Three leading scientists from The Florey are teaming up to tackle a harmful protein that builds up in patients with brain diseases.
The protein, known as TDP-43, accumulates in the central nervous system across a spectrum of neurodegenerative diseases including motor neurone disease (MND), frontotemporal dementia, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and chronic traumatic encephalopathy (CTE).
Removing TDP-43 shows promise for treating these diseases, but because the protein is located within brain cells, it is very hard for medications to reach.