From long-lived animal species to human interventions

From long-lived animal species to human interventions | Prof Vera Gorbunova

Рет қаралды 6,187

Күн бұрын

In this #webinar, Prof Vera Gorbunova, Professor of Biology and Medicine from University of Rochester, discussed the link between mammals with long lifespan and their resistance to cancer, and how understanding the underlying molecular mechanisms driving this phenomenon can be immensely valuable to human health.
Register for upcoming #HealthyLongevity #webinar sessions at nus-sg.zoom.us/webinar/regist...
#NUSMedicine #webinarseries
References:
- Closing video source: • Comparisons: Animal Li...
Disclaimer: The opinions and advice expressed in this webinar are those of the speakers and do not represent the views and opinions of the organizers and National University of Singapore or any of its subsidiaries or affiliates. The information provided in this webinar is for general information purposes only as part of a general discussion on public health. The information is not intended to be a substitute for professional medical advice, diagnoses or treatment; and cannot be relied on in place of consultation with your licensed healthcare provider.
All Rights Reserved.
All of the proceedings of this webinar, including the presentation of scientific papers, are intended for limited publication only, and all property rights in the material presented, including common-law copyright, are expressly reserved to the speaker or NUS. No statement or presentation made is to be regarded as dedicated to the public domain. Any sound reproduction, transcript or other use of the material presented at this course without the permission of the speaker or NUS is prohibited to the full extent of common-law copyright in such material.

Пікірлер: 17

@peterz53 2 жыл бұрын

Thank you, I never miss a talk by Prof. Gorbunova.

@BrandonSLockey 2 жыл бұрын

agreed, talk is pretty mindblowing, what if we express Bowhead Whale SIRT6 in humans 👀

@peterz53 2 жыл бұрын

@@BrandonSLockey Exercise appears to upregulate SIRT6. In another recent presentation VG shows that BWs use an upregulated gene (compared to us) called CIRBP which appears to be a response to cold adaptation, and is the BW's way to maintain genome stability. Core body temp in BW is 2 or 3 degrees lower than ours. There is some evidence that cold exposure will increase expression of CIRBP in other mammals, at least transiently.

@akirawu54711 2 жыл бұрын

Excellent presentations, looking forward to more, thanks 👍

@jamesf7933 2 жыл бұрын

Thanks so much to Prof. Gorbunova, Prof. Kennedy, and others for making this informative presentation, comments, and Q&A to the public! Really enjoyed all of it. An observation: after beginning consumption of fucoidan, mice experienced a reduction in frailty. I would expect biological age to remain steady or slow down if DNA repair is up-regulated, but not necessarily reversal of age symptoms. Does the reduction in frailty mean that pre-existing DS DNA breaks were repaired, or that prior DNA damage (from improperly repaired breaks) was fixed? Or do deacetylation or mono-ADP-ribosylation have beneficial effects in addition to just DNA repair?

@agingresearch960 2 жыл бұрын

If you ask me the data is too preliminary to answer that. It is not clear whether aging was reversed, slowed or whether Fuc somehow just increases "fitness" from this graph. It would take a longitudinal analysis to really figure that out (as you can see there is no baseline data in the graph so we do not know if and how it changed over time). Also usually we like to run that kind of experiment for 6 to 12 months to give reliable data.

@peterz53 2 жыл бұрын

SIRT6 and Fucoidan: Here is a 2017 paper which identifies several brown algae species which activate SIRT6 - www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5484140/pdf/marinedrugs-15-00190.pdf of the 5 species studied, Fucus dichitus had the most effect.

@rosspelton3855 2 жыл бұрын

I would like to get a high-resolution copy of the slide Dr. Gorbunova showed in her presentation on Interventions that regulate genes correlated with MLS. Where was the information on that slide published....???

@Efiroboti 2 жыл бұрын

Very interesting

@luckssj Жыл бұрын

Have you investigated the Glycocalyx Structure that may become the next important thing in nutrition?

@kamanashisroy 2 жыл бұрын

What about black elderberry and anthocyanins

@leeoxford 2 жыл бұрын

Vera is aging slowly.

@malinskytt9242 2 жыл бұрын

I don’t know how old she is but her skin is however amazing!! 😊

@surfreadjumpsleep 2 жыл бұрын

Why do I suddenly have no trust in professor Gorbunova? Selling supplements with do not age (what seems like a glorified drop shipper) and elysium (a well funded, star studded drop shipper). Collecting a check from her employer meanwhile using her research to sell supplements.

@naromsky 8 ай бұрын

Yeah. Looks too good/simple to be true.