Gleason 9 & 10 Prostate Cancer: Cure Rates, Treatments, New Approaches | Mark Scholz, MD

Gleason 9 & 10 Prostate Cancer: Cure Rates, Treatments, New Approaches | Mark Scholz, MD | PCRI

Рет қаралды 70,763

Жыл бұрын

Gleason 9 and 10 prostate cancers represent, potentially, the most dangerous of the newly diagnosed, non-metastatic, forms of prostate cancer because they have the highest likelihood of distant spread. However, a significant portion of these men will still be able to achieve a cure or durable remission with the proper treatment. Even more good news is that the recently FDA-approved PSMA PET scan offers men markedly improved staging compared to what was available before, which means a patient is more likely to receive appropriate treatment upfront. Here, PCRI's Alex asks Medical Oncologist Mark Scholz, MD, all about Gleason 9 and 10 prostate cancer in 2023.
0:06 In Gleason 9 prostate cancer, what is the significance of the volume of cancer graded as Gleason 5 and the amount graded as Gleason 4?
2:41 What are the cure rates in men with Gleason 9 prostate cancer?
3:17 Is focal therapy an option for Gleason 9?
4:39 Does radical treatment make more sense for a Gleason 9 to have the best chance of achieving a cure?
5:16 If someone with localized Gleason 9 is considering focal treatment, should they also have hormone therapy since it is a high-risk cancer?
7:00 Which forms of radiation are most effective for Gleason 9?
7:56 The two types of brachytherapy are "permanent" and "temporary" seed implants. Is one any better than the other?
8:23 How common is Gleason 10?
8:58 What is the "standard" protocol for Gleason 9 and 10 prostate cancer?
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The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians, for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better individualized care. Feel free to explore our website or call our free helpline at 1 (800) 641-7274 with any questions that you have. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
The information on the Prostate Cancer Research Institute's KZfaq channel is provided with the understanding that the Institute is not engaged in rendering medical advice or recommendation. The information provided in these videos should not replace consultations with qualified health care professionals to meet your individual medical needs.
#ProstateCancer #MarkScholzMD #PCRI

Пікірлер: 129

@tkbham5984 Жыл бұрын

Your videos are priceless. I'm 57 yrs old. In late 2021 PSA was 7.7. Biopsy revealed Gleason 3+4., Unilateral. I opted for robotic radical prostate removal in June 2022. Nerves were spared. 6 mos PSA non detectable. I was back to work one week after surgery. So far so good thanks to a team of prayer warriors covering me and your videos. My doctors are awesome but most of my knowledge I gleaned from you. As men, we can feel very alone in dire circumstances. Thank you for caring so much ❤️.

@duposflies2621 Жыл бұрын

Thesame here feel alone no one understand me, my so called friends told me aaahhh only prostate they can cure it nowadays. They don't know the feelings to be diagnos with cancer. Thanks God there is now internet to meet people who can understand you better.

@schmingusss 2 ай бұрын

That's awesome. Where did you get your surgery done?

@dcplunkett Жыл бұрын

"Please have those discussions with your doctors." I think this is the most important point. I would add that those discussions should be two-sided conversations, not one-sided lectures. And it's okay to say, "I don't understand" or "I don't know."

@richdannys2906 Жыл бұрын

Long time viewer. First-time commenter.. I love the PCRI videos!! Thank you for them! After experiencing pain in my lower back in late 2021, I got an MRI. My family doctor told me the problem wasn't with my back, but rather with my lymph nodes! He told me "I think you may have prostate cancer.." I went into a cold sweat! He did a quick DRE and had me do a PSA blood test, that same afternoon. The results were a PSA of 138! I really thought I was doomed and had only a short time left.. I had a biopsy later with a gleason score of 9 (5 + 4). Again, I thought that was another nail in my coffin.. Met with my medical oncologist who notified me that I was Stage 4 Metastatic. And that the pain I was experiencing was due to bone metastases. He suggested an aggressive triplet therapy: 6 rounds of chemo, plus HRT, and ADT (daily Abiraterone). The chemo wasn't as difficult as I'd expected it to be. My PSA fell quickly! I recently had my 2nd Bone Scan.. Though the spots of metastases are still mostly present.. There hasn't been any progression of the cancer. And I'm feeling a lot better about my future! My last blood test showed a new record low PSA of 0.48 When I had the Bone Scan, I asked the nurse about PSMA Pet Scanners.. As it turns out, here in Ontario Canada, hospitals are slowly beginning to take shipment of them. All of which will be incorporated into our free Health Care system. The hospital I go to, was supposed to receive theirs, last December. But there have been delays.. I look forward to seeing how these new machines will affect my future treatment!

@Mary-bx8gd Жыл бұрын

Your story is almost identical to my husbands! His PSA has been undetectable since after the chemo treatments. He also had the triplet Treatment which I believe was the best decision made! He will have the new PSA a pet scan this August. Best wishes to you, your doing great!

@richdannys2906 Жыл бұрын

@@Mary-bx8gd Thanks!! Great to hear your husband is doing well, too!

@the_weid9325 Жыл бұрын

Your story is almost the same as mine. Was diagnosed in Jan 2018 at 51 years old. My highest PSA was 42, and was Gleason 9. Cancer had spread to L5 vertabrae and hips, and a few lymph nodes. After the triple therapy, I've been undetectable since Aug 2020. Still on Lupron and Abiraterone. Keep fighting!

@marcgreenberg1271 Жыл бұрын

I wish I found your channel earlier. I get my healthcare through the VA. In April of 2021 I had a PSA of 11.98 after years of PSA between 2-3. I am 75 years old. My urologist did a biopsy and out of 12 specimens 7 had cancer cells with a Gleason score of 8 and 9’s. Surgery was never an option. Bone scar showed negative cancer in bones. I had gold seeds implanted in August of 21. Had 39 radiation treatments and 18 months of hormone therapy. Relight now my PSA is undetectable. I have erectile dysfunction and urine leakage,but at least I’m alive. Also had top half of my left lung removed because of lung cancer in 2017. I was exposed to Agent Orange in 1968 in Vietnam.

@dr.maicha3903 Жыл бұрын

Hello thanks for sharing your story as it gives relieve for myself..as my father is diagnosed case of ca prostate with bone mets..(gleason score 3+4) .my father was diagnosed with ca prostate 8 months back.he is having treatment in India. His Psa was 143 now after giving 10th cycle of chemo his psa is 1.93 . And doctor has advised to continue chemo and hormone therapy ..dnt know for howlong..?so i am soo much tensed about it ..iis it necessary to continue the chemo or is there any other option for it..iplz give me suggesstion if anyone knows the treatment option for the ca prostate with bone mets 😑 Thank you 😑🙏

@DaWorstBroadcastingNetwork Жыл бұрын

I am 65 years old. I was diagnosed with stage 4 prostate cancer on Nov 8 2022 with metastasis to my pelvis lymph nodes, and bone. My Psa was 1,024 yes thats correct 1,024. They did a byopsy and I had a gleason score of 4+3=7. My Oncologist stated me on hormone therapy right away, gave me 2 shot in my abdomen area. 3 weeks ago I started taking 2 tablets of nubeqa in the morning and 2 in the evening. This week I started my first of 6 rounds of chemo. Im feeling pretty good. Sticking to a strick diet. My Psa last dropped to 26 still high but a stark difference from 1024. Thank you

@dcplunkett Жыл бұрын

I got excellent results from chemo. I hope you do, too.

@Mary-bx8gd Жыл бұрын

My husband also got Excellent results from chemo! Best wishes!

@manisthemeasure2205 Жыл бұрын

Could you elaborate on your diet, please

@DaWorstBroadcastingNetwork Жыл бұрын

@@manisthemeasure2205 no carbs, no sugar, no processed foods, no seed oils. I eat red meat once every 10 days(grass fed) organic chicken, salmon 3 times a week , sardines, pastererd raised eggs, fermented foods like Kimchi, sour kraut, lots of greens, spinach, swiss chard, rapini, broccoli, zucchini, cauliflower, broccoli micro greens ,grass fed butter, avacado, extra virgin olive oil, coconu oil, non pasteurized yougurt, 100% cocoa chocolate, vitimin D3 K2, C, garlic pills and tumeric. Black coffee and green tea. These are the basic foods I eat.

@tinamina2634 Жыл бұрын

Thank you for sharing and so glad you’re doing well 🙏❤️

@Mary-bx8gd Жыл бұрын

Thank you for always providing information that gives hope! ❤️

@barrie888 Жыл бұрын

absolutey top-notch content. Thankyou to both Alex and Dr Scholz.

@hokkitt Жыл бұрын

Hello from Sweden. I never miss an episode from Dr. Schulz. He saved my mental healt back in november

@daviddion3731 Жыл бұрын

Thank you again for another great video. I've been following you two for two years now and have learned SO much. I'm a 71 YO in otherwise good health, my Gleason is 3+4 and my Decipher is 0.22, T1c. My PSA jumps around from a low of 5.35 to a high of 7.47 and all numbers in between. My second MRI showed the same small amounts, localized, and no movement relative to the first MRI. I have two more PSA labs to take before June 23 and after speaking again with my Radiation Oncologist and the Doc that did my Euro-Lift, I fully anticipate being shifted to a semi annual or annual monitoring routine. I say this only to let others know that although my two Docs have been great, I probably would not have understood as much of what they were saying had I not watched so many (several dozen) of your videos and a number of them I've watched a second or third time. Armed with the information you two have provided, I'm much more confident in my decision making process regarding different treatment options, only because of how you make the subject matter so easy to comprehend. Thank you both very much, and keep the vids coming! Gratefully, Dave, St. Petersburg, FL

@kennelson3848 9 ай бұрын

Thank you, glad your here.

@Its_just_me_again 10 ай бұрын

your channel is a valuable resource - thank you

@daviddavies8726 Жыл бұрын

Thank You

@rob8489 Жыл бұрын

My father was PSA 224 and then climbed to 266 prior to the start of ADT treatment. Firmagon brought him down in just a month to a PSA of 3. He continued firmargon through 5 weeks of radiation and then had a PSA of 0.7 and now 0.17 . His gleason score 9. (5+4 I believe) and all 12 cores positive. Only did conventional bone and CT scan which showed no spread other than to a few illiac lymph nodes. He now switched from FIrmagon to eligard I believe and has to wait 6 months before new scans to see how it looks. His team does say that they are aiming for a cure but I am definitely worried since he only did old conventional scans. I really hope that he is around for a long time and not knowing is very scary. John from prostate cancer research institute spoke to me on the phone about my fathers case prior to his treatment and helped me understand terminology as well as different questions to ask my fathers team as well as what to expect going forward. I am very thankfiul for that

@SomenathRoyChoudhury Жыл бұрын

Very informative, thanks

@timoherron657 Жыл бұрын

Hello Alex and Dr. Scholz, thank you again for everything you do, you have helped so many. I have a question I think would be good for a video. I am a 67 year old male and I was diagnosed in March of 2022 with MRI biopsy that showed 11 of 12 cores positive mostly Gleason 6 and 7 but one Gleason 8 (4+4) and one Gleason 9 (4+5) both high percentage of core 80 percent. Had the whole body bone and pelvis scan which showed no metastasis but because of the information I learned here I kept pressing for a PSMA Pet Scan which one year ago wasn’t easy to get but my urologist thankfully agreed to ask Medicare and it was approved. The PSMA came back negative so no signs of spread on PSMA scan. My PSA never went above 10, I believe 9.5 was the highest it ever got so a slight positive I would think but I do have high volume and high Gleason score disease. June 1st of 2022 I started Orgorvyx and had definitive Proton therapy for nine weeks (including the Seminal Vesicle and lymph nodes) then started Abiraterone September 1 2022. So I think I am one of the earliest patients to get a PSMA Pet Scan now approaching one year of ADT with Orgorvyx in June and September 1st will be one year Abiraterone. I know Dr. Scholz has said the protocols have not been worked out yet for people with High Risk Disease and a clear PSMA Pet Scan. I can’t get my oncologist to really entertain the possibility of stopping the ADT early but my radiation doctor did say he thinks 1 to 2 years of ADT is sufficient, my oncologist thinks 2 years. I consider myself lucky to be getting good care and some of the latest treatments available. I promised myself I would give everything I got to cure the cancer but would not risk ruining my health with the ADT treatments. I am definitely following Dr Scholz advise about exercise, exercise, exercise and don’t want to damage my body more than necessary for a cure. So my PSA has been undetectable and I also have Natera ( Signatera) Genetic Residual disease testing done every 3 months which also comes back negative for any signs of disease. I feel that I am reaching the point where the cumulative effects of the ADT are becoming a big risk to my long term health and I am considering stopping the ADT at the end of August which will give me 15 months on Orgorvyx and 12 months on Abiraterone. Alex could you please present my case to Dr. Scholz for a review as I am struggling with my decision to stop and need all the information I can get to make my choice. Thank you so much for your consideration.

@mikerose6835 Жыл бұрын

Thanks for another video clip very relevant for me Gleason 9 and on androgen deprivation therapy and radiation but currently PSA

@77Cfriend 6 ай бұрын

what type of radiation please? and how long ADT?

@francisexperience 5 ай бұрын

Great Information Thank You!!

@tboyleninetynine Жыл бұрын

I am a Gleason 9 patient, had a radical prostatectomy in February of 2022, and I consciously chose the aftermath of incontinence compared to the aftermath of radiation/hormone therapy. I am 74, and have been married for almost 52 years, and I felt the data supported my decision. My doc was excellent, but my surgery was quite complicated because I had had a TURP in 2010, and the tumor in the prostate (the 5 part of the Gleason number) had invaded both the urethra and the bladder. There was a lot of repair work that needed to be done and a normally 3 hour surgery took more than 6. I am just over 14 months out from surgery, and feel very positive that I made the right decision. All lymph nodes and all surrounding tissues were negative for spread, and I have had 2 PSA exams at 6 months and 1 year that were both at less than .02, i.e. undetectable. Thank you for this video, excellent as always!

@vk-bb 10 ай бұрын

I'm also gleason 9 and my PSMA pet scan shows possible metastasis in lymph nodes. How is this possible to have cancer in bladder and urethra without being in lymph nodes in your case?

@tboyleninetynine 10 ай бұрын

@@vk-bb The tumor itself in the prostate actually surrounded the urethra and was bulging out the side ('extra-prostatic extension' the Pathologist said). It had also invaded the neck of the bladder, which my surgeon removed, and then he had to do a lot of repair work. Just had my 3rd PSA check and I am still less than .02. My surgeon was very surprised that the lymph nodes and margins were clear. He told me that 98% of the time, my type of cancer had always 'left the premises' by the time the surgery was performed. It seems the tumor had a very thick/hard exterior membrane that had not yet been compromised. I fully expect to have biological recurrence within 5 years, but the new Luticium 77 treatment will be handy to fall back on as it is the perfect tool to deal with that. I do PSA checks every 6 months, and am due for another in November.

@77Cfriend 6 ай бұрын

did you avoid hormone treatment? and how is the incontinence? will it improve?

@tboyleninetynine 6 ай бұрын

I did avoid it. With respect to the incontinence, I started out using about 15 pads a day, with two or three changes of clothes as well. With pelvic floor therapy for 9 months, I worked it down to about 5 pads a day and able to wear the same clothes all day. Two months ago I had a procedure to install a sling around my urethra, and the incontinence all but disappeared. I need one pad a day, and another one at night, but the 'drips' have been virtually eliminated. My Urologist/surgeon this time was different because my original surgeon had moved to NYU to teach and practice. I am very pleased with the outcome at this point. Now almost 2 years out and PSA is still at the undetectable levels (most recent test last month).

@mangogrower5426 Жыл бұрын

Thank you Alex!

@CrazyHeat59 2 ай бұрын

love the content, first time commenting, I'm a two time cancer survivor, first was head and neck squamous cell, the second was stage 4 Non Hodgkin's Lymphoma, now I was diagnosed with prostate cancer with a Gleason score of 9 ( 5+4) with a grade of 5. Still waiting on a PSMA Pet scan, Mri showed lesion in hip same with bone scan. The Doctors who read the scan disagree on the spot. One feels its sinister the other can't say for sure. I'm really torn on treatment options for sure!

@pisheth 5 ай бұрын

Nice Video….Very informative….

@tedrick4713 11 ай бұрын

Thanks, good stuff.

@duposflies2621 Жыл бұрын

Hello, thank you for your videos its helps us a lot who have this shit in our system, I just diagnos of prostate cancer with gleason 9 and my psa was only 3.8, my bone scan is clear no cancer outside my prostate that keeps me positive. My urologist told me i have two options of threatment eather radiation or sugical operation, I hope to meet my oncologist soon. Here in Sweden it takes time to wait but my Doc. Told me to rush them at the Hospital for my threatment. Thank you again it help us to understand better.

@roger9463 Жыл бұрын

Gleeson 9 here diagnosed 9 months ago. PSA 9 down to undetectable before radiation. Pet scan negative for spread. My urologist said he was very surprised at how slow USA had been to start using pet scans compared to Australia. I’m currently on a trial with nubeqa H

@timoherron657 Жыл бұрын

Can I ask you how long you were put on ADT with a negative PSMA Pet Scan. I have the same Gleason 9 with clear PSMA Scan and my doctor wants 18 to 24 months of Lupron plus Zitiga.

@billwestervelt2393 10 ай бұрын

Same situation as you. G9 with no spread. My doctor (at a US center of excellence) says I can stop after 12 months if I want to. I think he has been watching Dr. Sholz videos. :) @@timoherron657

@roger9463 3 ай бұрын

Im on firmagon for 2 years which is part of the nubeqa trial. I’m on firmagon because it supposedly has less effect on the heart as I have had a coronary bypass. Australia health care is so good and sort of free!

@alexfrazer9480 Жыл бұрын

Thanks for your great videos. I was diagnosed with Gleeson 9 in Feb 2022. After my prostate was removed in April, l was told l had ductal prostate cancer, which affects roughly 100 Australian men per year. My PSA went from 7.4 to 0.045, 2 weeks after surgery. After 3 months, 0.050, after 6 months it was 0.056 - at 9 months it was 0.112. I had a PSMA PET scan and imaging MRI 6 months after surgery, which showed no visible signs of cancer. However, my doctor believes there is a chance my 12 month PSA reading could be at/around 0.250, which is a concern. Watching your videos has alerted me to diligently research treatment options, and to query my doctors regarding those options.

@77Cfriend 6 ай бұрын

did you do any hormone treatment?

@alexfrazer9480 6 ай бұрын

@@77Cfriend Not initially, but After 12 months they found cancer in my bladder. That’s when they did radiotherapy and Fermagon injections every 4 weeks. My PSA is now less than 0.01. My testosterone was measured as 0.1, but Side effects include 7kg weight gain, muscle loss, lack of energy, hot flushes and fatigue. My HIIT and resistance weight sessions are really tough to complete, but l force train myself.

@markmarshall357 Жыл бұрын

Thanks for the wealth of information. I frequently hear you speak about how PMSA PET is a game changer. I work and am a patient at one of the most respected hospitals in the world and inquired about PMSA PET post radiation and was told that this point it is bssically useless because there is no consensus on what results mean and how to interpret them. I am a gleason 9 (4+5) with extra capsular extension and paraneural involvement, was treated with radiation and am currently finishing my last lupron treatment.(24 months) Any opinion on whether I should pursue PMSA PET?

@af-xk3xq Жыл бұрын

A general pathologist examines the biopsy sample to determine Gleason score. Then another prostate specialized pathologist would independently do the examination to re- determine the score anew. The two scores should hopefully the same. Keep in mind an accurate (though subjected to be qualitative if not subjective judgement) score/stage is pivotal in determining the most effective treatment regime. Is this standard universal? If the samples were from random sampling but not from targeted sampling when the location and size of the leisons were already known, the Gleason score and stage could be misleading.

@eb4452 Жыл бұрын

What is the correlation between Gleason grade and PSMA expression? Is it more or less likely to be expressed in GG4 and GG5 than in other cancers?

@frederickrich7393 Жыл бұрын

Hi there Alex, I was diagnosed with gleeson 8 4 + 4, with 7 psa. I am now 71years,I was put on hormone injections for 2 years then had 20 radiotherapy treatments, I was able to stop the hormones 6 months early as my PSA had dropped to 0.01, I am now being tested every 6 months for testosterone and Psa, it would have been good if they had tested my testosterone before all the treatments as I don't have a clue what the level was before hormones.

@somehingbouthiseyes Жыл бұрын

did injections and radiotherapy alone without prostate removal cure the cancer? and how was the side effects with those 2 treatments?

@frederickrich7393 Жыл бұрын

Hi there, in my case they said prostate removal was not the best option because they might not get all of the cancer out. I had 3 monthly hormone injections for 18 months instead of 2vyears because my psa levels had dropped to 0.01 after I had 20 radiotherapy sessions, side effects to the hormones were mild and radiotherapy was no problem at all. Hope that helps.

@user-rk7qk2lz3m 7 ай бұрын

So thankful for this channel! 76yo with gleason 4+5=9 PSA was 11.5 ten weeks ago. Started Lupron and ADT 9 weeks ago. After 6 weeks PSA was .24, After 8 weeks it is now .09. I was told at the beginning that radiation (scheduled late January 2024) was by only option. My question is, with the PSA dropping so fast, might I now have other options?

@af-xk3xq Жыл бұрын

Brachytherapy can be by injection of radiation on carrier gel through the perineum targeting the leisons for some 20 minutes resident time before pumped out if the prostate. The procedure other than direct irradiation on the leisons, it can elicit subsequently highhten immune response against the cancer. Any elaboration on this procedure other than by seed implant

@rolfemch7718 2 ай бұрын

Hello from Switzerland. Thank you very much Dr. Scholz and Alex, for the education on prostate cancer to everyone via KZfaq videos. My situation is the following: Prostate cancer diagnosed in May 2014, PSA = 32, Gleason Score = 9 (4+5), initial pT2c pN1 cM0. My age at that time: 75. Prostate too large (200g) for an immediate OP. Eligard. June 2015 radical prostate removal. After OP PSA = 0, no Eligard any more. 2018: PSA = 2.5. PSMA-PET: 5 small lymphnode metastasis (4-5 mm) detected on different locations and a larger one (11 mm). This one totaly eliminated by radiation therapy. Elimination of ths metastasis had no effect on PSA. New start with Eligard, PSA in September 2019 = 0. From March 2021 on PSA smoothly climbed to 1.5 in September 2023. At this time i had to change my oncologist (Long Covid). New therapy since September 2023: Zoladex and Xtandi. PSA today 0.02. I am 85 now, do not suffer any severe side effects on those medications, exept loss of muscle mass and weight (7 kg since September 2023) and this despite the fact that I train for an hour every day. My wife and I enjoy every day in our home, travelling and on vacation. I would like to hear from you, if the actual therapy ist the best for me, or if you have any suggestions for improvement which I could discuss with my oncologist. Thank you in advance for any advice. Rolf

@ThePCRI Ай бұрын

Hello Rolf, we are not able to answer case questions on our comment section but we can help you through our Helpline who can speak with you either by phone or email. Here is the link to contact them: pcri.org/helpline

@Mari-su3nv Жыл бұрын

Not sure if there's a video on it , but would like to know more about Cryo salvage . After Cyberknife radiation my 3+3 (or 3+4?) Gleason , PSA of 16 , T1c dropped to the 4's for a few years , then nadired at 1.25 , and after that rose for 2 years to 3.5 . At that point I had Salvage Cryo and it dropped to < .01 for 4 years now . Cured or can still return? Never had any Hormone teatment Highly rec. Dr. Aaron Katz for Cryo at Langone , a Master Cryo pioneer . PS - Salvage Cryo likely to cause impotence and some degree of incontinence but the trade off for (so far) 4 years of .01 a no brainier .

@garyclarke8862 Жыл бұрын

Please explain in detail what focal therapy is

@Mari-su3nv Жыл бұрын

Focal was mentioned . I was just wondering that should one choose Focal and later develop additional tumors if a second round of radiation was possible.

@garyclarke8862 Жыл бұрын

I have never been given a satisfactory answer to my question and hope you can answer me. I have had 2 TURPS .I want to know what diagnosis processes are for levels of prostate cancer there before the decision is made to operate and remove the prostate by robotic operation. I was never told about Gleason score. I was just booked in and had robotic surgery to remove my prostate only to find the Olympic nodes were also removed and I only had 25% cancer in the left node. I do believe that that could have been cured and that I did not have to have a R66 000.00 operation.

@tomswoverland Жыл бұрын

Are you talking cured or remission. I’ve been dealing with Gleason 8 for more than 3 years I had a 6 month remission before it came back. I don’t believe in cured only remission. Thanks for the video’s.

@j.jsjourneysouthafrica3806 11 ай бұрын

Hi there they said my husband is a Gleason 9 low risk with one bone met left hip and lymph nodes... Plz advise what does that mean exactly please based in south Africa Cape town

@thomasroberts5125 9 ай бұрын

I was diagnosed with a Gleason 9 Prostate Cancer in December 2022. The Prostate was surgically removed in early June 2023. My PSA is at .08, but have not been able to obtain a PSMA scan to determine if there has been spread. Does the 0.8 PSA dictate additional treatment such as hormone and radiation or should there be a wait time to determine if the PSA remains stable?

@couturegalx3 Жыл бұрын

Did anyone catch what he said after what is the psa at 3:09? It sounded like he said if there are multiple chorals or chords present??

@ThePCRI Жыл бұрын

Hello, He said, "multiple cores present" which refers to biopsy cores.

@wmartens3806 Жыл бұрын

Why isn’t Transurethral hyperthermia therapy ever mentioned as an option for treatment? 1:47

@garyclarke8862 Жыл бұрын

Oh and please explain what is pet therapy/scan.

@vannburchfield7007 4 ай бұрын

Hello, I had my PSA double from 2.5 to 5.0 when I was 55 years old and paid for my own HIFU treatment. Now another 3+3 Gleason score tumor has formed and PSA has slowly risen to 4.8. My question is this… What is the amount of decreased PSA number from drawing the blood at 9:00am versus 4:00pm We all know testosterone levels are higher in the morning but what is the difference for the PSA. 3.8 in the morning to possible 4.8 in the afternoon? Any studies or data? Thanks!!! I always enjoy listening. I am 62 years old now.

@billwestervelt2393 Жыл бұрын

60 YO, localized G9 and just concluded 44 sessions of whole prostate RT including lymph nodes. Negative PSMA PET. 6 Months into ADT and the question will be do I do 12 months, 18 Months, or 24? This video was very helpful.

@carlchappell6383 Жыл бұрын

Very similar diagnosis, 60 yrs old gleason 9, lymph nodes and seminal vesicle involvement 38 r/t just finished 9 months into adt and just over two years to go I'm trying to keep the mindset right exercise daily healthy eating very supportive family around me, gob bless all going through PC stay in the game

@johnolenczak1552 Жыл бұрын

Can you speak about apalutamide

@joelang9796 Жыл бұрын

What would yo suggest for someone with Gleason 10 group 5

@ellenfalveycarroll4489 Жыл бұрын

Seems i lost contact via utube dont know why im back 🇨🇮🙏❤️🌷👏

@77Cfriend 6 ай бұрын

looks like lots of people ask questions that never get answered

@sayedgoda2099 Жыл бұрын

Hi. Thank you for your excellent program. Can you help with this, please? I have a prostate cancer G9 metastatic in the pelvic with 3 lesions. I had radiation between March- May 2019 and started taking abiraterone from January 2019 till present. My PSA is less than 0.01 for more than four years and still. The question is, is it safe to stop abiraterone? Will my cancer come back? What is the advice please

@cjh6169 Жыл бұрын

I love your videos. They have been quite educational for me, the wife of someone who is Gleason 9. Question: in a situation where it’s been confirmed at least one bone met with Gleason 9, should you have the primary area (prostate) treated with radiation or just the met? What are the options in this case? There is pain involved, also.

@mohankumargajendran528 Жыл бұрын

My dad is 84 years old, 4/5. no signs in PET. perineural spread trace alone present. currently only on Degralix (since 8 months). we are worried radiation might affect his bladder. and chemo could affect his kidney. he has 2x45%kidney. (PSA

@blackbiker1961 Жыл бұрын

Wow am I hearing this right there are cure rates for stage 4 prostate cancers?

@josephsweeney4245 Жыл бұрын

Will a psma pet scan pick up any cancer cells or only those over a certain size.....I have been on decapeptyl hormone therapy for about 2 years/gleason score 9 but psa tests presently almost undetectable. Hormone treatment, as I understand, does not destroy cancer cells, it only shrinks it by starving the cancer of testosterone. There is no way of knowing if all cancer cells are gone??? Or does a psma pet scan give a definitive answer?? Ps also long time viewer ... Great informative videos. Cheers

@jimmysmith377 Жыл бұрын

what happens if you dont want treatment. my psa 41 and cancer in lypm noades . no one talks about this .thankyou jimmy

@vimzibaiegh Жыл бұрын

Hi Jimmy, The decision is yours. I've heard Dr Scholz say that in a few videos. I had PSA 13 in January 2023 which dropped to 7 three months later. I also had a clean MRI i.e. no lesions or any other detectable signs of cancer. Regardless of the MRI, two US DR's recommend biopsy. Other than biopsy I've been offered no additional advice or treatments (other than repeated PSA's). So since I"m not going to have 12 needles stuck into my prostate, I'm basically done. You could probably get chemo for the lymph nodes, but I'll be waiting until I'm sick. As long as I'm feeling OK I'm not doing anything. If one morning I wake and can't urinate, I'll go to the emergency room and let them do whatever it takes. But until that day, no one is touching my prostate and I'm not taking chemo.

@carlosdanger1014 Жыл бұрын

I am Bi-polar. Psyc SAS NO WAY to ADT....I am G9 and have done 38 treatments of radiation at Mayo. PsmaPet showed N1 and no MO anywhere else. He radiated ALL pelvic nodes. Please address. Thank you. We BiPolar men have an issue for sure.

@princesethi7655 Жыл бұрын

My dad is suffering from prostate cancer with bone metasis and has Gleason score 5+4. Currently he is on chemo therapy and PSA level increasing and did fall after 14 cycle. Can you please let me know what to do in these case ? Any idea when PSA will decrease

@ThePCRI Жыл бұрын

Hello, we have a helpline with patient advocates that can provide you with information that may help your father’s case. You can find our contact information at pcri.org/helpline.

@keithcolegrove2924 2 ай бұрын

Howdy everyone. 70 years old. Last PSA was 9.2. PHI was 60, bad. MRI was Pirads 5, bad, Transparinal targeted biopsy was 4+5=9, bad. PSMA Pet scan shows no spread outside the prostate, good. MRI shows 17 mm lesion on left side only located in 3 zones. 2 zones on left side benign. Entire right side of prostate benign per MRI, and PSMA Pet scan and biopsy. Getting PSA test in a couple days before meeting cancer DR. later this week. Need feedback on whether to get a short course of ADT along with radiation. I know the verdict is not yet out on that decision. What about chemo with radiation on such a high Gleason, but a negative PSMA Pet scan. All comments are welcome and appreciated.

@PanioloBee 8 ай бұрын

How can one raise their energy level without raising their testosterone level? I finished with my proton treatment and am now taking Lupron injections every three months.

@DCGreenZone 5 ай бұрын

Keep an eye on this, seems important. >>Undetectable levels of Prostate Specific Antigen (PSA) have been reported from the first patient with metastatic castrate-resistant prostate cancer (mCRPC) to ever receive two cycles of Clarity’s 67Cu-SAR-bisPSMA at the 8GBq dose level. PSA is a marker of tumour burden, clinical response to treatment and an indicator of the recurrence of disease for prostate cancer.

@roger9463 Жыл бұрын

Continuing…on a nubeqa trial to see if it will stop cancer spread from the prostate. Of course I dont know if I’m getting the placebo! Also on ADT ( firmagon ) for 2 years …..😊

@elitetrader5468 Жыл бұрын

How do you feel?

@roger9463 Жыл бұрын

@@elitetrader5468 : I feel fine , if a little tired at times due to low testosterone I suspect. Had the usual radiation after effects , but they have largely worn off.

@elitetrader5468 Жыл бұрын

@@roger9463 I am glad to hear this! Keep fighting!

@curtisdishong3540 10 ай бұрын

If it’s the estrogen reacting with testosterone then why do we take hormones for testosterone but not estrogen?

@shituyau6580 Жыл бұрын

Having a godfather like Doctor osaye was a blessing,right from my childhood,he had shown me the importance and the necessity in human lives,thanks for your glorious impact to my health life©®

@markholbrook9639 Жыл бұрын

What do i do, I cant afford hormone pills they cost 891.00 a month. so i have stop all my appointments with the cancer center.

@patriciageorge9648 9 ай бұрын

If you’re talking about Zytiga Mark Cuban online pharmacy has the generic for about $100/month.

@richelledejong4863 Жыл бұрын

We just got my dads Gleason score 10, (all biopsy’s were 5 + 5) Stage 4 with metastasis to the spine and pelvic with a PSA 58 with normal testosterone. He is 79 years old and had his last PSA at 76 years old which was normal. This has been a fast spreading. Does anyone have experience with this and what treatments did they use! Please optional treatments for this . Are family is deviated.

@hotwalkinjohn Жыл бұрын

I have 5 +5 diagnosed in 6/2022. Psa of 31. Spread to all the areas like your father. I was started on lupron injection then 6 3 week infusions with taxotere. Nubeqa was added in October. I now have 0 psa and no detectable cancer. I was originally given a few months to live. Oh I am 71 with no prior health issues. I went to Hopkins, Mass General and MDA looking for answers. I have no idea how long I have to live with estimates from one to 10 years. It is a devastating diagnoses but reassure your Dad he can survive this. Exercise as much as possible and practice gratitude. One day at a time with no forecasting the future.

@kellygargan6895 Жыл бұрын

My father is 9s and 10s. He was genetic tested and found to have the brca2 mutation. He has also metastasized to the spine, bone and lymph. He is 72 years old. His PSA was normal in 2021 and at time of diagnosis, june 2022 was 16. He is currently only on ADT. No radiation or chemo at this point. Was he genetic tested? I was tested after my father and also have the mutation. I found out less than 2 months later that I now have breast cancer. So I urge him to be tested. Luckily my cancer was caught very early.

@richelledejong4863 Жыл бұрын

@@hotwalkinjohn thank you John for your reply. I am so sorry for your diagnosis and I happy to hear things seem to going in the right direction. May I ask if they suggested to remove your prostate or suggested CAR T-cell? My father has his second appointment at City of Hope in Duarte on Wednesday so we don’t know what to expect with the now known Gleason score. He always has had PSA tests up until 3 years ago and it’s been normal so it’s super aggressive. How is your bone pain if any? Also are you open to sharing your experience with my dad? I know it helps him talking to others that have shared his experience. We just found out he had cancer around Christmas and every test the news just gets worse, so we are trying to educate ourselves as much as we can.

@richelledejong4863 Жыл бұрын

@@kellygargan6895 hi Kelly, yes he was genetically tested, we are waiting for the results as we go back to City of Hope on Wednesday. I’m so glad you found your cancer early, that is the key to most cancers. It sounds like they might have that same rare prostate cancer as my dads PSA was normal 3 years ago. (The stop giving PSA tests at 76 years old) What about bone pain? I appreciate any information you can provide as we are trying to understand everything we can about his diagnosis to best help him survive and best this as long as we can. Also is your father open to talking to my father about his experience so far?

@kellygargan6895 Жыл бұрын

At this time the only bone pain he has is in his butt/pelvic region. The doctors feel it isn't cancer pain and more of a sciatic issue. His PSA went from 1.45 to 16 in just one year.