DeepMind solves protein folding

DeepMind solves protein folding | AlphaFold 2

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Күн бұрын

A quick video on the basics of DeepMind's AlphaFold 2 breakthrough. Please support this channel by checking out our sponsors:
- Vincero: vincerowatches.com/lex to get up to 25% off + free shipping
- Four Sigmatic: foursigmatic.com/lex and use code LexPod to get up to 60% off
References and good blogs, articles, videos:
[1] AlphaFold 2: deepmind.com/blog/article/alp...
[2] AlphaFold 1: deepmind.com/blog/article/Alp...
[3] AlphaFold 1 paper: www.nature.com/articles/s4158...
[4] CASP14 Results: www.predictioncenter.org/casp...
[20] AlphaFold 2 video from Yannic Kilcher: • DeepMind's AlphaFold 2...
[21] Science: www.sciencemag.org/news/2020/...
[22] Nature: www.nature.com/articles/d4158...
[23] Fortune: fortune.com/2020/11/30/deepmi...
OUTLINE:
0:00 - What happened?
1:03 - How big is this accomplishment?
4:39 - Proteins and amino acids
5:17 - Protein folding
8:26 - How AlphaFold 1 works
9:45 - How AlphaFold 2 works
12:09 - Why is this breakthrough important?
13:19 - Long-term future impact

Пікірлер: 820

@lexfridman 3 жыл бұрын

A quick video on the basics of DeepMind's AlphaFold 2 breakthrough. Here are the timestamps: 0:00 - What happened? 1:03 - How big is this accomplishment? 4:39 - Proteins and amino acids 5:17 - Protein folding 8:26 - How AlphaFold 1 works 9:45 - How AlphaFold 2 works 12:09 - Why is this breakthrough important? 13:19 - Long-term future impact Please support this channel by checking out our sponsors: - Vincero: vincerowatches.com/lex to get up to 25% off + free shipping - Four Sigmatic: foursigmatic.com/lex and use code LexPod to get up to 60% off

@suntouch3r 3 жыл бұрын

16:00 Quick shout out to sponsors

@firecogs 3 жыл бұрын

I was hoping you’d comment on this

@avengingme 3 жыл бұрын

You're freaking beautiful, Lex

@eliriekeberg7127 3 жыл бұрын

I am deeply skeptical about the generalizability of this. I hope I am wrong.

@genentropy 3 жыл бұрын

@@eliriekeberg7127 Obviously we haven't seen the paper yet, but the nature of competition makes it so that it's very likely this is generalizable.

@christopherdevers2836 3 жыл бұрын

To the question of, do we like these short videos? Absolutely, and you said that you really enjoy making them. Double positive. Keep up the amazing work Lex

@babydragon1637 3 жыл бұрын

*raises hand*🙋🏼✌🏻😁✅🟢🦾💯😋🌟😎🔥 i second this motion & share these thoughts

@humanoid9787 3 жыл бұрын

It'd be nice to see his face too tho

@hughwaller6789 2 жыл бұрын

Thanks Lex, love your stuff.

@jared0801 3 жыл бұрын

"Hopefully I'm not being too poetic" 😂 that's why we love you Lex

@SomeSortaPro 3 жыл бұрын

You inspire me in many ways lex. You alone have spawned a massive interest in deep learning and AI in me and I can’t thank you enough. I just wanted to chime in just in case you see this comment and let you know you continue to massively positively influence my life. I really appreciate the time and love you put in to the things you release to the internet and I do my best to reciprocate that in my own ways every day.

@DheerajBhaskar 3 жыл бұрын

I've started to despise his overly romantic side. This is distracting me and turning me off. I've started watching less of his content of late. Others like it, so it's likely a win

@ozafter1 3 жыл бұрын

@@DheerajBhaskar I mean he's very young, he's never been married, has no kids, is basically an adult child who's brilliant

@nateo7045 3 жыл бұрын

@ozafter1 So becoming a "real" adult has nothing to do with extreme understanding of themselves and the world around them, but better yet having kids and developing a jaded world view? Maybe I'm being unfair to your argument but life with or without kids or a wife is not any less of a life. Lex talks about heavily impactful things, life is weird, and no one likes a bore. He asks questions and entertains concepts that most people's egos would be far too afraid of even bringing up, no matter how trivial the sentiment itself might actually be. We see this a lot with Rogan too. This is why people enjoy their content to the extent they do. Rogan has kids and a wife by the way.

@ozafter1 3 жыл бұрын

@@nateo7045 i didn't say that. i don't think he has an extremely deep understanding of himself (except in terms of learning and discipline), other people, or society at large. he's comically naive on human relationships and business. but whatever, i love the guy and this podcast is nothing short of amazing to me.

@jaymkz3225 3 жыл бұрын

Big respect for you man, been following you since you only had 50k followers. You are such a great mixture of intelligence, wisdom, respect, dry humor, thoughtfulness, open-mindedness, and integrity. Hardly ever do you see a person climb to the highest heights of academia, science, athletics/martial arts, and personal development (and maintain their sense of humility I might add)....Cheers Lex, from a fellow engineer and martial arts enthusiast, I'm proud of you and I can't wait to see what 2021 has in store for you man

@indamountains7953 3 жыл бұрын

Only reason I’m here to emanate Lex

@savaloy666999 3 жыл бұрын

...what this guy said!

@KnightMirkoYo 3 жыл бұрын

And above all, look at his eyes any time he talks about love. He is one of the best humans alive today. I really wish we could make him a president of the world.

@Dylan-hh7vo 3 жыл бұрын

Would love more of these mini-lecture episodes. Great work Lex

@KravMagoo 3 жыл бұрын

Yeah...now all he has to do is crank out a steady stream of these one-in-a-lifetime scientific advances and he'll get right on it!

@fenristhewolfslair3993 3 жыл бұрын

@metoo :)

@lodevermeulen9012 3 жыл бұрын

The moment I heard of this breakthrough, I was excited for the sure to come video of you explaining it. And you haven't disappointed me one bit! This was such a well structured and explained video and I love your personality that goes with the explaining (the occasional poetic or philosophical thoughts). Thank you so much for this video!

@henrugolf 3 жыл бұрын

This is such a huge accomplishment! Great video as always.

@betsyhamilton3591 3 жыл бұрын

Yes, please make more vids like this. Appreciate the concise, informative report.

@CyberKyle 3 жыл бұрын

Keep doing these Lex, they are so well done and explain a ton of good info in a reasonable amount of time! I love how the short term and long term implications are broken down nicely. I love the slide deck design too.

@michaelflynn6952 3 жыл бұрын

*dead serious monotone educational voice* "I'm just here to have some fun"

@bmoneybby 3 жыл бұрын

I've heard stronger emotional inflection at a Stephen Hawking lecture.

@ravenmoore3399 3 жыл бұрын

Im just here for the data lol

@spacebaby1174 3 жыл бұрын

reminds me of Charlie Rose from the 80s,,and i love it,,its my ASMR

@sudoall 3 жыл бұрын

It's LEX .. he is not that monotone .. just microtonal..

@michaelflynn6952 3 жыл бұрын

@@sudoall i know lol but i am here to have some fun

@willcshapiro 3 жыл бұрын

Ever since I heard the announcement I was hoping to see you do a video about it. Thank you Lex!

@vg5028 3 жыл бұрын

Thanks Lex, I really enjoy this style of video. Please keep them coming!

@walidhasan9739 3 жыл бұрын

these short videos are great! I read the alphafold blog earlier, and now watching your video!

@antonioemmanuelerenda8140 3 жыл бұрын

@Lex Fridman Keep trying to scam people, fake Lex.

@leonardoandrevillaciscusto1872 3 жыл бұрын

Great video! quick and important content! very inspirational as always.

@emrazum 3 жыл бұрын

Love these mini-lectures. Your slides are next-level

@coolboriz 3 жыл бұрын

I love those short videos that touch on recent advancements in AI - more please. Would love more technical details.

@justtoleavecomments3755 3 жыл бұрын

Please make more of these! I bet a lot of your viewers, like me, are undergrads in compsci. Seeing where our degrees could take us and how the skillset we're learning can be applied in a byte-sized video, that can be watched while on the toilet in the morning is great.

@GuyNamedZack 3 жыл бұрын

Lex this is one of the best videos I've seen on your channel! As a current BME student this was immensely helpful to my understanding - thank you!

@antonioemmanuelerenda8140 3 жыл бұрын

@Lex Fridman Keep trying to scam people, fake Lex. Hmm yes, I’ll use this as copy-paste.

@prasadchaturvedula 3 жыл бұрын

Your videos are very very informative and teach concepts that matter(to me at least). Grateful for your time and effort. Keep dishing out more!!

@zacharyrolandlittle 3 жыл бұрын

Please keep making quick videos like this talking about topics you find fascinating

@antonioemmanuelerenda8140 3 жыл бұрын

@Lex Fridman stfu fake Lex

@imranq9241 3 жыл бұрын

Please make more of these videos! this format is easy to digest esp

@pieterstofberg3841 3 жыл бұрын

Halfway through the video... so far I have not understood one word of what is going on. Kind of happy about that and VERY glad that there are people like you around that can keep an eye on this stuff.

@djohnjimmy 3 жыл бұрын

These short videos are fun for us too. Thank you Lex for teaching us in a way we can easily understand.

@MrJack8782 3 жыл бұрын

Thanks for this break down Lex, super interesting

@mattbordi 3 жыл бұрын

great summary of the new breakthrough. I think more of these shorter videos would do well, I enjoy them

@dmitriy7861 3 жыл бұрын

Damn, what a time to be alive! Also, huge thanks to you Lex, for all the work you do and such videos especially. I was just thinking about learning more about AlphaFold and protein folding in general when I read the news.

@KS-np4us 3 жыл бұрын

That is really inspiring, the progress we see in all subjects of science is far beyond my expectations. Thanks Lex for giving this insight

3 жыл бұрын

Wow that's exactly the AlphaFold coverage I needed!! Thank you so much Lex, you are a beast!

@dinoanastasopoulos8511 2 жыл бұрын

A Lex Fridman video on AlphaFold2 was not what I expected but definitely what I needed. Thank you for everything you do!

@pascualcme 3 жыл бұрын

This is super helpful Lex, please keep these videos up! Thanks!

@WestchesterNYMilton 10 ай бұрын

I just spotted this video. Lex! Yes, by all means, please keep on creating these educational lecture segments. You have a terrific way of breaking these complex lessons down to be understandable and fun to analyze.

@rafalborkowski 3 жыл бұрын

Great video Lex, this format is fun and really digestible.

@keitho9508 3 жыл бұрын

Thanks Lex. Groundbreaking development explained in groundbreaking video. You're honest, passionate and we trust you. Thanks a lot.

@twokidsmovies 3 жыл бұрын

Great video as usual!

@JorgeRamos-xw6dy 2 жыл бұрын

Thanks for the summary. Very cool, quick and concise.

@fahdhussein6760 2 жыл бұрын

This was a good roundup. Great new video with Demis too... keep em coming

@rafaelcamargossantos 3 жыл бұрын

Please keep doing this type of videos! Very informative and fun!!!

@theMidsizeLebowski 3 жыл бұрын

Thank you for highlighting this breakthrough Lex! I would not have realized that something so incredible had been discovered and how much potential a discovery like this holds unless an expert like you had called attention to it, thank you!

@frankdavidson644 3 жыл бұрын

Amazing accomplishment 👏. Unbelievable, Bless you all working on this 🙏

@Barneyismyname 3 жыл бұрын

Love these kinds of videos Lex, keep them coming please!

@xurofthenine 3 жыл бұрын

Beyond the monotone voice you can hear his enthusiasm. Just hearing how excited he is to talk about this makes me excited to hear about it. Love beyond bounds for Lex!

@algorithminc.8850 3 жыл бұрын

Great video ... clear ... great topic ... and the correct message: "try to learn something new every day ..."

@fcorp9755 3 жыл бұрын

This quick videos are great, please keep making them.

@lucha6262 3 жыл бұрын

“Inspiring beyond words” that’s right!

@milton420Go 3 жыл бұрын

Thank you for this video. Really nice work. Definitely would love to see more of such kind of short educational videos.

@antonioemmanuelerenda8140 3 жыл бұрын

@Lex Fridman Keep trying to scam people, fake Lex.

@entropica 3 жыл бұрын

Lex, don't dare to ever stop making videos like this!

@thomastracy5090 3 жыл бұрын

Thank you. Wonderful and timely. Your podcast has provided great content, especially during the necessary social distancing of this year.

@antonioemmanuelerenda8140 3 жыл бұрын

@Lex Fridman Keep trying to scam people, fake Lex.

@squeezy7252 3 жыл бұрын

Love the quick videos, please make more!

@ChowmutLe 3 жыл бұрын

Man what a time to be alive.

@tmillcon 3 жыл бұрын

Great video Lex! Keep them coming.

@jonathanchavez9203 3 жыл бұрын

This kind of videos are amazing. Keep it up Lex!

@ianbloom4934 3 жыл бұрын

This video is a great overview. I hope to see your coverage when the paper comes out. Thank you.

@91JoshB 3 жыл бұрын

Thank you for everything you do Lex!

@StKrane Жыл бұрын

Thank you so much for this video! I'm late to this fascinating and moving party that is your channel. It's growing on me very rapidly, though!

@user-or7ji5hv8y 3 жыл бұрын

this is a great summary. thank you

@ottolehto 3 жыл бұрын

These videos are great! Helpful and compact. Keep 'em coming! :)

@cam41527 3 жыл бұрын

I love the quick video format lex! Perfect to squeeze in before work 😃

@antonioemmanuelerenda8140 3 жыл бұрын

@Lex Fridman Keep trying to scam people, fake Lex.

@kundodamyth 3 жыл бұрын

Lex, I truly appreciate your work brother.

@umfmage 3 жыл бұрын

You would make the world's best professor. Super easy to understanding for dense material. A little dry humour to make sure you're paying attention.

@HunterLee11313 3 жыл бұрын

WOW! Thanks for bringing this to my attention.

@serconjonnington3542 3 жыл бұрын

Fantastic listening to you as always. Really nice news format. Thanks for you videos.

@KellenChase 3 жыл бұрын

Thank you for this quick summary

@rangv733 3 жыл бұрын

These short videos are definitely useful Lex

@joshtargo6834 3 жыл бұрын

glad you got this up so fast!

@antonioemmanuelerenda8140 3 жыл бұрын

@Lex Fridman Keep trying to scam people, fake Lex.

@joey1772 3 жыл бұрын

Thanks for the video Lex! I couldn't be more excited about this breakthrough. The profound implications for the future (years, not decades) of health really hit me in a deep way and make the AI revolution feel like it's well and truly underway.

@solarwind907 3 жыл бұрын

Really appreciate you sharing what you learn. Thank you very much!

@toddfoster77 3 жыл бұрын

Excellent summary insight. Thanks for a guide thru this most complex field.

@mtribe3442 3 жыл бұрын

Really impressive work by Lex in just a few days. I get a lot out of this and hope to see more regarding this breakthrough. Particularly I realized that I need to learn more about transformers. I'm not sure what it means but seems similar to the idea that has been on my mind for a while regarding the determination of relevant features...

@ninadesianti9587 3 жыл бұрын

Cool! Thank you for making this video. Make more videos like this please! It’s like reading an abstract of a paper. I appreciate the visualizations. If I can request, I want to see more animations.

@ChampionRunner 3 жыл бұрын

This I is what I was waiting for ❤️ thanks Lex , you are amazing. Waiting for your next video with self driving car model test and you playing a guitar. How do you manage all these things at same time is amazing. Keep rocking and keep hustling.🔥🔥🔥🔥

@Baronvonbadguy3 3 жыл бұрын

Great vid lex. Short and to the point.

@TimvonHahn 3 жыл бұрын

Great summary. I do hope you make more like this

@robv3872 3 жыл бұрын

you are the best thing to happen to youtube in years! Love the podcast!

@THeRealTroy07 3 жыл бұрын

Great Job! I particularly liked when you nerded-out at the end with the mind blowing awe-ness of encoded systems of proteins. Just like mathematics, computer language, and esoteric studies, Biology contains encoded information in plain sight. That 4 simple molecules in our DNA control all the diversity in Life as we see it and may be seemingly linked through gradual evolution, or even the daily process in an organism from their DNA through to every protien-fxn they need in a day/life/life cycle is computationally mind-blowing and YES ALPHA-FOLD WILL OPEN THE DOOR TO A NEW FUTURE. Whew, See i just nerded-out too.

@lornabath6609 3 жыл бұрын

Keep doing the videos Lex.. you are helping me to learn something new every single day..❤️❤️

@antonioemmanuelerenda8140 3 жыл бұрын

@Lex Fridman Keep trying to scam people, fake Lex.

@edisonsmith233 3 жыл бұрын

Thank you so much Lex. You have explained this extremely well thank you

@cadetcyuzuzo8219 3 жыл бұрын

Personally I'm very excited about this. Our boys at Deep Mind have done it again, this is a huge accomplishment.

@kevinhenry7958 3 жыл бұрын

Make more, these quick videos are Awesome.

@alimohammed2750 3 жыл бұрын

Enjoyable, great, and exciting videos, some of the best things the internet brought to us.

@luisalfonsohernandezpinamo3265 3 жыл бұрын

That was a great explanation of protein folding and alphafold2. Please make another video explaining alphafold2 once the paper releases

@gizgad567 3 жыл бұрын

Lex do more of these videos my man! Great work!

@Huffelisa 3 жыл бұрын

Thx for all the knowledge your spreading! Great video

@dirtrockground4543 3 жыл бұрын

Thanks for the breakdown, Lex. I've been excited to read about what is coming out of the AlphaFold news but your breakdown, as usual, is the most entertaining and informative.

@dirtrockground4543 3 жыл бұрын

White Ness Not really sure what you're trying to say. Seems like there was a good breakthrough and I was excited to learn about it. What do you want me to doubt? Doubt that the problem is solved? I don't have the expertise for that. Let's hear what those experts have to say. Doubt that the solution will fix anything? Again, don't have the expertise for that, but it looks promising. If you have doubt, then get to work and let us know your perspective.

@josephbrennan370 3 жыл бұрын

Very useful. Please make more!

@genoir-itsmusicart9169 3 жыл бұрын

Great video!! Please keep doing these type of video's. As an AI student at a university in the Netherlands it's great to keep up to date with reality in this way, thank you.

@ambujmittal6824 3 жыл бұрын

Next podcast idea: Interview with one of the team members of the AlphaFold project.

@tn15_ 3 жыл бұрын

That would be great if he could convince someone from Deepmind to come on

@tn15_ 3 жыл бұрын

@@aryangod2003 I didn't know that. Thanks!

@neslef3 3 жыл бұрын

@@tn15_ Ya it's too bad he could only get people like: Andrew Ng, Elon Musk, Stephen Wolfram, James Gosling, Francois Chollet, Richard Karp, Jack Dorsey, David Silver (who btw is a lead researcher at deepmind), Grant Sanderson, Daphne Koller, Donald Knuth, Noam Chomsky, Richard Dawkins, Garry Kasporav, Bjarne Stroustrup, Daniel Kahneman, Leonard Suskind, Jeff Atwood, Yoshua Bengio, Gilbert Strang, Michael l. Jordan, Richard Feynman, Alan Turing, Albert Einstein, and other "low tier" guests to come on. But in all seriousness, the quality of this podcast is really superb; the fact that he interviewed everyone on that list besides for the last three is really amazing.

@tn15_ 3 жыл бұрын

@@neslef3 I meant no slight to the quality of the podcast with my comment -- only that I was interested in hearing more from DeepMind and I figured Lex had the pull to get the interview. I only stumbled upon this channel 4 months ago, so I still have a lot of catching up to do! Also, I agree with you. The content on here is phenomenal and unlike much else on YT.

@neslef3 3 жыл бұрын

@@tn15_ Definitely didn't think you were saying anything bad about Lex, if anything thought maybe you just didn't know about him. I mostly just wanted to take the moment to list some of the incredible people he had on the podcast as he never ceases to amaze me with his guests!

@KaraNodrik 3 жыл бұрын

Thank you for being an educator, Lex

@lucickian0yoz 3 жыл бұрын

Thank you for this very nice presentation, Lex! Ted Chiang wrote a short story called "The evolution of human science" in which he tackled the idea of a future were AIs are so advanced scientists are rendered useless in the traditional sense. Won't give any spoilers, it's a very short one if you wanna search for it and read it. This AlphaFold achievement is huge!

@thewig70 3 жыл бұрын

Great work. Thank you for doing this Episode.

@colmtesticles 3 жыл бұрын

Great video Lex! More please!

@chun-weikong7086 3 жыл бұрын

Thank you Sir! It is quite an inspiring topic. Love your clear explanation!

@Kase_K 3 жыл бұрын

Very inspiring! Definitely going to spend some time today reading up on protein folding. Thanks for the lesson.

@Kase_K 3 жыл бұрын

@Lex Fridman You've been hacked lol

@arruhai 3 жыл бұрын

Now it makes sense. Thanks Lex.

@Macatho 3 жыл бұрын

Quite literally the definition of groundbreaking work.

@Bluesky-xo1vu 3 жыл бұрын

Yes, very helpful Lex, thank you!!!

@56phil020244 3 жыл бұрын

Fascinating video. Thank you.

@brennanrichards9086 3 жыл бұрын

Fantastic. Thank you Lex from the simulation 👍🏻

@Yoopless 3 жыл бұрын

Love this sort of content, Lex, please do more

@antonioemmanuelerenda8140 3 жыл бұрын

@Lex Fridman Keep trying to scam people, fake Lex.

@radus9190 3 жыл бұрын

Keep doing this kind of videos. They are amazing!

@antonioemmanuelerenda8140 3 жыл бұрын

@Lex Fridman Keep trying to scam people, fake Lex.

@dylanbrusstar6646 3 жыл бұрын

Dude, you’re smart. I just found your videos and love them. Ty