Acting as a prologue to Dead Rising 2, Chuck Greene flees Las Vegas with his daughter Katey after an outbreak occurs, his wife dying at some point during it. In need of fuel and looking to stock up on supplies, Chuck and Katey stop at the gas station in the small desert town of Still Creek. After giving Katey a dose of Zombrex, Chuck has a look around town after hearing an explosion. Hearing screams and gunfire, he looks outside to see a large plume of smoke over the containment zone further down the road. Then someone steals Chuck’s truck, leaving the two stranded, just as zombies begin to infest the town. They take shelter in the gas station and barricade the entrance. With Katey needing a shot of Zombrex very soon, Chuck searches Still Creek for the drug and a way out of town.
After traveling through the small town, Chuck then discovers a road block with an overturned ambulance, which has Zombrex inside. During his search for Zombrex, he overhears a broadcast from a dead soldier's radio, saying that a backup quarantine crew will arrive at Still Creek by 9 PM. Chuck finds a motorbike, which he determines can be repaired. Loading it up on a trash cart, He takes the motorbike back to the gas station. Chuck examines the motorbike and determines that he will need five parts to repair the bike. As he searches town for the bike parts, he finds a handful of survivors in need of assistance, including the local pawnshop owner, who offers to sell his wares when rescued, including a spare wheel. Chuck meets Jason Wong and Archie Eaton fending off zombies behind the Department Store, with Jason giving Chuck the handle bar he uses for a weapon. After collecting all five parts of the bike, he repairs the bike just in time to give his daughter a dose of Zombrex.
Immediately after giving his daughter Zombrex, he must fight a psychotic mechanic. As Chuck and his daughter begin to leave Still Creek, the military arrives. Chuck barely manages to escape town with his daughter as the military clean the town of undead.
As Chuck and his daughter are driving along the desert road, they come upon the stolen truck, and the thief dead in the driver's seat. Chuck collects their belongings and his motorcross jacket. He puts on the jacket, then gets back on the motorbike, and they ride away.