Amanda Holden's Nan, Myrtle, is left in charge of looking after Amanda’s daughters while she is on a holiday with her husband, Chris. While Amanda is away, Myrtle and her best friend Pat get drunk and trash the house. Amanda finds video evidence of her grandmother doing shots and breaking her favorite plant.
Later, Amanda plans a birthday party for Myrtle and invites all her friends as well as some famous faces! Tamzin Outhwaite (Eastenders) livens up the party as she gets everyone, including Ruth and Eamonn from Good morning Britain, Ashley Roberts (The Pussycat Dolls) and Craig Revel Horwood (Strictly Come Dancing), to play some party games.
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