"Anti-Amyloid & Anti-Infective Peptoid Mimics of LL-37"
Alzheimer’s dementia can be caused by (or at least, accompanied by) polymicrobial cerebral infections, a phenomenon receiving renewed attention given recent discoveries. The Barron lab is working to develop biostable peptoid mimics of LL-37 as therapeutics that can combat antibiotic-resistant infections, especially cerebral infections, which also bind to and block the fibril and plaque formation of Alzheimer’s-associated ABeta peptides.