Serological tests to diagnose Celiac disease are: IgA tTG plus serum Total IgA in order to ensure that the patient generates enough of this antibody to render the celiac disease test accurate. If IgA tTG came positive that will confirm CD If IgA tTG came negative and serum total IgA reduced, IgG tTG will be needed. If IgA tTG came negative with normal Total IgA then anti endomysial IgA will be needed also DGP and IgG tTG is recommended if there is deficiency in Total IgA that might caused by CD and might cause false positive results of IgA tTG or EMA IgA. One last important thing is that the patient must be on gluten diet for 6-8 weeks before performing tests. Also Biopsy and Genetic Testing of HLA DQ2 and DQ8 can be used if needed. Good Luck

@@wrenfan Not if all the symptoms are there and the risk of the testing out ways the benefit to the patient. Genetic testing should be sufficient if symptoms are present. Period. There are risks with sedation and the utter invasive procedure itself to the patient. I say use genetic testing and let the patients medical history and symptom expression dictate the treatment. A genetic diagnosis should be sufficient in my opinion.