Derivation of Michaelis-Menten Equation

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Andrey K

Andrey K

9 жыл бұрын

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Пікірлер: 85
@imagineabout4153
@imagineabout4153 7 жыл бұрын
I hope you have a desk in some university, because i think you totally deserve one. More than my teacher for sure ahah
@dorothyotogbolu6485
@dorothyotogbolu6485 5 жыл бұрын
He's basically teaching the MCAT topics for free. this dude is amazing!
@animeandstuff5377
@animeandstuff5377 3 жыл бұрын
So Dorothy are u a doctor now I hope so lol
@dorothyotogbolu6485
@dorothyotogbolu6485 3 жыл бұрын
Anime and Stuff who are you? Soon though. I will definitely let you know.
@animeandstuff5377
@animeandstuff5377 3 жыл бұрын
@@dorothyotogbolu6485 lmao im an internet stranger who is studying biochem rn-and was wondering if you had become a doctor after seeing ur comment since u said ur studying MCAT which would mean if u did aight and didnt flop ur gpa prop in med school/gl to ya if ur not tho
@wem3121
@wem3121 7 жыл бұрын
That moment when you roam all websites and youtube channels to understand a specified information and literally none talk about it... then you find AK LECTURES simplifying your every doubt and question... seriously.. I'm really amazed. Thank you so much!
@mayamaya-ry3eg
@mayamaya-ry3eg 7 жыл бұрын
"and so what that meeeeans is.. " lmao i love this man
@egeugur8107
@egeugur8107 5 жыл бұрын
maya maya hahahahahaha
@bergamoteful
@bergamoteful 5 жыл бұрын
Andrey, you deserve a Nobel Peace Prize for your contribution to the knowledge of mankind ! You are very gifted a teacher ! When I graduate from med school, you might not be awarded yet but you will receive my donation!
@biased_
@biased_ 2 жыл бұрын
Can we take a moment to appreciate how this flawless explanation is made in one single take? 👏👏👏
@christinesarra3245
@christinesarra3245 4 жыл бұрын
You are totally good at what you're doing. You're making life with biochemistry bearable for some of us. Thank you so much!!!
@NieceyWeesey
@NieceyWeesey 8 жыл бұрын
Give this man an award!
@luljetegecaj8195
@luljetegecaj8195 5 жыл бұрын
Seriously he deserves it !!
@dagmfasil1001
@dagmfasil1001 8 жыл бұрын
Thank you for going above and beyond to make these concepts easier. But it would've been even more amazing if you had a link for your lecture notes.
@lesliemartinez2720
@lesliemartinez2720 5 жыл бұрын
Best videos out there. I’ve been watching theses since I took anatomy in high school!! Amazing
@kritirai4934
@kritirai4934 7 жыл бұрын
wow! your lectures are really helpful. what my teacher couldn't make me understand you make it crystal clear.
@nala9123
@nala9123 8 жыл бұрын
you are amazing in explaining and simplifying complex concepts Thank you so much
@dfballa22
@dfballa22 6 жыл бұрын
You got me through organic chemistry. Thank you so much!
@user-km8df4pe7x
@user-km8df4pe7x 5 жыл бұрын
Your explanation is so simple and logical. Thank you very much!
@deconteetardey848
@deconteetardey848 6 жыл бұрын
thanks so much professor AK Lectures you are such a blessing in my life.
@harshraj34512
@harshraj34512 6 жыл бұрын
I love your teaching style sir. Your channel really help me a lot. Thank you sir!!!
@JR41174
@JR41174 3 жыл бұрын
God bless your soul this is the best explanation I've seen so far.
@somebody0586
@somebody0586 7 жыл бұрын
God bless you andrey ... it is very clear and logic
@lilymoore3955
@lilymoore3955 8 жыл бұрын
Aah were have you been my whole life! great lecture. Thank you!
@C00ligdeSoBased
@C00ligdeSoBased 5 жыл бұрын
You are the GOAT! Clear, Concise, and well explained
@kisshorekumar4331
@kisshorekumar4331 3 жыл бұрын
CCWE!!
@yulemfany2067
@yulemfany2067 6 ай бұрын
Wow, So amazing, thank u AK lectures hope you deserve my rewards 🎉🎉🎉
@firaca100
@firaca100 4 жыл бұрын
You really has a very clear intonation and it helps me to understand as a non english speaker 😅
@janvithakkar3174
@janvithakkar3174 3 жыл бұрын
Best youtube channel ever.... thank you so much for the video !!!
@mary-janenjoku2107
@mary-janenjoku2107 3 жыл бұрын
You make biochemistry look so easy.. Kudos 👍
@sukanyahembrom6213
@sukanyahembrom6213 6 жыл бұрын
superb way of expalining .... it helped me a lot.................thanx for making such amazing lecture videos
@abcardico1654
@abcardico1654 9 жыл бұрын
Awesome lecture! Thank you:)
@Bannanakick
@Bannanakick 3 жыл бұрын
I really hope everyone seeing these videos is ackowledging the value of fee education. The quality is top
@quinxx12
@quinxx12 8 жыл бұрын
Why do I even go to my lectures! :D
@bothamira7407
@bothamira7407 4 жыл бұрын
same question to myself :)
@youzanetubeable
@youzanetubeable 6 жыл бұрын
Beautifully explained. Thank you
@francis2r
@francis2r 9 жыл бұрын
great explanations
@anjalishalajan7718
@anjalishalajan7718 4 жыл бұрын
Thanks for such a great lecture
@sportsport1654
@sportsport1654 5 жыл бұрын
Your videos are awesome. 💞
@ronlal652
@ronlal652 3 жыл бұрын
Great lecture,well presented
@TheGabXD
@TheGabXD 8 жыл бұрын
amazing video. thank you so much
@asmitapanthi7491
@asmitapanthi7491 6 жыл бұрын
u r amazing! Thank you so much
@manelminou1956
@manelminou1956 6 жыл бұрын
Hello, would you please help to understand the steady stand conditions where S0 is higher then this mentionned on the curve of Michaelis (initial substrate concentration is small)
@prestonnyanamah1574
@prestonnyanamah1574 6 жыл бұрын
You are just excellent!
@shangaahmed1991
@shangaahmed1991 5 жыл бұрын
you are the best person i know
@gianlucamodenese2574
@gianlucamodenese2574 6 жыл бұрын
Congratulations from your pronunciation, easy to understand for an italian like me :)
@drmksu38
@drmksu38 5 жыл бұрын
you are a great man .. your explain is amazingly better than my professor 👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻👏🏻thank you very much .. you save my life🤣🤣🤣🤣🤣🤣🤣
@Northleach11
@Northleach11 6 жыл бұрын
you are fantastic!
@ykl178
@ykl178 4 жыл бұрын
Amazing thank you
@crazyboy33398
@crazyboy33398 7 жыл бұрын
You are awesome.
@powerlinkers
@powerlinkers 6 жыл бұрын
thank you.
@ViktorLagunes
@ViktorLagunes 8 жыл бұрын
Excellent
@TheJajolt
@TheJajolt 3 жыл бұрын
"So can we derive such an equation, and the answer is yes." Fuckin' genius guy over here
@heenakhan9936
@heenakhan9936 5 жыл бұрын
Thank you sir
@Kenny-bk5rf
@Kenny-bk5rf 8 жыл бұрын
What is the problem with using regular rate law to explain the catalysis reaction? Can't we use experiments to determine the order of the reaction? Is it because enzymes are not considered reactants but their concentration actually changes the rate of reaction?
@lenorasalae.6913
@lenorasalae.6913 2 жыл бұрын
I love your lectures, they are quite comprehensible. could you kindly make your board much clearer. i can barely see what you explain
@ashlyntaylord9932
@ashlyntaylord9932 4 жыл бұрын
What’s equal at the equilibrium?
@shinyniha
@shinyniha 8 жыл бұрын
I have a question regarding steady state, how can enzyme-substrate complex remain constant if it increases throughout the graph? Thank you for your videos.
@nicolasnauli8658
@nicolasnauli8658 5 жыл бұрын
only the rate of reaction and the concentration of substrate increases throughout the graph. For the enzyme-substrate complex, its like work shifts in this certain analogy. You send someone to work at a place for an hour, then, when one hour has passed, that person leaves the place and you send someone else to go work at that place since that place is free, someone can take the spot to work. Two people can't work at that same place, but at the same time, if the place is empty then fill the job if you can. That way the number of people who work at that place stay constant (the concentration of people at that place stays constant), since only one person can be there at any time. If one person leaves, one enters, and the cycle goes forever...
@ashwitshetty9725
@ashwitshetty9725 6 жыл бұрын
what is the unit of Km constant ?
@irule11846
@irule11846 6 жыл бұрын
The mathematics makes complete sense but I'm a little confused with how you can assume a steady-state condition. To elaborate: this equation is derived assuming a very specific condition where K1 = K-1+K2. Of course, this is not the case everywhere. For example, if [S] >> [ES] >>>> [E]+[P], then, in my mind, it seems as though it's impossible for K1 = K-1+K2. In these initial conditions, for K1 to equal K-1+K2, you'd have to assume that the catalytic activity of the enzyme corresponds to the binding affinity of the substrate. This is not the case (is it?). Then using an equation we derived in these steady-state conditions, we somehow extrapolate the chemical behavior of these enzymes under other conditions! Like, how can we just assume that we can model enzymatic behavior at Vmax when the conditions are completely different in a situation where we can even begin to talk about Vmax? Any response is appreciated. I feel like I'm missing something fundamental here.
@sammmysam1291
@sammmysam1291 6 жыл бұрын
same...
@manelminou1956
@manelminou1956 6 жыл бұрын
so I
@MimicIsaac
@MimicIsaac 8 жыл бұрын
rate of enzyme = rate of rxn ... only if the reaction cannot occur without the enzyme. (otherwise there will be a basal reaction rate, and enzyme increases the rate of the reaction, and hence "enzyme rate" is a difference of those two). So, we're basically assuming that reaction doesn't occur without the catalysts. Am I understanding that right?
@MimicIsaac
@MimicIsaac 8 жыл бұрын
+MimicIsaac i think the answer to that question is, E+S is a new reaction entirely, and you can calculate enzyme rate by just studying that reaction ... without considering what happens when S -> products by itself.
@lawrencetrustmunyati6704
@lawrencetrustmunyati6704 2 ай бұрын
when you explained on the Km constant, you said its units are concentration but isnt that mathematically incorrect because the units cancel out?? at 15 mins.
@noorhoda4986
@noorhoda4986 Жыл бұрын
Guys did he made a video about co factors ?
@nicolas.leger3
@nicolas.leger3 4 жыл бұрын
really useful! #ChBE440Lectur8:MoreReactionMechanisms:EnzymKinetics
@BreezyBangladesh
@BreezyBangladesh 7 жыл бұрын
Greaaattttt
@yszhnd
@yszhnd 2 жыл бұрын
Why didn't i find you before. My exam is tomorrow and i know nothing of this😫
@ebenezernyarkoh465
@ebenezernyarkoh465 3 жыл бұрын
My worried is about the final Micheals equation .i.e equ8 and equ9
@emmanuelkiplangat2881
@emmanuelkiplangat2881 2 жыл бұрын
five years ago someone knew this
@Noorcm
@Noorcm 7 жыл бұрын
you sooo goood
@LoadyGvng
@LoadyGvng 9 жыл бұрын
Boinnnnnnng!!!!!!!!!!!!!!!!!!!!!!!!
@indahromawati7568
@indahromawati7568 2 жыл бұрын
Terjemahinin ke bahasa Indonesia dong
@APOLOnl
@APOLOnl 8 жыл бұрын
all i can hear is: equation equal to equation number equation equation substrate equation number equation.... omg i am failing so hard :' (
@NieceyWeesey
@NieceyWeesey 8 жыл бұрын
+APOLOnl LOOOOOOOOOOOOOOOOL
@APOLOnl
@APOLOnl 8 жыл бұрын
+Niecey Weesey hahaha luckily i still passed my test xD i love AK lectures. i was studying as a beast that day and got a little tired at that point xD
@NieceyWeesey
@NieceyWeesey 8 жыл бұрын
+APOLOnl Congratulations!
@amogelangsekhu3906
@amogelangsekhu3906 9 ай бұрын
come for me if you will. but this definitely was not the best explanation as most of these comments say.
@mohamednoormoalim9864
@mohamednoormoalim9864 7 жыл бұрын
the concept is clear but the writing is not clear to understand so the writing makes me boring so change and make writing clear.
@mominahussain5552
@mominahussain5552 7 жыл бұрын
The writing makes you boring? what
@hajiradurrani5730
@hajiradurrani5730 3 жыл бұрын
Wot
@omoyeniojoadekunle2919
@omoyeniojoadekunle2919 Жыл бұрын
This KZfaq channel is the best have ever seen in my life 🥲
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