PFAS are widely used, long-lasting chemicals that have caused widespread contamination in our air, water, and land. Compounds in PFAS are so strong that they don't degrade naturally and linger in the environment, earning them the label "forever chemicals." Studies have shown that PFAS exposure may be linked to harmful effects in humans and animals. In a panel at SXSW 2024, Leslie Hamilton, APL, and Mohamed Ateia Ibrahim EPA, discussed how government, academia and industry are working together to overcome PFAS-related challenges by developing new technologies, approaches, and policies to detect, destroy, and ultimately replace these chemicals.