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SUMMARY: This video provides learners at the high school and AP Biology level with an overview of glycolysis. You might also enjoy my other glycolysis rap: • Glycolysis! (Mr. W's M...
LYRICS
Woke up this morning, sugar was on my mind (her name is glucose)
Woke up this morning, sugar was on my mind
It's time for my sugar's breakdown,
It's glycolysis time.
My sugar is so sweet,
She means so much to me,
But I'm prepared to give her up,
For a little ATP
Her chemical formula
C6H12O6
Glycolysis will break her down,
With enzymatic tricks
Ten separate reactions,
Ten separate enzymes,
In a cytoplasmic assembly line,
Cells do it all the time!
CHORUS
Glycolysis
Has 3 basic parts.
The 1st part's activation,
So that's where we'll start
Enzymes take two phosphates from ATP,
And jam them onto glucose,
With through some rearrangements
Is now really a fructose
Fructose 1-6 diphosphate
Brimming with energy
About to fall apart
In the next step you will see,
CHORUS
Glycolysis's name
Comes from its second part
When fructose 1-6 diphosphate
By enzymes is ripped apart.
Cause glycolysis means splitting sugar,
And this is really cool,
This cleavage results in two
three-carbon molecules
And when the next enzyme does its work
We'll see that my sugar's fate
Was to be made into two
Glyceraldehydes 3 phosphates
CHORUS
Glyceraldehyde 3 phosphate
Is known as G3P
And in step 3 of glycolysis
We harvest its energy
The harvest begins
With NAD+'s reduction
To NADH, which has
Electron carrying function.
Then enzymatic action,
Harvests more energy,
Which comes as the payoff
2 ATPs from each G3P
CHORUS
1 NADH, 2 ATPs
From every G3P
So the gross yield per glucose is 2 NADH
and 4 ATPs
But remember the 2ATPs
Invested in step 1
So the net yield is 2 ATPs
You can use to jump or run
So our overall net is
2 NADH and 2 ATPs
My sugar it was worth it,
Forgive me baby please.
CHORUS
When all was done, I looked at my sugar,
She didn't look that great,
Two ATPs, two NADHs,
two three-carbon pyruvates
NADH is used in the last part
Of cellular respiration
It's fuel to make ATP in
Oxidative phosphorylation
So when you look at your sugar.
Have some pity in your eyes
Glycolysis, getting energy,
Is based on your sugar's demise!