you dont know how helpful this video is. it actually explains everything unlike the other videos on this topic on youtube. everybody leaves out the parts after the AP reaches the sarcolemma, thats the most complicated part! thank you so much. (i was wondering where the extra calcium came from to shift the troponin-tropomyosin complex. this video cleared up so much)

This is the best description I've found for Excitation-Contraction Coupling. Thank you!

I never comment ever. But, after watching this video it helped me to understand this better than I ever have before. Thank you so much.

EXCELLENT DETAILS. Now I understand the Excitaion- Coupling for my mid term. all I got from lecture was a few bullets and pictures. I was confused on the T-tubles now I understand what they do. THANK YOU SO MUCH YOU ROCK!!!!

This is amazing. I am so glad there are videos like this to reinforce textbook information learning. Thank you!!

This video was very helpful and gave just the right level of detail, thank you!

omg this video is so good! I was looking everywhere for a good explanation for this concept and I found it here.

Very helpful video! That made so much sense

The calcium channels in the terminal cistern aren’t voltage gated they are mechanically gate. The action potential sweeping down the t-tubules stimulate a protein receptor called dhp which is attached to the mechanically gated calcium channels in the cistern. The stimulation of dhp causes it to change conformation and pull the calcium channel open allowing calcium to diffuse out of the sarcoplasmic reticulum and into the icf of the muscle, thus stimulating the muscle to contract.

Thank you for explaining the theory very clearly!

this is a good clear step by step video, watched several times

Thanks! cleared up a lot of confusion I had about the process...Keep making videos!

Wow! Great clear video!

Thank you, this video was extremely helpful!

Brilliant Video. Clear and concise.

Thanks! This Video was great

wow this really helped me! thank you so much!!!

Ryanodine receptors are mechanically gated calcium channels in the terminal cisternae.

Thank you, this is a great video and a very good explanation! Would've been helpful to mention the DHP receptor and the RyR, but still a good video.

Great explanation !

very well explained! thank you so much!!

Thank you! This helped me a lot!!

Best explanation video

That was... beautiful. :')

this was very helpful. thank you!

great video sir

Thanks so much! GREAT video!

Good video...does anyone here know what would cause muscle stiffness or rigidity that leads restricted movement? I am interested in this as i think many patients with neurological syndromes are often mis diagnosed.

brilliant! thank you so much!

Thank you so much !

Is the Muscle-Type Nicotinic Receptors ion channels for both Sodium and Potassium? Or is it the classic channel only for Sodium, which automatically triggers a muscle action potential?

best explanation! thank's!!!!

just learning this now in anatomy, still a bit confusing, but I'm picking it up a little better :) thank you.

Great Vid!

Great, thank you.

thanks got it clear.

Thank youuu Very helpful ☹️💞💞

Awesome!!!!!!!

Thank you a bunch! :D

same goes for DHP and RyR. That is a little deep for this level. Neither of those are covered in the 2 semester A&P texts I am using.

remember this geared toward 100-level A&P

So then what happens to the negative Cl ions during action potential?

Great video, but i don't like to use "stimulate" words, it's fuzzy, i think i will use something like "the neurotransmitter changes the 3D shape of the ion channel molecule by binding to it" because the world stimulate does not describe something on the atomic level. Just a personal opinion Any way good video

Loves ❤❤❤

nice

this was a very detailed video and was easy to understand. I'm hard of hearing though and the caption was difficult to follow. due to the high quality of this video, i think it'd be worth adding your own closed captioning. it was slightly funny however that the caption kept changing myosin to my ass. 😃

Your illustrations show all ions as positive. Is this accurate. Wouldn't either Ca, Na, or K have to be negative somewhere to cause voltage changes/action potential. Other illustrations show Na as negative. Please explain.

StudentHelp4AP (below)

Not that great. Doesn't go into much depth.