With increased efforts to decrease opioid prescribing for chronic pain conditions, the non-opioid analgesics and co-analgesics are being more widely utilized. Skeletal muscle relaxants (SMRs) are frequently used chronically despite a paucity of data supporting this practice. Without a clear base of evidence, a thorough understanding of the pharmacologic profile of these agents is essential when selecting therapy. This session will present the class of SMRs in their entirety, review commonly accepted mechanisms of action and challenge widely held beliefs regarding the appropriate place in therapy for this drug class when treating chronic pain.