broke as hell. My Doc was living large and well. He just loved, to see me, though ~!!

6 minutes in. Curing blindness !!! No followup question !!! When you say people eating well can live to be 95 do you mean people born this year or people who are already old? Consulting an Actuarial Life Table, a person aged 92 can expect to live to be 95.

Easy to declare that you’re going to live to be 120 years old. Time will tell. The expected lifespan for this epoch of history is around 100 years give or take. I am all for anything that will improve quality of life for sure!

very good and smart man! but the question is: when will you be able to really reverse aging, not just talking about it. for example, when will you be able you reset the epigynum information, "clean the scratches" ?

very smart questions by a very well prepared host

Hi Auren Hofman and Dr Sinclair thank you for your great work I'm big fan . very important question: is NAD booster boost tumer and cancer ? 😢 if someone has cancer or tumer . Or don't have . Go get check before getting NAD booster MNM ??? Thank you very much I'm waiting for your answers

I am following David's guidelines faithfully - for 1 month now - and am down 5kg.and feeling good at the age of 76. Sleeping better with appropriate exercise, IF and Metformin supplements. However, here in the Philippines the cost of NMN9000 ResV with added Resveratrol is PhP7,700 for 30 tablets which comes from Japan and is evidently a crippling cost. I will be running Courses on this soon at our resort in Bolinao, Pangasinan together with Team Building and Immunity Boosting but must find a more economic source of NMN before I can recommend this to our guests Can anyone advise, please?

David Sinclair you need to have an interview with Brian Johnson the "Blueprint" Inventor. You need to check every marker he has and compare your results! The True test of what you are talking about. Let the Data prove who is Right. ❤

I am thankful to Sinclair. I was taking too much niacinamide, and he pointed out in a video that it can impair collagen creation. That is exactly what was happening to me, and I was in very bad shape. I am now fully recovered, though some accelerated face aging does appear to be permanent. Nonetheless, I have to call him on his claims. Claims, in fact, that shift the burden of proof inappropriately, as he should know as a scientist. Still, I will play along. 2:05 So tell me how you are undoing DNA damage, and I don't mean methylation. He knows as well as I, there is no fixing DNA, short of Science Fiction. We accumulate DNA damage that is carried on to the next generation of cell and the next. This is caused because our DNA breaks 10,000 to 100,000 times in EACH cell EVERY day. Most of this is repaired correctly, a small fraction is not. These breaks are caused by ionizing radiation from the sun, outer space, radiation in the ground, radiation in your food (potassium and carbon mostly). It is also damaged by chemicals. And lastly, it is damaged by quantum tunneling as a function of body temperature. Heat is in quanta, and by chance a bunch of these quanta can bounce into the same area and act like it is a higher temperature. Just being a few degrees lower extends lives dramatically. This is the reason bowhead whales live 200+ years. And the same reason naked mole rats live very long for rats. The rats are effectively coldblooded. That is why they don't need hair. We can't just tweak stuff and get cold and hope to live longer. Our enzymes have a very tight temperature tolerance, which is why you feel terrible if you get too hot or too cold. When the enzymes stop working, essential processes are disrupted and you die. Some people do have a partial cheat. There is a gene variant that improves the odds of a good repair. But errors will still be made. Good levels of the right antioxidants can also decrease DNA damage events. But if it is fixed and fixed wrong, there is no repairing it. There is no rational hypothetical path to repairing it. We have 4 far-fetched fantasies: 1. Whole genome genetic modification. That is absurdly far-fetched. Genetic modification does not look for a problem and fix it. A specific change...sure...not any random thing that just happened to that cell. 2. Whole genome swap. You find some undamaged DNA, multiply it without errors a few trillion times, then have it transported to every cell where the original DNA in that cell is destroyed, and then this new DNA inserted. There are only about 100 things absurdly challenging about this like every tissue has a different selection of DNA that is activated, methylation must be right, so it knows how old you are supposed to be, transporting that much DNA, without it being damaged won't be easy. Can you actually dispose of the old DNA without killing the cell before the new stuff is inserted?... 3. Nanites who know what your DNA is supposed to look like enter each cell and make all the repairs. Maybe in 200 years. 4. Something enters the cell and if damage is found on anything that is active, the cell is destroyed. Other cells have telomere extended, so they can replace the cells, and lots of stem cells are introduced to help. The problem with this is that some cells are irreplaceable, like most neurons. And there is no guarantee a person could even endure this, as they could be replacing nearly all the cells. It would probably feel worse than bone cancer. They probably would have to induce coma for months while this was undergone, if possible. And there is a bunch of other stuff we accumulate. We accumulate Advanced Glycation End-products (AGEs) especially glucosepane. You can reduce the accumulation using some supplements reducing the creation, but diet must change dramatically to have a very low AGE diet. No pan-frying. No deep-frying. No "air frying." No roasting. No grilling. No broiling. No poaching eggs, only boiling or scrambling. Low fat. Very limited oil choices. Even olive oil is out. Most cold pressed seed oils are okay in moderation: flax, sunflower, chia seed, and sesame. Pistachio, and avocado are also good. No roasted oils. Never heated above boiling water. No BUTTER. Only unfermented cheeses: Mozerella, Ricotta, Cottage cheeses. Parmesan is the worst, but most fermented cheeses are high in AGEs. No roasted nuts, except pistachios. No roasted nut butters, which is virtually every kind unless you make it yourself. Many things blended at high speeds have high AGEs. If it is only carbohydrate or only protein or only fat, it is not an issue. You can make a smoothie that is almost entirely carbohydrate, and that is fine, just don't put in seeds, nuts, oils or protein powders and such. Some dressings are okay, others are more dubious. If it is acidic, it is probably okay. If it is "Low Fat," it is probably okay. Only "Low Fat" mayonnaise is okay. Any sauce made with lots of tomatoes is probably fine. Anything acidic is probably fine. Protein or oil can be stirred in; you just don't want to blend with a powerful machine. For meat, you want soups, stews, chilies, meat cooked in spaghetti sauce, or other tomato based sauce at fairly low temperatures. Steamed fish, fish or other meat boiled in just a little water. Various crock pot stuff. And no cheating, cooking meat in those unacceptable ways and then putting it in a stew or chili or whatever. Of course, most vegetables and grains are much lower in AGEs than meat, so they should take center stage a lot. Then there are other accumulations. Age spots are made of Lipofuscin. If you have age spots on your skin, you probably have them in your muscle, heart, brain, and other organs. The main problem with this one is just obstruction. Though, that can be a problem in the brain, especially. Speculatively, new accumulations may be minimized by HIIT exercise and supplements and other activities that promote mitochondria recycling (mitophagy). Some people inherited better mitochondria in the first place. Another thing that accumulates is amyloid. There are about 30 different kinds because different proteins can misfold. Once this starts, it can be next to impossible to stop. Though, some of the tech that has been applied to Alzheimer's may allow other amyloid to also be removed. We also have the accumulation of scar tissue. This quick fix repair solution is good short term, not so good long term. Scar tissue does not perform the functions of the organs it is in. The more of it you get, the less function those organs have. And there are likely many other substances that accumulate in the blood. This may be why plasmaphereses seems to have health benefits. None of this means people can't live for several centuries. But it does mean it will likely require organ replacement, whole body replacement, or head transplant. That will not be cheap. And it will likely be limited to a small percentage that can afford that. And whatever tissue is not replaced will eventually die, most likely. Even if they could print your exact neural pattern...would that be you or just a copy? There is another way. We can engineer future generations to age far slower. No one wants to talk about this option because we want to be the ones living very long or our children that are already born. But this is by far the most cost-effective method, and likely the only one that will allow everyone at least of that generation and in the future to share in the gift of a long healthy life.

So this is (metformin) ,so you should take it @ 67 yrs or more ? DR David Sinclair may you let me know ? What about Pure Creatine for rebuilding muscles as the results are not the same when doing weight training ? I love the knowledge & research, am all for antiaging ,you are amazing a true Luminary. M

wonderful video and Dr. David Sinclar ! thank you ! Brazil!

Living longer without becoming elderly is the goal.

I am quite curious, how about putting our bodies without air conditioning?

Handsome David… great man🎈

Thank you, David! Where can I find the “results of monkeys” please?

Any thoughts on the benefits of a Power Plate?? Good or Bad for Health??

I do Hyberbaric chamber ,a pure oxygen capsule in a professional clinic ,athletes use it ,excellent for recovery, clarity of our brain ,our cells turn around ,any joint pains etc .M

Invest in your health yes 🙌

Crafted by Viet York from Mollyverse 00:07 Aging is not inevitable and can be reversed. 03:13 Advancements in aging research are leading to the possibility of extended human longevity. 08:58 Doctors are now focusing on treating aging itself, starting early to prolong healthspan. 11:40 Monitoring biomarkers is key to staying ahead of disease. 17:20 Hormesis concept promotes intermittent stress for health benefits 20:05 NAD levels play a crucial role in aging and health 25:25 Starting preventive medications in your 30s is reasonable under doctor supervision. 28:03 Ensure the science and data are true before making health decisions. 33:25 Fasting and longevity 36:04 Life appreciation is not limited by lifespan 41:44 Encouraging more scientists to start companies and commercialize their discoveries 44:41 Prevention is key to reducing healthcare costs by detecting diseases early. 50:13 David Sinclair's second book is expected to release in 2024 with co-author Met LaPlante.

Auron Hoffman most of the meat studies are paid for by the meat industry as are dairy studies (also paid by dairy industry) and likewise the egg studies. Unsure how well researched you were for this interview.

I am not being shady okay? just the facts. Sinclair is losing bone and collagen on his face at a normal rate. He has jowling, diminishing of his facial fat pads, deep groves in his tear throughs, wrinkles (despite the make up, professional lighting and filters). He dyes his hair. I cannot see his “protocol” working on the outside. I hope it is working on the inside.

So can someone tell me the recipe that David is saying to give me long geverty I’m 74 would love to think I can get another 20 years

His age is starting to show

You need to have $$$$ to buy the supplements.

Really! Taking a few pills, sleeping 6 hours a night and eating one meal a day and I will live to 120. WOW!

Mental health important, stress. Pain suffering is coming like a train into you when you reach old age. Inevitable. Everybody close to you died, or is dying or very sick. Money problems. Most morbidly obese. Family, Parents, friends.

Excelent video

What use living in a room of 120.

David Sinclair The Brainiac Of Knowledge Is Power!

At least the filter Sinclair uses isn't so harsh in this video and looks more like he actually is, 54. If anti-aging technology is coming, and it seems pretty obvious now that it is, quickly, I'm sure he can look a youthful version of his actual age for awhile. After all, he's still only 54.

The man is a hero but with plastics in our blood, chemicals in our food, and smoke in our air, do you really think this generation will make it to retirement?

i love this guy...my hero :)

I've been taking NMN (1g) and trans-resveratrol (500mg) supplements for 6 months, and I've noticed increased hair loss. My hair is thinning, and my scalp is showing. If I stop taking these supplements, I notice that the hair fall halts. Has anyone experienced this? Any advice?

There is this dude, bryan johnson who's apparently reversing his age

I've seen mice on NAD compared to those of not. Big difference.

Pity NMN is so expensive in other countries

Why ? To live incarcerated in nursing homes. As a very young 70 year young human, paralyzed by radiation, I suffer incarceration in a nursing home that doesn’t permit travel outside the facility. I wish I had taken more risks and possibly avoided this incarceration.

Good interview

Wish this bloke would stop chipping in with something banal, while Dr. Sinclair is saying something interesting .

No mention of the Hayflick limit ~?

If you could grow gills then you could still breath with the increasing levels of humidity. Have the genetics dept. look into it.

You cant defeat death he forgot that here is accidentally death too not only the natural one by age...

Lets go David!!

The host looks a little like Luke Wilson, am I wrong?

I so want to believe what David is selling. Who wouldn't. What he's selling is attractive to just about everybody. But no human studies on his claims, and many of his peers are really backing off his theories

Exercise for your cells. Micro like Macro. Exercise your cells. They need it like you do!

Anyone else notice Dave's hairline is receding fast n Lake Mead?

Thanks for such an educational video Can anyone tell me where I can find more information about life extension?

7:51 - Would these age reset pills be available everywhere possible or just the USA at first ?

Our bodys are designed to last to 160 years. and in some countrys many people do live that long.

Why the hell would anyone want to live to 120 most people are ready to hang the gloves up by their 70s

be nice to live forever to stay same age 30 32

19:29

And David takes Metformin at night?

Edoardo replied: "I-Dophler 🤣🤣🤣🤣"

Cmon David, a coffee is $2 @ McDs . A CT scan is still $1000. That’s no coffee for @ year and 1 1/2

David you look great😉👍👍👍our retirement homes will be empty if all will get younger

David sounds tired☹️

Before people call someone a hero or smart, look at this guy's history and Harvard's.

The best is not arrive to those sad negligence nursing dead homes

When someone recommends people to see their doctors for so called "early detection" without deciphering between mainstream doctors who are controlled by Big Pharma, FDA, i.e. those pushing lethal therapies like Chemo, Radiation, etc versus non mainstream doctors, who are genuinely interested in getting patients wellI with natural means, like sound, using frequency machines, etc. I take their advise cautiously.

Resveratrol is getting a bad rap lately and I need to know the truth. Why did I have a very obvious, repeatable result from taking resveratrol?… I never expected any visible results from taking it but I began to see that it was indeed responsible for increased endurance in a strenuous “ yoga with weights” class during which we increased heart rate and worked our muscles to their limit. I tested it over and over again. I stopped taking resveratrol because of the negativity around it, but I also had to stop taking the class!

If we live to 120, we're probably going to live a lot longer than that. Hell, that will take me to 2100. My niece and nephew will be 90 years old, which is amusing to think about. The idea of generational gaps starts to become meaningless.

To live 150 0r 200 ;you need strong teeth but for that you have to eat a lot of meat.

If you're not stopping on its track arterial inflammation, Artherosclerosis. You're wide open for death, full incapacity Forget anti aging, you won't reach elder age.

Of course, lots of money helps.

The problem would be the overpopulation if everyone lived to 120..People will still be having children and others would live an extra 40-50 years and where would you put all those care homes and who would work there? Logistical nightmare..

I never liked grapes or wine to much sugar

Nobody can control agging... probably stay healthier all over the rest of life by considering those advices... what About genetic disease....

No question about doctor because you are doctor Patient said that metformin created constipation and weight loss upto 14kg last four years

Aquele rícino parece mamona que é venenoso. Em doses pequenas o óleo de rícino parece ser homeopático então.

With the demographic crisis that is already happening, we need people to stay healthy for ad long as possible. I am surprised that Elon Mask is against natural life extension as he is aware of demographic woes we are experiencing.

From Dr. Sinclair's appearance, he shows no signs of reversing aging. He looks 50ish in age.

He seems emotionally tired.

If age can be reset, then we are talking about the possibility of immortality?!