Exercise and Insulin Stimulated Glucose Uptake by Skeletal Muscle

Рет қаралды 146,842

9 жыл бұрын

Пікірлер: 97

@IvanBFit 5 жыл бұрын

This is a SPLENDID MARVELOUS presentation! Very well done :-) Just EPIC and cutting-edge. Very well articulated and broken down. Animation was incredibly precise.

@joeimama Жыл бұрын

I just watched a video of some australian scientists that have hypothesized that the insulin receptor site is functional in type 2 diabetics, but underneath its not correctly phosphoralizing IRS1/2 thus not beginning the cascade. I exercise daily and notice that my blood sugar always spikes for like 15 mins before it begins to drop. Probably because AKT doesn't get activated until I put enough stress on my muscles and/or its using up its existing glycogen stores until the stress begins. Then I can effectively drop my sugars continuing to exercise. This video is great as it visualizes the mechanism that I was wondering. Thank you.

@FrancescoRogai 17 күн бұрын

This is why you should train high intensity, Doctor Doug McGuff explains it clearly in the book Body By Science

@tunerd1921 4 жыл бұрын

THIS IS SO COOL!! The animation is amazing, always been envious of people who were amazing at science AND art... I can barely draw a smiley face. Well done! Love this video

@neji161718 5 жыл бұрын

I fall in love with her voice.

@colecoleman1499 Жыл бұрын

Fell*

@aligrafix1985 7 жыл бұрын

Fantastic way to explain!

@tnijoo5109 Жыл бұрын

Brilliant video! Exceptionally well done.

@inigosanmillan1 7 жыл бұрын

Outstanding Presentation. Congratulations and thank you very much for the effort.

@christophernieves1215 3 жыл бұрын

Perfect explanation!

@MaximumMetal123 7 жыл бұрын

This is awseome! So helpful thank you!

@alejandravasquez3837 2 жыл бұрын

Amazing! Thank you.

@saranadeem8567 2 ай бұрын

Literally FANTASTIC

@dianeladico1769 Жыл бұрын

That was PERFECT-thank you!

@EA-rn3tx Жыл бұрын

This cleared up so much. Thank you!

@doctormwpepper 7 жыл бұрын

Thank you so much for this. Actually an amazing video with thorough information, and a very peaceful experience overall. Preparing for the USMLE and need more of this zen.

@maramadel415 8 жыл бұрын

That's been pretty useful, thank you. Consider making more videos :"D

@chachi_luna 4 жыл бұрын

Love flight facilities, and physiology of course

@emilna3212 6 жыл бұрын

Great video!

@pariszar7859 7 жыл бұрын

Great job !

@aadt4604 3 жыл бұрын

Great video , it makes clearly explanation

@maskofsorrow Жыл бұрын

Brilliant explanation and animation.

@danieldaneshforouz1394 8 жыл бұрын

Awesome video!

@sumitgupta4414 6 жыл бұрын

great animation ...making interesting ..thank you 👍👍👍👍

@prdgy132 5 жыл бұрын

AMAZING VISUAL

@joaoflaviobaeta 7 жыл бұрын

Perfect!!!

@natto84 2 жыл бұрын

Wow, this was great.

@WeedmanSmokes805 6 жыл бұрын

I feel so relaxed

@LayZeeBro 7 жыл бұрын

perfect.

@carmenross1077 Жыл бұрын

I like this demo reminds me of my class rather than listening to talk talk talk at least something being pictured in my brain

@m.m.m.c.a.k.e Жыл бұрын

Very nice! 🎉

@RIO4252 4 ай бұрын

thanks... so Nice..

@faisalalmutairii 2 жыл бұрын

Great video 👏🏻

@maduraikalatta5698 Жыл бұрын

Very nice video thanks

@infopc-arieh6372 8 ай бұрын

Excellent ... well done ...

@jakecattoi4983 Жыл бұрын

amazing ASMR video

@fatemhalasfar4057 Жыл бұрын

Amazing 👏

@loganausleyreal-eyes8090 3 жыл бұрын

This is very elaborate. Well illustrated with the animation. So I guess that training in a persons state would allow for better glucose uptake due to the action potential rather than insulin driven. Depending on the severity or level of insulin resistance. And I’m wondering how Leptin comes in to play. You consume carbohydrates the night before training this Stimulates insulin as well as leptin secretion.

@isabelhuang_1 3 жыл бұрын

The whispering from my left earbud gives me tingles up my spine alkhjkfgdh

@khalid6050ify Жыл бұрын

Excellent

@25parneetkaur8 5 жыл бұрын

All the best mam for your future videos

@25parneetkaur8 5 жыл бұрын

Its realy osam mam to understand action of glut 4 Which i cant ever understand by my teachers theoratically

@liliancuryhadad 26 күн бұрын

Sensacional❤

@HousewerkRecords Жыл бұрын

Good technical presentation. Does the same regular or rigorous exercise regime work for type 1 diabetes?

@tobiaschristianbisgaard4628 8 жыл бұрын

This video is freaking awesome! Trance voice and music made me focus haha. 5/7

@katiemeredith 7 жыл бұрын

best track!! It's Clair de Lune by Flight Facilities..

@ChildFromGeorgia 3 жыл бұрын

wow great job!

@CaptainVelveeta 7 жыл бұрын

Wow...fantastic animation...what company is this...I could really use this quality of animation in my Microbiology class right now.

@bubbagene145 6 жыл бұрын

What the ..... I'm so stoned and watching this. This is incredible.

@JohnSmith-rj2yt 6 жыл бұрын

How does exercise relate to the insulin signaling pathway?

@Ethereal_Ghost 5 жыл бұрын

wow...such an amazing video, it motivates me to exercise more as a prediabetic.

@stefanweilhartner4415 3 жыл бұрын

look into potassium or snake juice. lower cortisol which lowers gluconeogenesis. understand that every cell NEEDS to be insulin resistant from time to time

@Acts-1322 Жыл бұрын

Exercise And whole foods + water less manufactured/processed like baked goods and juices/beverages or smoothies, some days just OMAD(One meal a day)

@hoebeng1 8 ай бұрын

Will it affect the A1c result?

@smh7192 6 жыл бұрын

please make sound available on both speakers (left and right)

@deekshanyaj_3714 Жыл бұрын

The animation and explanation are very useful to understand...Thanks😃

@drewcrawford394 Жыл бұрын

Loved it👏

@T.R.A.I.N.I.N.G. 3 жыл бұрын

good video

@zyprozenin 5 жыл бұрын

What about for T1 Diabetics? Some T1 patients have BS spikes after exercise

@chazwyman8951 Жыл бұрын

GOsh I'd not realised how simple the process is.

@JakeMarian 4 жыл бұрын

How come could someone dislike this video?

@hineskittvelvett198 7 жыл бұрын

You mean we know about the tpgb going into cbgbs and transporting ttsdghgfds4s but we don't know why insulin sensitivity sometimes lowers?

@tartanhandbag 6 жыл бұрын

the techniques for working out which protein goes where and does what is just a matter of good molecular biology methods and the accumulation of several teams worth of research over some years. the actual cause for insulin resistance is so much more complicated. diabetes type 2 is one of the more complex diseases to understand. as with many "complex" diseases, it combines a number of vastly complex systems: immune regulation, vascular science, nutrition and the biochemistry of metabolism, genetics (MANY genes implicated) etc we do have some leads but it's not as simple as "this microorganism pumps out this toxin and boom - disease" this is a good start, although the paper is a little old now: www.ncbi.nlm.nih.gov/pubmed/16563942

@GuroJeromeTeague 4 жыл бұрын

According to my text book the decrease in insulin sensitivity in Type II Diabetes is caused by down regulation of cell receptors. In order to maintain proper homeostatic balance, cells that are constantly exposed to high levels of insulin caused by high level of glucose in the bloodstream will loose insulin receptors. On the reverse side, this is why low carb diets and moderate to high intensity training works to treat Type II Diabetes. Lower glucose in the blood stream leads to lower insulin in the blood stream and the cells respond by creating new insulin receptors (up regulation).

@Sam-vn9jm Жыл бұрын

Is that flight facilities in the background

@destinationunknown4959 3 жыл бұрын

She did not say how long a vigorous excercise is needed before the glucose is uptaken. A patient said he measured his glucose before a 15 min run and after and only 15 min of very fast sprinting reduced his BG by a significant amount. I am interested in knowing how long for and when does the glucose uptake stop if so. And 8f it runs out of blood glucose does it tap into Glucagon stores?

@tnijoo5109 Жыл бұрын

Interesting!

@kristina9605 3 жыл бұрын

This is so cool! It left me with the question of how muscles obtain energy when people are on low carb diets and aren’t consuming sugar? Do they conserve the little glucose they do have, or can fats and proteins also be converted to glucose?

@destinationunknown4959 3 жыл бұрын

Yes fat and protein then convert to glucose.

@Moxieinmotion 2 жыл бұрын

Fat gets converted to ketone bodies in the absence of insulin, OR gets put into storage in the presence of insulin. Amino acids can be converted into glucose via gluconeogenesis

@RobyVicary 5 жыл бұрын

Skipped a step at 2:30 - PIP3 activates PIP3-dependent-kinase-1 (PDK-1) which activates PKB/Akt. See: PMC3941218

@RobyVicary 5 жыл бұрын

But a good video nonetheless :)

@aud4837 2 жыл бұрын

What Pharmaceutical Company are you representing?

@tomdelorenzo2539 4 жыл бұрын

Kinda ignored all the GLUT1 transporters that all muscle cells have.

@shaikfairoj5172 Жыл бұрын

👏

@DeadLifts4Dayz Жыл бұрын

I’m just here to Build Lots of muscles

@alanboo5664 3 жыл бұрын

But sometimes I wonder after a strenous workout I have seen my CGM shows high readings..It stars giving me speech alerts. I dont understand why..?

@destinationunknown4959 3 жыл бұрын

Because it is dumping from the liver stores. Normal as far as I read.

@CzechRiot 8 жыл бұрын

The only problem is the way the woman speaks is like those hypnotic relaxation types of speeches... "feel your body relaxing... let your mind travel to another dimension... flow weightlessly through space..."

@CzechRiot 8 жыл бұрын

I mean, it's hard to focus technically in the video, as I feel like going into a trance.

@InZainUK 7 жыл бұрын

and the song too, its a bit of a banger.

@doctormwpepper 7 жыл бұрын

I love the way she talks. Soft spoken, easy on the ears. Very zen.

@gwwasham 2 жыл бұрын

This music is creepy. It sounds like a horror movie.

@unknownworld9815 Жыл бұрын

i may not understand but i know exercise increases insulin sensitivity

@Sollirep 6 жыл бұрын

Huh?

@MrPokerblot 7 жыл бұрын

So skeletal muscle doesn't need insulin to use glucose at all?

@atomicpiano 6 жыл бұрын

Whaaaaaaaaat

@CJVP99 8 жыл бұрын

good video but whats with the demonic background music?

@chriskim9470 8 жыл бұрын

Haha, how does it sound demonic? It's mellow and chill.

@swobodams 4 жыл бұрын

I need a nap.

@emmauya3198 Жыл бұрын

You have my maximum respect Dr Igudia, I am now negative from my type 2 Diabetes after I did the test, I wonder what might have become of me it I didn't get the herbal cure From your KZfaq channel. God bless you sir.