Epigenetics| DNA methylation | Histone Modifications| Bisulfite sequencing| Genetics for beginners

Рет қаралды 68,254

Күн бұрын

This video lecture explains
1. What is epigenetics?
2. What are different factors and processes affecting epigenetics?
3. What is DNA methylation?
4. How DNA methylation regulates gene expression?
5. What is bisulfite sequencing?
6. What are histones?
7. What is histone modification?
8. How histone modification regulates gene expression?
9. What are the end points of epigenetics?
Image Credit: Wikipedia
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0:00 Epigenetics: Epi+ Genetics Literally means "above" or "on top of" genetics
3:01 DNA methylation, the addition of a methyl group, or a chemical cap, to part of the DNA molecule, which prevents certain genes from being expressed.
7:30 (Without histones, DNA would be too long to fit inside cells.) If histones squeeze DNA tightly, the DNA cannot be "read" by the cell. Modifications that relax the histones can make the DNA accessible to proteins that "read" genes.

Пікірлер: 69

@seema.sankeshwari Жыл бұрын

I feel like i have got my dronacharya to learn genetics... Sir thankyou so much sir . Keep uploading about genetics,, there's a list of genetic test and etc etc things listed in harvard online courses kindly explain those not everyone is affordable to learn there. Please sir please. And please explain about base editing expt undergoing in Japan for genetic disease treatment

@BiologyLectures Жыл бұрын

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@seema.sankeshwari Жыл бұрын

@@BiologyLectures yes daily am doing notes from your videos.. blessed to have such teacher.. thankyou sir thankyou so much🙏🙏🙏🙏🙏

@BiologyLectures Жыл бұрын

@@seema.sankeshwari you are most welcome.🙂

@jonahliealegre9130 2 жыл бұрын

Thank you so much for this very clear explanation. 💯

@BiologyLectures 2 жыл бұрын

you are most welcome. Wish you all the best

@mariaerasoaraucana25 Жыл бұрын

very clear and simple, thank you

@BiologyLectures Жыл бұрын

Thank you very much 😊

@jhomarbotin4909 15 күн бұрын

THANK YOU SO MUCH!

@lolitalool2830 2 жыл бұрын

thank you so much for this very useful and clear lecture💯

@BiologyLectures 2 жыл бұрын

You are most welcome. Please subscribe us to support us.

@gs35364 2 жыл бұрын

Thanks sir for making it understandable

@BiologyLectures 2 жыл бұрын

You are most welcome

@predator8210 3 жыл бұрын

Very good explanation!

@BiologyLectures 3 жыл бұрын

Thank you very much. Please like share and subscribe.

@investincrypto2859 Жыл бұрын

Excellent explanation. Keep rocking.

@BiologyLectures Жыл бұрын

Thank you, I will

@hlufe.e 2 жыл бұрын

Keep continue cover genetics at higher level

@BiologyLectures 2 жыл бұрын

We will certainly cover more topics on advanced topics. Please feel free to suggest some if you have any. Thank you.

@telugumusicalworld5606 3 жыл бұрын

Thank you

@BiologyLectures 3 жыл бұрын

You're very welcome! Please consider subscribing us. Thank you.

@sayunijay4742 Жыл бұрын

thankyou so much

@BiologyLectures Жыл бұрын

You are so welcome!

@Jillani984 Жыл бұрын

Very helpful Thank you sir

@BiologyLectures Жыл бұрын

You are most welcome.

@davidmansaray3563 3 жыл бұрын

Perfectly put!!!

@BiologyLectures 3 жыл бұрын

thank you.

@nishadhenwal7756 3 жыл бұрын

Thank you sir ❤️❤️❤️

@BiologyLectures 3 жыл бұрын

Most welcome

@hassanhijazi4757 2 жыл бұрын

One thing to add is that not only tails but also histone cores are modified.

@Jonathan-kl6zt Жыл бұрын

You should redo your lecture with better acoustics. And a bit slower

@simplysatisfying6572 Жыл бұрын

Very helpful lecture plz make more such videos 😍😍

@BiologyLectures Жыл бұрын

thank you. We will

@Hari788 3 жыл бұрын

Very well explained. Thanks a lot sir 😊

@BiologyLectures 3 жыл бұрын

Most welcome

@ICDSSupervisorExamGuide1 Жыл бұрын

thankyou so much sir,

@BiologyLectures Жыл бұрын

You are most welcome 😊

@dikshyapanthi7681 3 жыл бұрын

Excellent lecture 😃

@BiologyLectures 3 жыл бұрын

welcome

@willperez1107 2 жыл бұрын

very good

@BiologyLectures 2 жыл бұрын

Thanks you very much. please consider subscribing to support us.

@maume8278 2 жыл бұрын

Thank you so much 🙏🏼

@BiologyLectures 2 жыл бұрын

You’re welcome 😊

@stephenleighton4050 2 жыл бұрын

Question..... can anyone explain or give clarity on the following ... does any change to typical Purine & Pyrimidine, folate, B6 or B12 pathways during pre or early post natal periods result in heritable genetics that could be passed from that baby should they procreate in later life?

@vatsalbarad253 4 ай бұрын

Superb

@BiologyLectures 2 ай бұрын

Thank you.

@basharj7526 2 жыл бұрын

thanks for the great explaination ..... I just wanna ask about the resources you used plz as I want to go into further details ?

@BiologyLectures 2 жыл бұрын

Thank you. We used multiple resources . Please find the link below for one of the sources used w3.biosci.utexas.edu/atkinson/Epigenetics2014/Epigenetics2014/Readings_files/Ch%201%20Overview.pdf

@westfield90 10 ай бұрын

The level of the complexity of the body just went through the roof. Finding therapies and new drugs for diseases just became very very very difficult if genes are being turned on and off by almost any external factor.

@Priteshlodh 2 жыл бұрын

Hello Sir, does epigenetic changes are reverseible?

@BiologyLectures 2 жыл бұрын

Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence

@nixodian 2 жыл бұрын

Epigenetics and methylation same? Thanks for clarification

@BiologyLectures 2 жыл бұрын

In addition to methylation, epigenetics also contains histone modification.

@jitendrakanwar6125 10 ай бұрын

Can you explain the causes of epigenetics....🙏

@BiologyLectures 10 ай бұрын

Environmental Factors: Environmental exposures, such as diet, stress, pollutants, and lifestyle choices Developmental Processes: Epigenetic changes are crucial during development and can result from the sequential activation or inactivation of specific genes Disease and Pathological Conditions: Epigenetic alterations are implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

@amogelangsekhu3906 2 жыл бұрын

Does DNA methylation only prevent certain genes from being expressed ?

@BiologyLectures 2 жыл бұрын

Not all genes are active at all times. DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression.

@genetilocos3105 Жыл бұрын

I have a question that is making me sick. I thought that methylation should always be interpreted as a repressive mark. So, how is it that H3K4me3, H3K36me, and H3K79me for example could lead to gene expression}? thank you

@BiologyLectures Жыл бұрын

DNA methylation is a fundamental epigenetic event associated with physiologic and pathologic conditions, including cancer. Hypermethylation of CpG islands at active gene promoters leads to transcriptional repression, whereas hypomethylation is associated with gene overexpression. Reference: pubmed.ncbi.nlm.nih.gov/21692051/#:~:text=Background%3A%20DNA%20methylation%20is%20a%20fundamental%20epigenetic%20event,repression%2C%20whereas%20hypomethylation%20is%20associated%20with%20gene%20overexpression.

@genetilocos3105 Жыл бұрын

@@BiologyLectures thank you very much! I will check out the paper. So, there are histone's methylations that are repressive (like H3K9me3 or H3K27me3) and methylations that are permissive, right? Maybe it depends on context, signals, or that are made in different aminoacids? I will read the paper btw. Thanks again!