Geraldine Hamilton: Body parts on a chip

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TED

TED

10 жыл бұрын

It's relatively easy to imagine a new medicine, a better cure for some disease. The hard part, though, is testing it, and that can delay promising new cures for years. In this well-explained talk, Geraldine Hamilton shows how her lab creates organs and body parts on a chip, simple structures with all the pieces essential to testing new medications -- even custom cures for one specific person. (Filmed at TEDxBoston)
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Пікірлер: 347
@ja100o
@ja100o 5 жыл бұрын
3:01 Cameraman: "just f**king hold that damn thing still for a moment!"
@JohnLeePettimoreIII
@JohnLeePettimoreIII 5 жыл бұрын
😃
@niroopotsav
@niroopotsav 5 жыл бұрын
xDDD
@iliketrains0pwned
@iliketrains0pwned 5 жыл бұрын
"I have right here a human lung on a chip!!" *_frantically starts waving it back and fourth so the camera can't see it_*
@brosephthomas3764
@brosephthomas3764 4 жыл бұрын
3:00 Props to the camera operator for at least trying to catch a decent view of the chip even though failure was inevitable in this situation.
@jacobduncan87
@jacobduncan87 5 жыл бұрын
It's been 5 yrs I wonder how much of this has been integrated like predicted.
@paulvarn4712
@paulvarn4712 5 жыл бұрын
Good question now on Apr 8 2019. This is the latest science article I could find on Emulate: techweek.com/organs-on-chip-emulate-boston-startup/
@jacobduncan87
@jacobduncan87 5 жыл бұрын
@@paulvarn4712 thanks pretty interesting article.
@estuardochoc
@estuardochoc 5 жыл бұрын
This month it arrived to the international space station!
@OphiuchiChannel
@OphiuchiChannel 4 жыл бұрын
Its fascinating... I cant say I understand 100% how the valves works but I wish I knew more.
@aracaribiosciences6124
@aracaribiosciences6124 4 жыл бұрын
We've been implementing this for a while now.
@SIMKINETICS
@SIMKINETICS 10 жыл бұрын
I've worked as an engineer/scientist in the bio-medical industry for decades. This technology of a cheap, mass-produced lab-on-a-chip is widespread throughout the industry because it's a versatile means of increasing efficiencies in testing. Microfluidic chemistries & bioassays can be deposited, dried & activated later with fluid injection at the time of testing. This can eliminate a complex protocol for preparing reagents for every test at the urgency of time-sensitive processes; this saves a lot of lab work & time. Channels encased in clear plastic can be used to create circuits that are isolated from contamination, while allowing non-contact fluid circuit actions urged on with localized heat, capillary action, magnetic sturrers & gates, & sound waves that do not foul the circuit. This also allows microscopy to be used in pre-calibrated instruments fitted to accept these chips. This is a new way of thinking that has many uses that imaginative engineers & scientists can exploit, though it's decades old!
@mustafamahmoud4317
@mustafamahmoud4317 8 жыл бұрын
hi SIMKINETICS your comment it very interested for me and I need your help about this field for applying these ideas my email is muattia@gmail I hope you send me you contact
@SIMKINETICS
@SIMKINETICS 8 жыл бұрын
mustafa mahmoud My e-mail is screwed up. Please communicate through my KZfaq channel comments.
@Creationsofmyown
@Creationsofmyown 5 жыл бұрын
The Thought Emporium just uploaded a video about how basically anyone with the know-how can make a microfluidic chip with ShrinkyDinks for pennies on the dollar...
@joalexsg9741
@joalexsg9741 6 жыл бұрын
Just amazing! Thank you so much for one more educational TED video-lecture!
@IMBIue
@IMBIue 10 жыл бұрын
Pretty impressive. I can't wait to see what the future holds in medicine. Good luck towards the team working on this :D
@LangeE612
@LangeE612 10 жыл бұрын
This blew me away. Awesome!!
@mysterygideonman
@mysterygideonman 10 жыл бұрын
This is bloody brilliant! It might be that i'm a little late but this was a real eye opener for me. The amount of possibilities of this technology is mindblowing. I knew that this kind of technology did exist but I never could have imagined that it would be this elegant and beautiful. Complicated yet simple.
@Cynthia_Cantrell
@Cynthia_Cantrell 5 жыл бұрын
I took a bunch of these organs-on-a-chip, added some motors, a Raspberry Pi 3B+ for a brain, and made a miniature cyborg boy in my basement. I named him Chip.
@timirbaranmaiti4045
@timirbaranmaiti4045 Жыл бұрын
Amazing concepts to know through a great presentation .it must bring revolution in medical treatments .
@Aeig
@Aeig 10 жыл бұрын
What a great speaker
@codyvanloan6159
@codyvanloan6159 10 жыл бұрын
Very exciting concepts for the health industry and many others. I can't wait to see how this could possibly revolutionize the treatment of diseases.
@dewaldjohan
@dewaldjohan 10 жыл бұрын
i love seeing 05:40 its incredible! visual presentation of whats happening inside our bodies
@turalmustafayev3757
@turalmustafayev3757 7 жыл бұрын
nice explanation!
@evgeniisharaborin8071
@evgeniisharaborin8071 3 жыл бұрын
I am amazed totally!
@ClemonsKunkel
@ClemonsKunkel 5 жыл бұрын
Wowing. Love this Video. TED talks really keeps you up-to-date once but changing in the world. Awesome ideas. It will save a bunch of lives in the near future.
@Poollz
@Poollz 10 жыл бұрын
wow wow wow! simply amazing what they are doing
@angynan3217
@angynan3217 10 жыл бұрын
Me parece muy interesante, y sería posible diseñar el uso racional del medicamento en los diferentes pacientes
@nebuchadnezzar47
@nebuchadnezzar47 4 жыл бұрын
I would really love to see an update on this technology, so see how far this technology is today, 7years later
@FadiHamoud1980
@FadiHamoud1980 10 жыл бұрын
Very ingenious! I love it.
@deliciousbutter6077
@deliciousbutter6077 10 жыл бұрын
Wow this so genus and simple! I mean it's probably is very complicated to figure out and engineer but it's so much more simpler than so many other things
@TheSteezyCheese
@TheSteezyCheese 10 жыл бұрын
Very cool, the next step towards better treatments
@HugoOliveirapt
@HugoOliveirapt 10 жыл бұрын
Thanks you
@fatmaelsayed8933
@fatmaelsayed8933 Жыл бұрын
soooo informative
@nozrep
@nozrep 8 жыл бұрын
simply amazing
@user-xv2hh4ki3m
@user-xv2hh4ki3m 3 жыл бұрын
This is so amazing omg
@fjoa123
@fjoa123 10 жыл бұрын
for me its pretty hard to believe that things like these are happening just at the same time as people fighting and killing because of religion.
@Memera94
@Memera94 10 жыл бұрын
s0be2266 i think you are special
@stuart2964
@stuart2964 10 жыл бұрын
Actually they are not fighting because of religions, religions are spiritual endeavours, what creates war and death from religion / resources is their EGO creating a false reality that only their way is correct, their God is bigger and better and the only God, to heal the planet most effectively we need to learn that WE are not always right from our world perspective and accept others ways and beliefs even when they disagree with our own.
@fjoa123
@fjoa123 10 жыл бұрын
s0be2266 would you please bother on giving at least one argument?
@zvolencan1
@zvolencan1 10 жыл бұрын
You got it all wrong. People fight over natural resources and power and cover it with religion differences (and spreading of "democracy").
@s0be2266
@s0be2266 10 жыл бұрын
c7b0rg I was thinking more along the lines of what zvolencan1 had posted. But if it makes you feel any better ur special too.
@lucstockdale
@lucstockdale 10 жыл бұрын
This is amazing.
@theropes25
@theropes25 10 жыл бұрын
Amazing!
@Dem00000nN
@Dem00000nN 10 жыл бұрын
Very intresting!
@user-yw8sr3uj1w
@user-yw8sr3uj1w 4 жыл бұрын
This is awesome!
@BosonCollider
@BosonCollider 10 жыл бұрын
Her graph at the beginning of the presentation on drugs follows the inflation curve for the US dollar exactly...
@567BTHTY
@567BTHTY 10 жыл бұрын
haha great comment, always good to be critical
@DarkFox2232
@DarkFox2232 10 жыл бұрын
Well inflation may be changing similarly to that graph, but it does not mean same amount of new medicines got out for same percentage of GDP. US inflation from 1980 to 2010 is around 180% (lets say 2x), but since graph has exponential scale it shows that number of new drugs per 1B$ went in years 1980 - 2010 from 4 to 0.6. US GDP got in 1980 to 2010 from 2.8 to 15 trillions $. What does it mean? (Drugs * inflation / GDP 1980 to 2010 ratios) 0.15 * 2 / 5.3 = 0.056. Shes very right that effectiveness goes down, and in given time here it is by factor of 17.
@BosonCollider
@BosonCollider 7 жыл бұрын
Fox2232 Pretty sure you shouldn't be dividing by 5.3 there, since that's the 2010 to 1980 gdp ratio, not the other way around. Yield of new medicines for a given percentage of GDP has increased, not decreased.
@brosephthomas3764
@brosephthomas3764 4 жыл бұрын
Just imagine the personalized medication we'll have in the future thanks to this tech! No more extensive lists of side effects for the drugs people rely on.
@maynorarturovidesvasquez
@maynorarturovidesvasquez 10 жыл бұрын
Amazing!!! :)
@BlackMenTakingOurCommunityBack
@BlackMenTakingOurCommunityBack 10 жыл бұрын
Awesome video
@tjdoss
@tjdoss 10 жыл бұрын
Astonishing.
@CarmeloUrena94
@CarmeloUrena94 10 жыл бұрын
THIS IS AWESOME!!!!
@egidiocs
@egidiocs 10 жыл бұрын
fantastic
@TooIrishProud
@TooIrishProud 10 жыл бұрын
Impressive, exciting, and potentially revolutionary!
@cineck
@cineck 10 жыл бұрын
This is pure SF happening right now. Amazing.
@cliffdannau
@cliffdannau 10 жыл бұрын
this is amazing :o
@PedroPampolim
@PedroPampolim 10 жыл бұрын
Great stuff
@matrix011101
@matrix011101 10 жыл бұрын
wow
@Mithon81
@Mithon81 10 жыл бұрын
Consider how production of the transistor has evolved. How large it was in the beginning, and how small it is today (and getting smaller). If we see anything like that development for a technology such as this, imagine the statistical plausability you could get for medical trials at an insanely low cost. Truly exciting...
@smitalmehta7735
@smitalmehta7735 10 жыл бұрын
its going to save lots of time n energy and of course if it will be used wisely, its gonna save lots of lives also.. great great great.... Hates off..
@brunoperez1211
@brunoperez1211 5 жыл бұрын
Pero muy bien
@AhmedEssam_eramax
@AhmedEssam_eramax 10 жыл бұрын
great
@HelenaMisfit
@HelenaMisfit 10 жыл бұрын
This absolutely blew my mind when I heard this. Could you imagine how this would revolutionize the way we study cells. Amazing!!
@dnadirective
@dnadirective Жыл бұрын
9 years later...how did this chip pan out? Is it industry standard now or ultimately did not commercialize well?
@tonyotag
@tonyotag 10 жыл бұрын
how about synthetic photosynthesis with these chips?
@lulus704
@lulus704 8 ай бұрын
has anything happened with this in the last 9 years or can you do a follow up talk to this
@nuvamusic
@nuvamusic 10 жыл бұрын
I believe this works for the early phases of a drug research, by eliminating at once the prototype drugs that don't pass this initial safety test. Further clinical trials will still be needed for those that pass. A human body as a whole is way more complex than what has been depicted in these examples. So many possible multi-organ or multi-systemic interactions, too many variables involved. In vitro still from in vivo.
@TanTan-ch3vq
@TanTan-ch3vq Жыл бұрын
Agree
@enduraman1
@enduraman1 10 жыл бұрын
That's awesome medical technology to personalized medicine.
@indianstunts
@indianstunts 10 жыл бұрын
Interesting idea! But it seems that they are creating physical stress environs, I am curious, what about creating the chemical environment like ph levels, salt and juice levels which help in functioning and immune reactions? What about the neurological connections, the interconnections of nearby organs, bones, tissues etc which effect the response of a particular organ? What about creating any preconditions or deficiencies, diseases which affect bodily responses? If these can be done it will be revolutionary. Keep going! My best wishes.
@nickm2137
@nickm2137 10 жыл бұрын
This technology is amazing and I can't wait to see this being used. I would like to see this technology combined with 3D printing, the possibilities are endless.
@wonderfulJJ
@wonderfulJJ 10 жыл бұрын
impressive
@mscocokaka1
@mscocokaka1 10 жыл бұрын
It should be able to use in Lap
@SangoProductions213
@SangoProductions213 10 жыл бұрын
Hell yeah!
@turalmustafayev3757
@turalmustafayev3757 7 жыл бұрын
please show the reference!
@Cartwrightsrule
@Cartwrightsrule 10 жыл бұрын
Brava
@DouglasWilliamsPDX
@DouglasWilliamsPDX 10 жыл бұрын
Really kool tech
@sourabhbhavsar4020
@sourabhbhavsar4020 10 жыл бұрын
Facinating! Medical system is going to be something else in next 10 years.
@niveoserenity5862
@niveoserenity5862 10 жыл бұрын
The future is amazing.
@MonsterSlayer14
@MonsterSlayer14 10 жыл бұрын
What a clever idea
@alanfertom6354
@alanfertom6354 10 жыл бұрын
My mind=blown!!!!!!
@terro28
@terro28 10 жыл бұрын
what about the reactions due to hormonal responds?
@user-gs1jh7vb1t
@user-gs1jh7vb1t 4 жыл бұрын
So.. does anyone know how this study is going right now during Covid-19?
@gyice
@gyice 10 жыл бұрын
It will be interesting what takes place once the technology reaches the field and the true innovation starts.
@4Dustorm
@4Dustorm 10 жыл бұрын
I'm proud to cal who ever made that a true engineer
@dominic508
@dominic508 10 жыл бұрын
This is reeeaaally cool, but I think bio-printed organs have more potential. As she said herself in the beginning, we have to get the closest possible to the actual environment of the human body.
@HamsterPants522
@HamsterPants522 10 жыл бұрын
I agree. Though it's good that this option now exists. It seems like it would be more affordable than bio-printing, so maybe it could be more useful in poorer countries? If it's able to be, then that is still very good news.
@MrFlexNC
@MrFlexNC 10 жыл бұрын
Yes but it is economical not possible. This is a faster, cheaper and more feasible way. Keep it simple and stupid ;)
@joshlee1090
@joshlee1090 10 жыл бұрын
I don't see how bio-printing is at odds with this technology. It seems they would work cooperatively.
@slicedtoad
@slicedtoad 10 жыл бұрын
HamsterPants522 It's a research tool... Since when is pharmaceutical research done in poor countries?
@HamsterPants522
@HamsterPants522 10 жыл бұрын
slicedtoad Well I said poorer, not necessarily poor.
@coolineho
@coolineho 5 жыл бұрын
We need to fight for the feelings of these chips, it's our duty.
@jackson12200
@jackson12200 10 жыл бұрын
Will they be able to host cancer cells also if so this is awesome
@drra4951
@drra4951 10 жыл бұрын
what institute is that ?
@snowkid6285
@snowkid6285 10 жыл бұрын
yay~!
10 жыл бұрын
I think this is all amazing, but I can't imagine how are they going to get for example cells from samebody's heart, or liver without an operation. Do you guys, have any idea?
@KemaTheAtheist
@KemaTheAtheist 10 жыл бұрын
Right now, it's called a biopsy, and they are fairly non-invasive thanks to laparoscopic surgery. Once induced stem-cells are improved, that's how it will be done.
@mussoorie111
@mussoorie111 10 жыл бұрын
There are a tonne of biochemical transmitters around that we don't even know exist. How Wil be able to explain the cause for the effect they see on these isolated chip environments??.
@VisualArt3D
@VisualArt3D 10 жыл бұрын
Amazing technology!!! But there is something about it that just doesn't feel right... I think we have to be very careful what we make of this technology
@reddragon9918
@reddragon9918 10 жыл бұрын
She sure says beautiful a lot!
@brosephthomas3764
@brosephthomas3764 4 жыл бұрын
I would too. This tech is amazing!
@mshmbo
@mshmbo 10 жыл бұрын
Hot topic with very cold audience !!
@Abraxis86
@Abraxis86 10 жыл бұрын
Dr. Vahlen!!
@MathieuHautefeuille
@MathieuHautefeuille 10 жыл бұрын
Interesting talk from Geraldine Hamilton about what can be made on a chip. Further than a Lab on a chip, now we're talking organs on a chip. This could help designing and testing new drugs but it could also be useful for ex-vivo cell culturing where cells could behave more like how they do behave in the body. Structuring the chip walls to mimick the natural environment of the cell is indeed important to ensure their culturing. And being able to feed the cell with microfluidics is also a key factor that this kind of chips permits. We'll see how this technology evolves and progresses...
@doloresmanrique9183
@doloresmanrique9183 10 жыл бұрын
Increible
@Magykman
@Magykman 10 жыл бұрын
I hope this is what the medical industry needs to develop new medicines and vaccines.
@psetnapskaena7642
@psetnapskaena7642 10 жыл бұрын
Bookmark 8:30
@nunyabiznez8120
@nunyabiznez8120 5 жыл бұрын
Problem is, that the test the drug on the whole body. Drugs affect the entire machine, not just 1 part. Humans are not cars or computers. Because of how they interact and how a drug can concentrate in one location more than another, this will not be able to give the full picture. Its great if it stops heart disease, but its not any good if it concentrates and kills off your liver...
@shrunkensimon
@shrunkensimon 10 жыл бұрын
Interesting stuff. The chips are still isolated islands of functionality though so you may not be able to recreate the conditions that only a whole body could produce.
@Jonarrthan
@Jonarrthan 10 жыл бұрын
I think the point is it is it is better than what is availible now
@neurelfeilon8569
@neurelfeilon8569 10 жыл бұрын
The idea is valid. With development the probability of a correct prediction will rise significantly. And short of growing a clone it will probably be the best method we will ever devise. It no doubt is already [in this early development stage] better than all other methods we have combined.
@slicedtoad
@slicedtoad 10 жыл бұрын
Researchers would understand this. It doesn't replace all other tests, it's just a useful tool to add to the pharmaceutical chemist's collection. Being able to see exactly what happens in a micro system where all the variables are visible and controllable is very useful.
@shrunkensimon
@shrunkensimon 10 жыл бұрын
Jonarrthan Yeh for sure, don't doubt this is a better way of doing things, just saying that it probably won't ever be able to recreate the 'whole body' situation that comes from the sum of all the parts.
@xxhellspawnedxx
@xxhellspawnedxx 10 жыл бұрын
Neurel Feilon Growing a clone would still mean you had to pass all the stages of testing up to human trials - The clone would be every bit as sentient a being as the original its genetic material was taken from.
@realsteinberg
@realsteinberg 8 жыл бұрын
so fucking cool
@AnalAvenger
@AnalAvenger 10 жыл бұрын
"Ghost in the Shell" type future anyone? Yes. That's the answer. Its no longer a question. Its only a mater of time before we begin building more complex "organs". Having them work in conjunction would, by then, be mere childs play.
@faaip0de0oaid
@faaip0de0oaid 10 ай бұрын
9 years ago? i wonder what has been devoleped with this
@user-ny3uk6wv8p
@user-ny3uk6wv8p Жыл бұрын
I think this developed technology itself is very wonderful. However, based on the speaker's presentation, could it be that, prior to this technology, pharmaceutical companies had not fully clarified the effects of expected medicinal ingredients on the human body in the first place? Does it mean that detailed basic research on the possible negative effects of pharmacological ingredients on the human body as a whole and detailed clinical research on the negative symptoms observed as a result of these effects are hardly being conducted?
@percevalmahpouyas9933
@percevalmahpouyas9933 11 ай бұрын
I think they are thinking about the consequences that could have if it ever goes wrong. It can make a scandal if we talk about volunteers who end up being endangered by those trials. We're still talking about Big Pharma. Their goal, as for every company, is to make money, nowadays more than ever. And a good way to "make" money is to save as much as possible, starting by the clinical trials and the test subjects. A mouse, rat, or rabbit is infinitely less expensive in case of failure than a human subject. Avoiding expensive lawsuits is also part of the process.
@bnewton81
@bnewton81 10 жыл бұрын
When I eat while naked I sometimes get my body parts on my chips.
@zefellowbud5970
@zefellowbud5970 5 жыл бұрын
I want a doll that uses these chip and we essentially have a homunculus
@LarsKidev
@LarsKidev 5 жыл бұрын
Infinity Stones @ 1:30
@alfaphone3675
@alfaphone3675 2 жыл бұрын
Naftali benet?
@zoyeHow
@zoyeHow 10 жыл бұрын
Would you exchange your organs with any of these chips?
@bismarkosei4406
@bismarkosei4406 10 жыл бұрын
no I can't exchange my organs with such chip
@spodeian
@spodeian 10 жыл бұрын
Please don't let yourself get bought out and this end up discontinued
@digiarthur
@digiarthur 10 жыл бұрын
This chip would revolutionize human research as we can see the exact respond to human bodies rather than animal testing
@FUCKINMETALROCKS
@FUCKINMETALROCKS 10 жыл бұрын
This is the most badass shit ever, seriously. I just really hope this project keeps moving forward in a possitive direction, for good use only... *cough cough government cough*
@thomasgirolamo8952
@thomasgirolamo8952 Жыл бұрын
Where is this now?!?! By the way I have your niece Summer in my design and modeling class :)
@nastjastamenkovic1745
@nastjastamenkovic1745 2 жыл бұрын
incredible functionality??
@toralf.
@toralf. 10 жыл бұрын
The body parts on a chip is a brilliant idea, and be able to set it in a network to simulate the human body for research on diseases and other illnesses. Maybe the chip have to be more simulated as a real human, temperature and blood pressure etc.? To be able to treat different diseases we have to think of the external and internal factors of how the human body responds to diseases and non diseases. The human body is well built machine it can adapt and regulate itself for different situations of exposure to the human body. (hot, cold and diseases etc. and other factors.) Remember there are good and bad diseases (virus / bacteria) that can help the human body fight off other diseases etc. and the bad diseases is treated / fought off by the white blood cells and other treatments to cure the human body. There are treatments were the human is been put in stasis (controlled environment internal and external) to aid the human body to fight off diseases and better chance of recovery. By giving blood to others, does it mean the transferred blood's white blood cells aid the other person immune system? And is there a better way to aid the person immune system by human for human?
@xxhellspawnedxx
@xxhellspawnedxx 10 жыл бұрын
Yeah, as she presented it, there seems to be a few potentially important factors that this chip seems unable to take into consideration, like chemical and bio-electric signals that the cells pass between them. Temperature, however, can probably be simulated through a regulation of the blood and air partitions on the chip, just like it is in the real human body.
@KemaTheAtheist
@KemaTheAtheist 10 жыл бұрын
They're already working on it. It's called "human-on-a-chip."
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