Stress can be defined as the disorder of the “dynamic balance” of an organism. This balance is regulated by a system in the brain and body, called “stress system”. When stress is successfully treated by this system, the results are neutral or even beneficial to the organism. However, when the initial balance is not restored, a condition that is defined as “kakostasis” devastating effects can occur. Paradoxically, the main beneficial hormones called “stress mediators” are responsible to a considerable extent for the damage suffered by the body under kakostasis. When they are not secreted properly and for a long time during chronic stress, speed up aging, cause psychosomatic problems and increase the likelihood of infection and carcinogenesis in the body. Today, the presence of kakostasis can be assessed and rated in subjects. There are methods of prevention including lifestyle changes, behavioral therapies and use of appropriate medications. The nature of man, therefore, is not destiny and mental and physical resilience to stress (yperstasis) is possible, if we really look for it.